Abstract: Systems, methods and computer-readable memory devices are provided for greater efficiency in the configuration of a database cluster for performing a query workload. A database cluster configuration system is provided that includes a database cluster comprising one or more compute resources configured to perform database queries. A query workload comprising a plurality of queries is received. An initial workload-level configuration is applied. For each query of the query workload, a query-level configuration is generated using a query configuration model corresponding to each query in a contextual Bayesian optimization with centroid learning while also leveraging the query plan for each executing query for query characterization and including application of virtual operators. Query events are collected and used to update the corresponding query configuration model. The workload-level configuration is updated based on the query events and cached for use during a subsequent execution of the workload.

Abstract: The present invention discloses a composite-type nano-vaccine particle, which comprises an active ingredient selected from spike RBD protein of COVID-19, two adjuvants as aluminium salt nanoparticle and synthetic oligonucleotides, and an amphiphilic alginate-based nanocarrier encapsulating the active ingredient and the two adjuvants. The composite-type nano-vaccine particle has a particle size ranging from 300 nm to 1400 nm in diameter.

Abstract: This invention discloses an injectable nanocomposite gel composition and the method of making the composition. The composition is composed of amphiphilic alginate nanoparticle, gel stabilizer, gel crosslinker, and gel structural modifiers. The nanocomposite gel can be manufactured into a form of highly-viscous gel or a solid-like gel, used as a vehicle to carry and deliver pharmaceutically active ingredients with high drug load via injection administration for medical uses.

Abstract: A total demand model can be trained, by machine learning and using historical data. The total demand model can be configured to process current data and output first data indicating a predicted future total demand for a product. A target demand model can be trained. The target demand model can be configured to process the current data and, based on processing the current data, output a plurality of class demand models. Each class demand model can be configured to predict demand, for each of a plurality of future time periods, for a plurality of classes of the product. The class demand models configured to optimize, for each of the plurality of future time periods, a respective set of optimal prices for the respective classes of the product that maximizes total expected revenue for the product over the plurality of classes of the product.

Abstract: Methods and apparatus relating to liquid-proof edge connector solutions for immersion cooling are described. In one embodiment, a seal prevents a cooling liquid to cause electrical contact with a pin of an edge card to be inserted in a connector. And, an adhesive prevents the cooling liquid to cause electrical contact with a terminal of the connector. Other embodiments are also claimed and disclosed.

Abstract: This invention discloses an injectable nanocomposite gel composition and the method of making the composition. The composition is composed of amphiphilic alginate nanoparticle, gel stabilizer, gel crosslinker, and gel structural modifiers. The nanocomposite gel can be manufactured into a form of highly-viscous gel or a solid-like gel, used as a vehicle to carry and deliver pharmaceutically active ingredients with high drug load via injection administration for medical uses.

Abstract: The present disclosure provides a dual-drag-containing nanoparticle, in which a first antiviral drag, such as remdesivir and a second antiviral drag are co-encapsulated and co-delivered by the nanoparticle, said nanoparticle comprising an alginate-oleic acid particle. The disclosure also relates to the therapeutic use of the nanoparticle in treating viral infections, such as SARS-CoV-2.

Abstract: A substance delivery mask includes a body, an exhaling valve, an inhaled valve, and a fog module. The fog module comprises a controlling module, a container, and an atomizer. The controlling module is disposed on the body. The container is disposed on the controlling module, the container is storing a mixed liquid, and the mixed liquid includes water and a plurality of nanoparticles. The atomizer is disposed on the container, the atomizer is used to atomize the water of the mixed liquid to form fog particles, and the fog particles are wrapped several of the nanoparticles respectively. The substance delivery mask can encapsulate the water-soluble or water-insoluble medicines, or nutritional products in the fog particles generated from the atomizer. The present invention can deliver medicine, nutritional products or vaccines by inhalation or oral.

Abstract: The present invention provides a new type of hydrophobically -modified sodium alginate, which is synthesized by alginate and oleic acid linked with a spacer. The AGO macromolecule as obtained therefrom is amphiphilic and has clinically-accessible molecular size, and anti- cancer activity. The AGO nanoparticle formed therefrom shows excellent structural stability, colloidal stability, and biocompatibility in-vitro and in-vivo, and is expected to be useful in biomedical area, for example, used as a drug delivery system.

Abstract: A nanodrug particle includes alginate and a camptothecin compound. The camptothecin compound is grafted onto the alginate, and the alginate and the camptothecin compound self-assemble and form a nanosphere. The disclosure also provides a method for preparing a nanodrug particle; the method includes: modifying alginate to form alginate having amine groups; modifying a camptothecin compound to form a camptothecin compound having a carboxyl group; forming a camptothecin-alginate polymer by reacting the alginate having amine groups with the camptothecin compound having a carboxyl group, wherein the camptothecin-alginate polymer self-assembles in an aqueous solution and forms a nanosphere.

Abstract: An apparatus and method for reducing differential cross-talk in a pin arrangement of a socket are described. Socket pins within a differential pair use a modified shape to tighten the intra-pair pin coupling to reduce the crosstalk without changing the pin map. The middle vertical segment of one pin of a diagonally adjacent differential pin pair is modified to be closer to the other pin than other corresponding locations of the pins. The spring beam that extends from the middle vertical segment of the one pin is modified to accommodate the package landing pad that the spring beam contacts to maintain a uniform pitch.

Abstract: The present invention discloses a composite-type nano-vaccine particle, which comprises an active ingredient selected from spike RBD protein of COVID-19, two adjuvants as aluminium salt nanoparticle and synthetic oligonucleotides, and an amphiphilic alginate-based nanocarrier encapsulating the active ingredient and the two adjuvants. The composite-type nano-vaccine particle has a particle size ranging from 300 nm to 1400 nm in diameter.

Abstract: The present invention provides a virus collection matrix, including: a porous gel or fibrous structure formed by a positively charged polymer material; and a plurality of ACE 2 receptors. The plurality of ACE 2 receptors are negatively charged, and distributed and covered on the surface of the porous gel or fibrous structure. The whole virus collection matrix is positively charged.

Abstract: The present invention relates to a drug composition and method for treating breast cancer, and more specifically, to use carboxymethyl-hexanoyl chitosan (CHC) to co-encapsulate a heat shock protein 90 (HSP90) inhibitor and a hydrophobic drug. The two drugs can be co-encapsulated with high encapsulation efficiency and co-delivered to breast cancerous cells, and achieve a synergistic efficacy to kill the cancerous cells.

Abstract: In one embodiment, a card edge connector includes a housing including a slot to receive a first circuit board. A first plurality of pins extend from within the slot through a bottom of the housing. Each of the first plurality of pins includes a first end to mate with a corresponding contact of the first circuit board and a second end to mate with a corresponding one of a first plurality of contacts of a second circuit board, the second end including a heel portion and a toe portion extending from the heel portion in a direction away from a centerline of the slot. A second plurality of pins extend from within the slot through the bottom of the housing.

Abstract: An amphiphilic polymer, an amphiphilic polymer manufacturing method, a contact lens material including the amphiphilic polymer, and contact lens manufacturing method are provided. The amphiphilic polymer includes poly(dimethylsiloxane) and amphiphilic chitosan bonded to the same. The contact lens material includes the amphiphilic polymer. The amphiphilic polymer manufacturing method includes providing a poly(dimethylsiloxane), providing an amphiphilic chitosan, and bonding the amphiphilic chitosan to the poly(dimethylsiloxane).

Abstract: In one embodiment, a card edge connector includes: a housing having an opening into which a first circuit board is to be inserted; a plurality of pins each having a first end and a second end, the plurality of pins extending from within the opening through a bottom surface of the housing, the first end of the first plurality of pins to mate with a corresponding contact of the first circuit board; and a plurality of ball grid array (BGA) solder balls each adapted at the second end of a corresponding one of the plurality of pins, the plurality of pins to mate with a corresponding conductive area of a second circuit board to which the card edge connector mates via the plurality of BGA solder balls. Other embodiments are described and claimed.

Abstract: Disclosed herein is a ganetespib-containing particle, which includes an active ingredient selected from ganetespib, a pharmaceutically acceptable salt of ganetespib, and a combination thereof, and an amphiphilic chitosan-based carrier carrying the active ingredient. Also disclosed herein are a pharmaceutical composition including the ganetespib-containing particle, and use of such pharmaceutical composition in treating cancer.

Abstract: An amphiphilic polymer, an amphiphilic polymer manufacturing method, use of an amphiphilic polymer as a contact lens material, and a contact lens material including the same are provided. The amphiphilic polymer includes amino-conjugated mono-HEMA (mHEMA-NH2) and amphiphilic chitosan bonded to the same. The amphiphilic polymer manufacturing method includes providing a mHEMA-NH2, providing an amphiphilic chitosan, and bonding the mHEMA-NH2 to the amphiphilic chitosan.

Abstract: Embodiments may relate to a connector. The connector may include a plurality of connector pins that are to communicatively couple an element of a printed circuit board (PCB) with an element of an electronic device when the element of the PCB and the element of the electronic device are coupled with the connector. The connector may also include an active circuit that is communicatively coupled with a pin of the plurality of pins. The active circuit may be configured to match an impedance of the element of the PCB with an impedance of the element of the electronic device. Other embodiments may be described or claimed.