Patents by Inventor Mo Deng

Mo Deng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High speed single-frame label-free cell tomography
    Patent number: 12711699
    Abstract: A SIngle-frame LAbel-free Cell Tomography (SILACT) system and methods are provided to reconstruct 3D Refractive Index (RI) distribution of cells at over 10,000 volumes/second while resolving subcellular compartments without fluorescence labelling. The SILACT includes a high-speed interference microscope with multiplex illumination and a fast reconstruction method utilizing a pre-trained physics-incorporating Deep Neural Network (DNN). With SILACT, it is demonstrated that 3D imaging cytometry at a throughput of over 20,000 cells/second can be achieved, and transient dynamics of Red Blood Cells (RBCs) undergoing shear-induced 3D deformation inside a microfluidic channel can be observed.
    Type: Grant
    Filed: December 15, 2022
    Date of Patent: August 18, 2026
    Assignees: The Chinese University of Hong Kong, Massachusetts Institute of Technology
    Inventors: Renjie Zhou, Yanping He, Peter T. C. So, Baoliang Ge, George Barbastathis, Mo Deng, Zahid Yaqoob
  • HIGH SPEED SINGLE-FRAME LABEL-FREE CELL TOMOGRAPHY
    Publication number: 20230186558
    Abstract: A SIngle-frame LAbel-free Cell Tomography (SILACT) system and methods are provided to reconstruct 3D Refractive Index (RI) distribution of cells at over 10,000 volumes/second while resolving subcellular compartments without fluorescence labelling. The SILACT includes a high-speed interference microscope with multiplex illumination and a fast reconstruction method utilizing a pre-trained physics-incorporating Deep Neural Network (DNN). With SILACT, it is demonstrated that 3D imaging cytometry at a throughput of over 20,000 cells/second can be achieved, and transient dynamics of Red Blood Cells (RBCs) undergoing shear-induced 3D deformation inside a microfluidic channel can be observed.
    Type: Application
    Filed: December 15, 2022
    Publication date: June 15, 2023
    Inventors: Renjie Zhou, Yanping He, Peter T.C. So, Baoliang Ge, George Barbastathis, Mo Deng, Zahid Yaqoob