Patents by Inventor Modesto Erneta
Modesto Erneta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130005829Abstract: Novel semi-crystalline, epsilon-caprolactone-rich block copolymers of epsilon-caprolactone and p-dioxanone for long term absorbable medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, and other medical devices. Also disclosed are compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease.Type: ApplicationFiled: October 14, 2011Publication date: January 3, 2013Applicant: Advanced Technologies and Regenerative Medicine, LLC.Inventors: Dennis D. Jamiolkowski, Sasa Andjelic, Modesto Erneta
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Publication number: 20130006349Abstract: Compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease are disclosed.Type: ApplicationFiled: June 30, 2011Publication date: January 3, 2013Inventors: Iksoo Chun, Ziwei Wang, Kevin Cooper, Dennis Jamiolkowski, Modesto Erneta, Sasa Andjelic, Jianguo Jack Zhou
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Patent number: 8278409Abstract: Copolymers exhibiting the following combinations of properties, including without limitation, ?-caprolactone in an amount ranging from about 12 to about 70 mole percent, glycolide in an amount ranging from about 30 to about 88 mole percent, crystallinity ranging from about 10 to about 50% as measured by WAXD or about 10 to about 50 J/g as measured by DSC, and an inherent viscosity ranging from about 0.5 to about 1.45 dL/g as measured in a 0.1 g/dl solution of HFIP at 25° C.; a method for melt blowing such copolymers and nonwoven constructs produced therefrom are described herein.Type: GrantFiled: April 22, 2008Date of Patent: October 2, 2012Assignee: Ethicon, Inc.Inventors: Modesto Erneta, Dennis D. Jamiolkowski, Jianguo Jack Zhou, Sasa Andjelic
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Patent number: 8211850Abstract: Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.Type: GrantFiled: March 30, 2011Date of Patent: July 3, 2012Assignee: Johnson & Johnson Consumer Companies, Inc.Inventors: Sasa Andjelic, Modesto Erneta, Michael J. Fevola, Frank C. Sun
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Publication number: 20120123103Abstract: Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.Type: ApplicationFiled: March 30, 2011Publication date: May 17, 2012Inventors: Sasa Andjelic, Modesto Erneta, Michael J. Fevola, Frank C. Sun
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Publication number: 20120122755Abstract: Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.Type: ApplicationFiled: March 30, 2011Publication date: May 17, 2012Inventors: Sasa Andjelic, Modesto Erneta, Michael J. Fevola, Frank C. Sun
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Publication number: 20120122758Abstract: Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.Type: ApplicationFiled: March 30, 2011Publication date: May 17, 2012Inventors: Sasa Andjelic, Modesto Erneta, Michael J. Fevola, Frank C. Sun
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Publication number: 20120123104Abstract: Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.Type: ApplicationFiled: March 30, 2011Publication date: May 17, 2012Inventors: Sasa Andjelic, Modesto Erneta, Michael J. Fevola, Frank C. Sun
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Patent number: 7968656Abstract: A semi-crystalline, absorbable copolyester composition comprising the reaction product of a polycondensation polyester and at least one lactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and diethylene glycol; and the copolyester comprises about 30 to 60% by weight of the polycondensation polyester based on the total weight of the copolyester. Also medical devices such as absorbable sutures comprising such copolyesters and absorbable microspheres comprising such copolyesters and methods of making of such absorbable microspheres. Additionally, a method of melt blowing an absorbable copolyester composition and a nonwoven construct are disclosed.Type: GrantFiled: April 22, 2008Date of Patent: June 28, 2011Assignee: Ethicon, Inc.Inventors: Sasa Andjelic, Jiango Jack Zhou, Modesto Erneta, Michel Gensini
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Patent number: 7964211Abstract: The present invention is directed to absorbable microspheres comprising a copolymer formed from greater than 88 to about 99 mole percent ?-caprolactone or p-dioxanone, and about 1 to less than 12 mole percent of a different second monomer selected from the group consisting of glycolide, p-dioxanone, trimethylene carbonate and the lactides and combinations thereof, said microspheres having a particle size ranging from about 5 to 2,000 microns. Also described herein are a method for making such microspheres and formulations comprising such absorbable microspheres.Type: GrantFiled: June 3, 2010Date of Patent: June 21, 2011Assignee: Ethicon, Inc.Inventors: Modesto Erneta, Zhangwen Wu
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Patent number: 7868127Abstract: A semi-crystalline, absorbable copolyester composition comprising the reaction product of a polycondensation polyester and at least one lactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and diethylene glycol; and the copolyester comprises about 30 to 60% by weight of the polycondensation polyester based on the total weight of the copolyester. Also medical devices such as absorbable sutures comprising such copolyesters and absorbable microspheres comprising such copolyesters and methods of making of such absorbable microspheres.Type: GrantFiled: March 29, 2007Date of Patent: January 11, 2011Assignee: Ethicon, Inc.Inventors: Sasa Andjelic, Modesto Erneta, Michel Gensini
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Publication number: 20100240859Abstract: The present invention is directed to absorbable microspheres comprising a copolymer formed from greater than 88 to about 99 mole percent ?-caprolactone or p-dioxanone, and about 1 to less than 12 mole percent of a different second monomer selected from the group consisting of glycolide, p-dioxanone, trimethylene carbonate and the lactides and combinations thereof, said microspheres having a particle size ranging from about 5 to 2,000 microns. Also described herein are a method for making such microspheres and formulations comprising such absorbable microspheres.Type: ApplicationFiled: June 3, 2010Publication date: September 23, 2010Inventors: Modesto Erneta, Zhangwen Wu
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Publication number: 20100204411Abstract: An antimicrobial composition comprising an ionic complex of an anionic polyester with an antimicrobial metal, wherein the anionic polyester has an ion exchange capacity from about 0.19 meq/g to about 1.0 meq/g.Type: ApplicationFiled: January 15, 2010Publication date: August 12, 2010Applicant: ETHICON, INCInventors: Modesto Erneta, Robert DiLuccio
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Publication number: 20090264040Abstract: Copolymers exhibiting the following combinations of properties, including without limitation, ?-caprolactone in an amount ranging from about 12 to about 70 mole percent, glycolide in an amount ranging from about 30 to about 88 mole percent, crystallinity ranging from about 10 to about 50% as measured by WAXD or about 10 to about 50 J/g as measured by DSC, and an inherent viscosity ranging from about 0.5 to about 1.45 dL/g as measured in a 0.1 g/dl solution of HFIP at 25° C.; a method for melt blowing such copolymers and nonwoven constructs produced therefrom are described herein.Type: ApplicationFiled: April 22, 2008Publication date: October 22, 2009Applicant: ETHICON, INC.Inventors: Modesto Erneta, Dennis D. JAMIOLKOWSKI, Jianguo Jack ZHOU, Sasa ANDJELIC
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Publication number: 20090104276Abstract: A semi-crystalline, absorbable copolyester composition comprising the reaction product of a polycondensation polyester and at least one lactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and diethylene glycol; and the copolyester comprises about 30 to 60% by weight of the polycondensation polyester based on the total weight of the copolyester. Also medical devices such as absorbable sutures comprising such copolyesters and absorbable microspheres comprising such copolyesters and methods of making of such absorbable microspheres. Additionally, a method of melt blowing an absorbable copolyester composition and a nonwoven construct are disclosed.Type: ApplicationFiled: April 22, 2008Publication date: April 23, 2009Applicant: ETHICON, INC.Inventors: Sasa ANDJELIC, Jianguo Jack ZHOU, Modesto ERNETA, Michel GENSINI
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Publication number: 20090092648Abstract: An antimicrobial composition.Type: ApplicationFiled: October 9, 2007Publication date: April 9, 2009Applicant: ETHICON, INC.Inventors: Modesto ERNETA, Joerg PRIEWE
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Publication number: 20080103285Abstract: A semi-crystalline, absorbable copolyester composition comprising the reaction product of a polycondensation polyester and at least one lactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and diethylene glycol; and the copolyester comprises about 30 to 60% by weight of the polycondensation polyester based on the total weight of the copolyester. Also medical devices such as absorbable sutures comprising such copolyesters and absorbable microspheres comprising such copolyesters and methods of making of such absorbable microspheres.Type: ApplicationFiled: March 29, 2007Publication date: May 1, 2008Inventors: Sasa Andjelic, Modesto Erneta, Michel Gensini
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Publication number: 20070298113Abstract: The present invention is directed to absorbable microspheres comprising a copolymer formed from greater than 88 to about 99 mole percent ?-caprolactone or p-dioxanone, and about 1 to less than 12 mole percent of a different second monomer selected from the group consisting of glycolide, p-dioxanone, trimethylene carbonate and the lactides and combinations thereof, said microspheres having a particle size ranging from about 5 to 2,000 microns. Also described herein are a method for making such microspheres and formulations comprising such absorbable microspheres.Type: ApplicationFiled: June 22, 2006Publication date: December 27, 2007Inventors: Modesto Erneta, Zhangwen Wu
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Patent number: 7148315Abstract: Monomer addition methodology is provided to adjust monomer addition rates to a polymerization reactor. Advantages of the invention include control of bioabsorbable copolymer structure, improvement of monomer conversion, control of reaction temperature, and reduced reaction time. The overall result is an improved process and enhanced product performance. The technology is particularly useful in the copolymerization of monomers with different reactivity ratios, such as glycolide/lactide copolymers and glycolide/caprolactone copolymers. Monomer reactivity ratios and reaction kinetics are utilized to adjust monomer addition rates.Type: GrantFiled: October 23, 2002Date of Patent: December 12, 2006Assignee: Ethicon, Inc.Inventors: Modesto Erneta, Terry E. Lawler
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Publication number: 20040082755Abstract: Monomer addition methodology is provided to adjust monomer addition rates to a polymerization reactor. Advantages of the invention include control of bioabsorbable copolymer structure, improvement of monomer conversion, control of reaction temperature, and reduced reaction time. The overall result is an improved process and enhanced product performance. The technology is particularly useful in the copolymerization of monomers with different reactivity ratios, such as glycolide/lactide copolymers and glycolide/caprolactone copolymers. Monomer reactivity ratios and reaction kinetics are utilized to adjust monomer addition rates.Type: ApplicationFiled: October 23, 2002Publication date: April 29, 2004Applicant: ETHICON, INC.Inventors: Modesto Erneta, Terry E. Lawler