Patents by Inventor Mladen Vinkovic
Mladen Vinkovic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9428439Abstract: The invention provides an acid addition salt of a compound of the formula (1). Also provided by the invention are processes for preparing the compound of formula (1) and alkyl analogs thereof, novel intermediates for use in the process and methods for preparing the intermediates. The invention also provides new medical uses of compounds of the formula (1) and its ethyl analog.Type: GrantFiled: January 7, 2014Date of Patent: August 30, 2016Assignee: ASTEX THERAPEUTICS LTD.Inventors: Martyn Frederickson, John Francis Lyons, Neil Thomas Thompson, Mladen Vinkovic, Brian John Williams, Andrew James Woodhead, Alison Jo-Anne Woolford
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Publication number: 20140221394Abstract: The invention provides an acid addition salt of a compound of the formula (1). Also provided by the invention are processes for preparing the compound of formula (1) and alkyl analogues thereof, novel intermediates for use in the process and methods for preparing the intermediates. The invention also provides new medical uses of compounds of the formula (1) and its ethyl analogue.Type: ApplicationFiled: January 7, 2014Publication date: August 7, 2014Applicant: Astex Therapeutic Ltd.Inventors: Martyn Frederickson, John Francis Lyons, Neil Thomas Thompson, Mladen Vinkovic, Brian John Williams, Andrew James Woodhead, Alison Jo-Anne Woolford
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Patent number: 8778936Abstract: The invention provides a compound of the formula (I): or a salt, solvate, tautomer or N-oxide thereof, wherein M is selected from a group D1 and a group D2: and R?, E, A and X are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds, processes for making the compounds and the use of the compounds in the prophylaxis or treatment of a disease state mediated by a CDK kinase, GSK-3 kinase or Aurora kinase.Type: GrantFiled: December 19, 2011Date of Patent: July 15, 2014Assignee: Astex Therapeutics LimitedInventors: Valerio Berdini, Maria Grazia Carr, Adrian Liam Gill, Steven Howard, Eva Figueroa Navarro, Gary Trewartha, David Charles Rees, Mladen Vinkovic, Paul Graham Wyatt
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Patent number: 8653084Abstract: The invention provides an acid addition salt of a compound of the formula (1) Also provided by the invention are processes for preparing the compound of formula (1) and alkyl analogues thereof, novel intermediates for use in the process and methods for preparing the intermediates. The invention also provides new medical uses of compounds of the formula (1) and its ethyl analogue.Type: GrantFiled: October 12, 2007Date of Patent: February 18, 2014Assignee: Astex Therapeutics Ltd.Inventors: Martyn Frederickson, Mladen Vinkovic, Andrew James Woodhead, Alison Jo-Anne Woolford, Marian Williams
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Patent number: 8293767Abstract: The invention provides an acid addition salt of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and crystals thereof, the salt being formed with an acid selected from methanesulphonic acid and acetic acid and mixtures thereof. Also provided are the novel uses of salts of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide, processes for the preparation of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and its salts and novel chemical intermediates.Type: GrantFiled: July 22, 2011Date of Patent: October 23, 2012Assignee: Astex Therapeutics LimitedInventors: Paul Graham Wyatt, David Charles Rees, Mladen Vinkovic, Gary Trewartha
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Publication number: 20120190673Abstract: The invention provides a compound of the formula (I): or a salt, solvate, tautomer or N-oxide thereof, wherein M is selected from a group D1 and a group D2: and R?, E, A and X are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds, processes for making the compounds and the use of the compounds in the prophylaxis or treatment of a disease state mediated by a CDK kinase, GSK-3 kinase or Aurora kinase.Type: ApplicationFiled: December 19, 2011Publication date: July 26, 2012Applicant: ASTEX THERAPEUTICS LIMITEDInventors: Valerio BERDINI, Maria Grazia CARR, Adrian Liam GILL, Steven HOWARD, Eva Figueroa NAVARRO, Gary TREWARTHA, David Charles REES, Mladen VINKOVIC, Paul Graham WYATT
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Patent number: 8110573Abstract: The invention provides a compound of the formula (I): or a salt, solvate, tautomer or N-oxide thereof, wherein M is selected from a group D1 and a group D2: and R?, E, A and X are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds, processes for making the compounds and the use of the compounds in the prophylaxis or treatment of a disease state mediated by a CDK kinase, GSK-3 kinase or Aurora kinase.Type: GrantFiled: December 30, 2005Date of Patent: February 7, 2012Assignee: Astex Therapeutics LimitedInventors: Valerio Berdini, Maria Grazia Carr, Adrian Liam Gill, Steven Howard, Eva Figueroa Navarro, Gary Trewartha, David Charles Rees, Mladen Vinkovic, Paul Graham Wyatt
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Publication number: 20110274616Abstract: The invention provides an acid addition salt of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and crystals thereof, the salt being formed with an acid selected from methanesulphonic acid and acetic acid and mixtures thereof. Also provided are the novel uses of salts of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide, processes for the preparation of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and its salts and novel chemical intermediates.Type: ApplicationFiled: July 22, 2011Publication date: November 10, 2011Applicant: ASTEX THERAPEUTICS LIMITEDInventors: Paul Graham WYATT, David Charles REES, Mladen VINKOVIC, Gary TREWARTHA
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Patent number: 8013163Abstract: The invention provides an acid addition salt of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and crystals thereof, the salt being formed with an acid selected from methanesulphonic acid and acetic acid and mixtures thereof. Also provided are the novel uses of salts of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide, processes for the preparation of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and its salts and novel chemical intermediates.Type: GrantFiled: January 20, 2006Date of Patent: September 6, 2011Assignee: Astex Therapeutics LimitedInventors: Paul Graham Wyatt, David Charles Rees, Mladen Vinkovic, Gary Trewartha
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Publication number: 20110046155Abstract: The invention provides an acid addition salt of a compound of the formula (1) Also provided by the invention are processes for preparing the compound of formula (1) and alkyl analogues thereof, novel intermediates for use in the process and methods for preparing the intermediates. The invention also provides new medical uses of compounds of the formula (1) and its ethyl analogue.Type: ApplicationFiled: October 12, 2007Publication date: February 24, 2011Inventors: Martyn Frederickson, John Francis Lyons, Neil Thomas Thompson, Mladen Vinkovic, Brian John Williams, Marian Williams, Andrew James Woodhead, Alison Jo-Anne Woolford
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Publication number: 20090318500Abstract: The invention provides the compound of formula (I) 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid (1-methanesulphonyl-piperidin-4-yl)-amide in a substantially crystalline form, therapeutic uses thereof and pharmaceutical compositions containing the crystalline compound. The invention also provides novel pharmaceutical formulations containing 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid (1-methanesulphonyl-piperidin-4-yl)-amide and novel processes for preparing the compound.Type: ApplicationFiled: May 4, 2007Publication date: December 24, 2009Applicant: Astex Therapeutics limitedInventors: Gary Trewartha, Eva Figueroa Navarro, David Charles Rees, Mladen Vinkovic, Andrew James Woodhead, Paul Graham Wyatt
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Publication number: 20090275047Abstract: The invention provides the crystal structure of the solAC catalytic domain. The structure is set out in Tables 1 to 5. The structure may be used in to model the interaction of ligands such as pharmaceutical compounds with this protein, and to determine the structure of related adenylate cyclase molecules.Type: ApplicationFiled: July 21, 2006Publication date: November 5, 2009Inventors: Susanne Maria Saalau-Bethell, Anne Cleasby, Joseph Coyle, Mladen Vinkovic, Tracey Ann Sambrook
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Patent number: 7569549Abstract: Substantially pure isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A having the Formula I: wherein S is an organic solvent which is at least partially miscible with water, x is 1, 1.25, 1.5 or 2, y is 0, 0.5, or 1, the pseudopolymorph being characterized by the monoclinic space group P21 and average unit cell parameters comprising: crystal axis lengths of a=15.5-17.0 ?, b=15.5-17.0 ?, and c=17.5-19.5 ?, and angles between the crystal axes of ?=?=90° and ?=106°-112°. In addition, this disclosure is directed to processes for the preparation of the substantially pure isostructural pseudopolymorphs of Formula I; to pharmaceutical compositions containing substantially pure isostructural pseudopolymorphs of Formula I; and to a method for the treatment of bacterial and protozoan infections, and inflammation-related diseases by administration of a pharmaceutical composition containing the substantially pure isostructural pseudopolymorphs of Formula I.Type: GrantFiled: March 17, 2003Date of Patent: August 4, 2009Assignee: Pliva Hrvatska D.O.O.Inventors: Miljenko Dumic, Mladen Vinkovic, Marina Oresic, Ernest Mestrovic, Aleksandar Danilovski, Alojz Dumbovic, Zdravka Knezevic, Gorjana Lazarevski, Dominik Cincic, Darko Filic, Katica Lazaric, Dejan Kresimir Bucar
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Publication number: 20090012124Abstract: The invention provides an acid addition salt of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and crystals thereof, the salt being formed with an acid selected from methanesulphonic acid and acetic acid and mixtures thereof. Also provided are the novel uses of salts of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide, processes for the preparation of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and its salts and novel chemical intermediates.Type: ApplicationFiled: January 20, 2006Publication date: January 8, 2009Applicant: ASTEX THERAPEUTICS LIMITEDInventors: Paul Graham Wyatt, David Charles Rees, Mladen Vinkovic, Gary Trewartha
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Publication number: 20080132495Abstract: The invention provides a compound of the formula (I): or a salt, solvate, tautomer or N-oxide thereof, wherein M is selected from a group D1 and a group D2: and R?, E, A and X are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds, processes for making the compounds and the use of the compounds in the prophylaxis or treatment of a disease state mediated by a CDK kinase, GSK-3 kinase or Aurora kinase.Type: ApplicationFiled: December 30, 2005Publication date: June 5, 2008Applicant: ASTEX THERAPEUTICS LIMITEDInventors: Valerio Berdini, Maria Grazia Carr, Adrian Liam Gill, Steven Howard, Eva Figueroa Navarro, Gary Trewartha, David Charles Rees, Mladen Vinkovic, Paul Graham Wyatt
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Publication number: 20040092460Abstract: Substantially pure amorphous 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A.Type: ApplicationFiled: July 21, 2003Publication date: May 13, 2004Applicant: Pliva Pharmaceutical Industry, IncorporatedInventors: Miljenko Dumic, Mladen Vinkovic, Marina Oresic, Ernest Mestrovic, Aleksandar Danilovski, Alojz Dumbovic, Knezevic Zdravka, Gorjana Lazarevski, Darko Filic, Dominik Cincic, Katica Lazaric, Dejan-Kresimir Bucar
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Publication number: 20040014951Abstract: Substantially pure isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A having the Formula I: 1Type: ApplicationFiled: March 17, 2003Publication date: January 22, 2004Applicant: PLIVA, d.d.Inventors: Miljenko Dumic, Mladen Vinkovic, Marina Oresic, Ernest Mestrovic, Aleksandar Danilovski, Alojz Dumbovic, Zdravka Knezevic, Gorjana Lazarevski, Dominik Cincic, Darko Filic, Katica Lazaric, Dejan Kresimir Bucar
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Patent number: 6369035Abstract: The invention relates to novel compounds from the class of macrolide antibiotics. Particularly, the invention relates to novel 3,6-heiketals from the class of 9a-azalides, to their pharmaceutically acceptable addition salts with inorganic or organic acids, to a process for their preparation and to the use thereof as antibiotics or as intermediates for the synthesis of other macrolide antibiotics.Type: GrantFiled: April 17, 2000Date of Patent: April 9, 2002Assignee: Pliva, farmaceutska industrja, dioni{haeck over (c)}ko dru{haeck over (s)}tvoInventors: Gabrijela Kobrehel, Gorjana Lazarevski, Mladen Vinkovic
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Patent number: 5635529Abstract: Novel O-substituted or O-unsubstituted 6-sulfonamido-1,3-dioxepane-5-ols having hypoglycemic activity are obtained from 6-amino-1,3-dioxepane-5-ol, tetrahydro-6H-[1,3]-dioxepino[5,6-d]oxazole, 5,6-epoxy-1,3-dioxepane or N-sulfonyl-tetrahydro-1H,4H-[1,3]-dioxepino[5,6-b]azirine as starting materials.Type: GrantFiled: February 17, 1995Date of Patent: June 3, 1997Assignee: PLIVA farmaceutska, kemijska, prehrambena i kozmeticka industrija, dionicko drustvo ZagrebInventors: Miljenko Dumic, Darko Filic, Mladen Vinkovic, Blanka Jamnicky