Patents by Inventor Mohamad-Rami Jaber

Mohamad-Rami Jaber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of multidrug transporters
    Publication number: 20030125337
    Abstract: The present invention relates generally to the fields of bacteriology and mycology. More particularly, the present invention provides novel inhibitors of multidrug transport proteins that may be used in combination with existing antibacterial agent and/or antifungal agents to increase the toxic effects of the antimicrobial agents. More specifically, the present invention provides methods and compositions for enhancing the antibacterial action of fluoroquinolones by administering fluoroquinolones in combination with an inhibitor of multidrug transporters and of enhancing the antifungal action of azole antifungal agents by administering an azole antifungal agent in combination with an inhibitor of multidrug transporters. Compositions comprising indole, urea, quinoline or aromatic amide based inhibitors also are disclosed.
    Type: Application
    Filed: March 26, 2002
    Publication date: July 3, 2003
    Applicant: Influx, Inc.
    Inventors: Penelope N. Markham, Debbie C. Mulhearn, Alexander A. Neyfakh, David Crich, Mohamad-Rami Jaber, Michael E. Johnson
  • Inhibitors of multidrug transporters
    Patent number: 6362229
    Abstract: The present invention relates generally to the fields of bacteriology and mycology. More particularly, the present invention provides novel inhibitors of multidrug transport proteins that may be used in combination with existing antibacterial agent and/or antifungal agents to increase the toxic effects of the antimicrobial agents. More specifically, the present invention provides methods and compositions for enhancing the antibacterial action of fluoroquinolones by administering fluoroquinolones in combination with an inhibitor of multidrug transporters and of enhancing the antifungal action of azole antifungal agents by administering an azole antifungal agent in combination with an inhibitor of multidrug transporters. Compositions comprising indole, urea, quinoline or aromatic amide based inhibitors also are disclosed.
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: March 26, 2002
    Assignee: Influx, Inc.
    Inventors: Penelope N. Markham, Debbie C. Mulhearn, Alexander A. Neyfakh, David Crich, Mohamad-Rami Jaber, Michael E. Johnson
  • Inhibitors of multidrug transporters
    Patent number: 6326391
    Abstract: The present invention relates generally to the fields of bacteriology and mycology. More particularly, the present invention provides novel inhibitors of multidrug transport proteins that may be used in combination with existing antibacterial agent and/or antifungal agents to increase the toxic effects of the antimicrobial agents. More specifically the present invention provides methods and compositions for enhancing the antibacterial action of fluoroquinolones by administering fluoroquinolones in combination with an inhibitor of multidrug transporters and of enhancing the antifungal action of azole antifungal agents by administering an azole antifungal agent in combination with an inhibitor of multidrug transporters. Compositions comprising indole, urea, quinoline or aromatic amide based inhibitors also are disclosed.
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: December 4, 2001
    Assignee: Influx, Inc.
    Inventors: Penelope N. Markham, Debbie C. Mulhearn, Alexander A. Neyfakh, David Crich, Mohamad-Rami Jaber, Michael E. Johnson