Patents by Inventor Mladen Mercep

Mladen Mercep has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thienodibenzoazulene compounds as tumor necrosis factor inhibitors
    Publication number: 20050171091
    Abstract: The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-?) and interleukine 1 (IL-1) in mammals at all diseases and conditions where these mediators are excessively secreted. The compounds of the present invention also demonstrate an analgetic action and can be used to relieve pain.
    Type: Application
    Filed: March 25, 2005
    Publication date: August 4, 2005
    Applicant: Pliva d.d.
    Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic, Zeljko Zupanovic, Boska Hrvacic
  • 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
    Publication number: 20050148578
    Abstract: The present invention relates to 1-aza-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-? (TNF-?) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
    Type: Application
    Filed: November 22, 2004
    Publication date: July 7, 2005
    Applicant: Pliva-Istrazivacki Institut d.o.o.
    Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic
  • 1-oxa-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
    Publication number: 20050148577
    Abstract: The present invention relates to 1-oxa-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-? (TNF-?) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
    Type: Application
    Filed: November 22, 2004
    Publication date: July 7, 2005
    Applicant: Pliva-Istrazivacki Institut d.o.o.
    Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic
  • 1-Oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof
    Publication number: 20050148576
    Abstract: The present invention relates to derivatives of 1-oxa-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumour necrosis factor-? (TNF-?) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
    Type: Application
    Filed: April 9, 2003
    Publication date: July 7, 2005
    Applicant: Pliva-Istrazivacki Institut d.o.o.
    Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic, Iva Benko
  • 1-or 3-thia-benznaphthoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
    Publication number: 20050137249
    Abstract: The present invention relates to 1- or 3-thiabenzonaphthoazulene derivafives to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-alpha (TNF-alpha) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
    Type: Application
    Filed: April 9, 2003
    Publication date: June 23, 2005
    Applicant: PLIVA-ISTRAZIVACKI INSTITUT D.D.D.
    Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic, Ivana Ozimec, Rudolf Trojko
  • 1- or 3-thia-benzonaphthoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
    Publication number: 20050130964
    Abstract: The present invention relates to benzonaphthoazulene derivatives of tiophene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-? (TNF-?) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
    Type: Application
    Filed: October 12, 2004
    Publication date: June 16, 2005
    Applicant: Pliva-Istrazivacki Institut d.o.o.
    Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic, Ivana Ozimec, Rudolf Trojko
  • 1-oxa 3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof
    Publication number: 20050130956
    Abstract: The present invention relates to derivatives of 1-oxa-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumour necrosis factor-? (TNF-?) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
    Type: Application
    Filed: October 13, 2004
    Publication date: June 16, 2005
    Applicant: Pliva-Istrazivacki Institut d.o.o.
    Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic, Iva Benko
  • 2- thia-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
    Publication number: 20050131056
    Abstract: The present invention relates to compounds of 2-thia-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-? (TNF-?) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
    Type: Application
    Filed: October 12, 2004
    Publication date: June 16, 2005
    Applicant: Pliva-Istrazivacki Institut d.o.o.
    Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic, Ivana Ozimec
  • Thienodibenzoazulene compounds as tumor necrosis factor inhibitors
    Patent number: 6897211
    Abstract: The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-?) and interleukine 1 (IL-1) in mammals at all diseases and conditions where these mediators are excessively secreted. The compounds of the present invention also demonstrate an analgetic action and can be used to relieve pain.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: May 24, 2005
    Assignee: Pliva-Istrazivacki Institut d.o.o.
    Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic, Zeljko Zupanovic, Boska Hrvacic
  • Compounds with anti-inflammatory activity
    Publication number: 20050080003
    Abstract: The present invention relates to new compounds represented by Formula I: wherein M represents a macrolide subunit of the substructure II: L represents the chain of the substructure III: —X1—(CH2)m-Q-(CH2)n—X2—??III D represents the steroid or nonsteroidal subunit derived from steroid or nonsteroidal (NSAID) drugs with anti-inflammatory activity; The present invention relates also to pharmaceutically acceptable salts and solvates of such prepared compounds, to processe and intermediates for their preparation, as well as to the improved therapeutic action and the use in the treatment of inflammatory diseases and conditions in humans and animals.
    Type: Application
    Filed: April 22, 2004
    Publication date: April 14, 2005
    Inventors: Mladen Mercep, Milan Mesic, Linda Tomaskovic, Stribor Markovic, Boska Hrvacic, Oresta Makaruha, Visnja Poljak
  • Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use
    Publication number: 20040097434
    Abstract: The present invention relates (a) to new compounds represented by Formula I: 1
    Type: Application
    Filed: July 7, 2003
    Publication date: May 20, 2004
    Applicant: PLIVA Pharmaceutical Industry, Incorporated
    Inventors: Mladen Mercep, Milan Mesic, Linda Tomaskovic, Stribor Markovic
  • Novel compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules
    Publication number: 20040077612
    Abstract: The present invention relates (a) to new compounds represented by Formula I: 1
    Type: Application
    Filed: July 8, 2003
    Publication date: April 22, 2004
    Applicant: Pliva dd
    Inventors: Mladen Mercep, Milan Mesic, Linda Tomaskovic, Stribor Markovic
  • Compounds, compositions and methods for treatment of inflammatory diseases and conditions
    Publication number: 20040014685
    Abstract: The present invention relates (a) to new compounds represented by Formula I: 1
    Type: Application
    Filed: July 8, 2003
    Publication date: January 22, 2004
    Applicant: PLIVA Pharmaceutical Industry, Incorporated
    Inventors: Mladen Mercep, Milan Mesic, Linda Tomaskovic, Stribor Markovic, Oresta Makaruha, Visnja Poljak
  • Thienodibenzoazulene compounds as tumor necrosis factor inhibitors
    Publication number: 20030153750
    Abstract: The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-&agr;) and interleukine 1 (IL-1) in mammals at all diseases and conditions where these mediators are excessively secreted. The compounds of the present invention also demonstrate an analgetic action and can be used to relieve pain.
    Type: Application
    Filed: November 18, 2002
    Publication date: August 14, 2003
    Applicant: Pliva farmaceutska industrija, dionicko drustvo
    Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic, Zeljko Zupanovic, Boska Hrvacic