Patents by Inventor Mladen Barbic
Mladen Barbic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11627937Abstract: A gripping apparatus includes: a temperature adjusting device held in a substrate wherein the substrate defines an open region; a phase change material held within the open region and thermally coupled with the temperature adjusting device such that a temperature change in the temperature adjusting device causes a temperature change in the phase change material; and a controller connected to the temperature adjusting device and configured to send a signal to the temperature adjusting device to change its temperature and thereby change the temperature of the phase change material that is thermally coupled with the temperature adjusting device. The phase change material is either in a solid state and configured to grip a stick or in a liquid state and the phase change material and configured to loosen its grip on the stick such that the stick is capable of moving through the phase change material.Type: GrantFiled: August 25, 2022Date of Patent: April 18, 2023Assignee: Howard Hughes Medical InstituteInventors: Mladen Barbic, Richard Smith
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Publication number: 20220401065Abstract: A gripping apparatus includes: a temperature adjusting device held in a substrate wherein the substrate defines an open region; a phase change material held within the open region and thermally coupled with the temperature adjusting device such that a temperature change in the temperature adjusting device causes a temperature change in the phase change material; and a controller connected to the temperature adjusting device and configured to send a signal to the temperature adjusting device to change its temperature and thereby change the temperature of the phase change material that is thermally coupled with the temperature adjusting device. The phase change material is either in a solid state and configured to grip a stick or in a liquid state and the phase change material and configured to loosen its grip on the stick such that the stick is capable of moving through the phase change material.Type: ApplicationFiled: August 25, 2022Publication date: December 22, 2022Inventors: Mladen Barbic, Richard Smith
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Patent number: 11471125Abstract: A gripping apparatus includes: a temperature adjusting device held in a substrate wherein the substrate defines an open region; a phase change material held within the open region and thermally coupled with the temperature adjusting device such that a temperature change in the temperature adjusting device causes a temperature change in the phase change material; and a controller connected to the temperature adjusting device and configured to send a signal to the temperature adjusting device to change its temperature and thereby change the temperature of the phase change material that is thermally coupled with the temperature adjusting device. The phase change material is either in a solid state and configured to grip a stick or in a liquid state and the phase change material and configured to loosen its grip on the stick such that the stick is capable of moving through the phase change material.Type: GrantFiled: August 12, 2019Date of Patent: October 18, 2022Assignee: Howard Hughes Medical InstituteInventors: Mladen Barbic, Richard Smith
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Publication number: 20210088606Abstract: An apparatus includes a magnetic apparatus that defines an actuation volume that is large enough to accommodate a sample, the magnetic apparatus including a magnet that is configured to create a magnetic field having a magnitude B in the sample when supplied with a DC current; at least one biological construct within the sample, the biological construct configured to change its status in response to a change in a property; and at least one magnetocaloric actuator coupled with the biological construct. A change in a characteristic in the actuation volume causes the property of the magnetocaloric actuator to change, which causes a change in the status of the biological construct.Type: ApplicationFiled: December 3, 2020Publication date: March 25, 2021Inventor: Mladen Barbic
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Patent number: 10908237Abstract: An apparatus includes a magnetic apparatus that defines an actuation volume that is large enough to accommodate a sample, the magnetic apparatus including a magnet that is configured to create a magnetic field having a magnitude B in the sample when supplied with a DC current; at least one biological construct within the sample, the biological construct configured to change its status in response to a change in a property; and at least one magnetocaloric actuator coupled with the biological construct. A change in a characteristic in the actuation volume causes the property of the magnetocaloric actuator to change, which causes a change in the status of the biological construct.Type: GrantFiled: April 4, 2018Date of Patent: February 2, 2021Assignee: Howard Hughes Medical InstituteInventor: Mladen Barbic
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Publication number: 20200046317Abstract: A gripping apparatus includes: a temperature adjusting device held in a substrate wherein the substrate defines an open region; a phase change material held within the open region and thermally coupled with the temperature adjusting device such that a temperature change in the temperature adjusting device causes a temperature change in the phase change material; and a controller connected to the temperature adjusting device and configured to send a signal to the temperature adjusting device to change its temperature and thereby change the temperature of the phase change material that is thermally coupled with the temperature adjusting device. The phase change material is either in a solid state and configured to grip a stick or in a liquid state and the phase change material and configured to loosen its grip on the stick such that the stick is capable of moving through the phase change material.Type: ApplicationFiled: August 12, 2019Publication date: February 13, 2020Inventors: Mladen Barbic, Richard Smith
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Publication number: 20180292479Abstract: An apparatus includes a magnetic apparatus that defines an actuation volume that is large enough to accommodate a sample, the magnetic apparatus including a magnet that is configured to create a magnetic field having a magnitude B in the sample when supplied with a DC current; at least one biological construct within the sample, the biological construct configured to change its status in response to a change in a property; and at least one magnetocaloric actuator coupled with the biological construct. A change in a characteristic in the actuation volume causes the property of the magnetocaloric actuator to change, which causes a change in the status of the biological construct.Type: ApplicationFiled: April 4, 2018Publication date: October 11, 2018Inventor: Mladen Barbic
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Publication number: 20180292478Abstract: An imaging apparatus for imaging a sample includes a magnetic apparatus that defines a sample volume that is large enough to accommodate the sample to be imaged, and one or more magnetically manipulatable materials within the sample. The magnetic apparatus includes a magnet that is configured to create a magnetic field having a magnitude B in the sample Each magnetically manipulatable material is a material that exhibits a transition between a first magnetic state and a second magnetic state in response to a change in a property associated with the sample while the magnetic field having the magnitude B is maintained in the sample.Type: ApplicationFiled: April 4, 2018Publication date: October 11, 2018Inventors: Mladen Barbic, Stephen Dodd, Herman Douglas Morris, Alan Koretsky
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Patent number: 9880149Abstract: A glass pipette such as an electrode for electrophysiological recording is coated with quantum dots. This greatly aids the ability to observe the glass pipette, particular in tissue as the quantum dots provide an excellent performance under two-photon illumination used to visualize objects at depths of hundreds of microns.Type: GrantFiled: February 5, 2014Date of Patent: January 30, 2018Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Igor L. Medintz, Bertalan K. Andrasfalvy, Kimihiro Susumu, James B. Delehanty, Alan L. Huston, John J. Macklin, Mladen Barbic
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Publication number: 20150147803Abstract: A glass pipette such as an electrode for electrophysiological recording is coated with quantum dots. This greatly aids the ability to observe the glass pipette, particular in tissue as the quantum dots provide an excellent performance under two-photon illumination used to visualize objects at depths of hundreds of microns.Type: ApplicationFiled: February 5, 2014Publication date: May 28, 2015Applicants: Institute of Experimental Medicine of the Hungarian Academy of Sciences, Howard Hughes Medical Institute, The Government of the United States of America, as represented by the Secretary of the NavyInventors: Igor L. Medintz, Bertalan K. Andrasfalvy, Kimihiro Susumu, James B. Delehanty, Alan L. Huston, John J. Macklin, Mladen Barbic
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Patent number: 8356763Abstract: Methods and arrangements to lyse a biological sample are described. The arrangements comprise a lysis tube containing the sample, one or more electromagnets generating a magnetic field, and one or more permanent magnets inside the lysis tube. The permanent magnets move and lyse the sample when a magnetic field is generated by the electromagnets.Type: GrantFiled: March 22, 2012Date of Patent: January 22, 2013Assignee: California Institute of TechnologyInventors: Aditya Rajagopal, Axel Scherer, Mladen Barbic
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Publication number: 20120175441Abstract: Methods and arrangements to lyse a biological sample are described. The arrangements comprise a lysis tube containing the sample, one or more electromagnets generating a magnetic field, and one or more permanent magnets inside the lysis tube. The permanent magnets move and lyse the sample when a magnetic field is generated by the electromagnets.Type: ApplicationFiled: March 22, 2012Publication date: July 12, 2012Inventors: Aditya RAJAGOPAL, Axel SCHERER, Mladen BARBIC
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Patent number: 8201765Abstract: Methods and arrangements to lyse a biological sample are described. The arrangements comprise a lysis tube containing the sample, one or more electromagnets generating a magnetic field, and one or more permanent magnets inside the lysis tube. The permanent magnets move and lyse the sample when a magnetic field is generated by the electromagnets.Type: GrantFiled: September 4, 2009Date of Patent: June 19, 2012Assignee: California Institute of TechnologyInventors: Aditya Rajagopal, Axel Scherer, Mladen Barbic
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Patent number: 8197234Abstract: An electromagnetic actuator for a microfluidic pump of the type that causes periodic pinching and releasing against the walls of a fluidic channel, e.g., a tube. At least one permanent magnet is placed against the walls of the fluidic channel, and located in an area with magnetic fields, produced by coils that are radially symmetric to the channel. The permanent magnet is cause to press and release against the wall of the fluid channel to cause a fluid flow through the channel.Type: GrantFiled: May 24, 2005Date of Patent: June 12, 2012Assignee: California Institute of TechnologyInventors: Morteza Gharib, Derek Rinderknecht, Mladen Barbic
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Patent number: 8170316Abstract: Tomographic imaging using an imaging sensor that has a stripe-like shape is disclosed where a stripe sensor is mechanically scanned over a sample at different angles. For a single stripe detector imaging, linear motion and angular rotation are required. Single stripe sensor imaging may be performed using an elongated inductive coil detector. By utilizing an array of parallel stripe sensors that can be individually addressed, two-dimensional imaging can be performed with rotation only, eliminating the requirement for linear motion, e.g. with parallel coils array. Imaging with a stripe-type sensor of particular width and thickness (where width is much larger than thickness) is resolution limited only by the thickness (smaller parameter) of the sensor. Multiple sensor families can be produced where this imaging technique may be beneficial such as magneto-resistive, inductive, SQUID, and Hall effect sensors, and particularly in the field of magnetic resonance imaging (MRI).Type: GrantFiled: October 1, 2008Date of Patent: May 1, 2012Assignee: California Institute of TechnologyInventors: Mladen Barbic, Axel Scherer
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Patent number: 7892427Abstract: Apparatus and method for manipulating particles on a micro- or nano-scale. An embodiment of the present invention includes a magnetic micro-manipulation technique that utilizes micro-coils and soft magnetic microscopic wires for localized manipulation of particles. Another embodiment of the present invention uses magneto-static interaction between two magnetic microscopic wires to mechanically manipulate particles. Yet another embodiment of the present invention combines a magnetic particle with a magnetic manipulator or other device for generating magnetic fields to operate as a micro-fluidic micro-motor. Other embodiments of the present invention employ a magnetic separation system employing porous membranes partially filled with magnetic wires.Type: GrantFiled: August 28, 2008Date of Patent: February 22, 2011Assignee: California Institute of TechnologyInventors: Mladen Barbic, Jack J. Mock, Andrew P. Gray
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Publication number: 20100068781Abstract: Methods and arrangements to lyse a biological sample are described. The arrangements comprise a lysis tube containing the sample, one or more electromagnets generating a magnetic field, and one or more permanent magnets inside the lysis tube. The permanent magnets move and lyse the sample when a magnetic field is generated by the electromagnets.Type: ApplicationFiled: September 4, 2009Publication date: March 18, 2010Inventors: Aditya Rajagopal, Axel Scherer, Mladen Barbic
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Publication number: 20090092509Abstract: Apparatus and method for manipulating particles on a micro- or nano-scale. An embodiment of the present invention includes a magnetic micro-manipulation technique that utilizes micro-coils and soft magnetic microscopic wires for localized manipulation of particles. Another embodiment of the present invention uses magneto-static interaction between two magnetic microscopic wires to mechanically manipulate particles. Yet another embodiment of the present invention combines a magnetic particle with a magnetic manipulator or other device for generating magnetic fields to operate as a micro-fluidic micro-motor. Other embodiments of the present invention employ a magnetic separation system employing porous membranes partially filled with magnetic wires.Type: ApplicationFiled: August 28, 2008Publication date: April 9, 2009Inventors: Mladen Barbic, Jack J. Mock, Andrew P. Gray
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Publication number: 20090087064Abstract: Tomographic imaging using an imaging sensor that has a stripe-like shape is disclosed where a stripe sensor is mechanically scanned over a sample at different angles. For a single stripe detector imaging, linear motion and angular rotation are required. Single stripe sensor imaging may be performed using an elongated inductive coil detector. By utilizing an array of parallel stripe sensors that can be individually addressed, two-dimensional imaging can be performed with rotation only, eliminating the requirement for linear motion, e.g. with parallel coils array. Imaging with a stripe-type sensor of particular width and thickness (where width is much larger than thickness) is resolution limited only by the thickness (smaller parameter) of the sensor. Multiple sensor families can be produced where this imaging technique may be beneficial such as magneto-resistive, inductive, SQUID, and Hall effect sensors, and particularly in the field of magnetic resonance imaging (MRI).Type: ApplicationFiled: October 1, 2008Publication date: April 2, 2009Applicant: California Institute of TechnologyInventors: Mladen Barbic, Axel Scherer
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Publication number: 20070238971Abstract: Systems and methods for obtaining two- and three-dimensional magnetic resonance images by using azimuthally symmetric dipolar magnetic fields from magnetic spheres. A complete two- or three-dimensional structured rendering of a sample can be obtained without the motion of the sample relative to the sphere. Magnetic spheres in the range of 100 ?m and 100 nm are used with samples that are approximately one-tenth as large as the magnetic sphere. Sequential positioning of the integrated sample-sphere system in an external magnetic field at various angular orientations provides all the required imaging slices for successful computerized tomographic image reconstruction. The requirement to scan the sample relative to the magnetic tip is eliminated. Resolutions approaching atomic dimensions are expected to be obtained.Type: ApplicationFiled: January 4, 2007Publication date: October 11, 2007Applicant: California Institute of TechnologyInventors: Mladen Barbic, Axel Scherer