Abstract: A grille guard configured to be rotatably attached to a vehicle by a pivot bracket having a first end configured to be attached to a frame of the vehicle and a second end attached to the grille guard. The grille guard is rotatably attached to the frame so as to be movable between an upright configuration where the grille guard extends orthogonally relative to the bumper and a horizontal configuration where the grille guard extends in parallel relative to the bumper. A support assembly including a support member supports the grille guard when the grille guard is in the horizontal configuration.

Abstract: Novel aza analogues of dicationic terphenyl compounds for use in combating microbial infections are described. The compounds include those of Formula (III): wherein one of A1, Y1, and Z1 is N; Ar1 is phenylene; and Ar3 is a nitrogen-containing aromatic group.

Abstract: Novel aza analogues of dicationic terphenyl compounds for use in combating microbial infections are described. Also described are processes for synthesizing the compounds.

Abstract: Novel dicationic terphenyl compounds and their aza analogues. Methods for combating microbial infections with novel dicationic terphenyl compounds and their aza analogues. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues.

Abstract: Disclosed herein are novel dicationic teraryl compounds and their aza analogues, including compounds of Formula (IIe): wherein p and q are each 0 and each A, Y and Z is CR4. An exemplary compound of Formula (IIe) is: Methods for combating microbial infections, such as parasitic Leishmania species, with novel dicationic terphenyl compounds and their aza analogues are included. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues are disclosed along with methods for evaluation of the compounds as potential anti-protozoan agents.

Abstract: Novel dicationic 2,5-diaryl selenophene compounds are described. Also described are novel aza analogues of dicationic 2,5-diaryl thiophenes. The presently disclosed dicationic compounds exhibit in vitro activity versus Trypanosoma brucei rhodesiense, Plasmodium falciparum, and/or Leishmania donovani comparable to that of pentamidine and furamidine. Some of the novel dicationic compounds display good activity in vivo in a murine model of a Trypanosoma brucei rhodesiense infection.

Abstract: Dicationic compounds that are highly selective for binding G-quadruplex DNA are described. Several compounds exhibit groove binding toward G-quadruplex DNA and in vitro and in vivo activity versus Trypanosoma brucei rhodesiense. The compounds represent novel drugs for the treatment of cancer, malaria, leishmania, and trypanosomiasis.

Abstract: Novel dicationic bichalcophene compounds are described. The presently disclosed novel dicationic bichalcophene compounds exhibit in vitro activity versus Trypanosoma brucei rhodesiense, Plasmodium falciparum, or Leishmania donovani comparable to that of pentamidine and furamidine. Some of the novel dicationic bichalcophene compounds displayed good activity in vivo in a murine model of a Trypanosoma brucei rhodesiense infection.

Abstract: A method for treating a microbial infection, including an infection from a protozoan pathogen, such as Trypanosoma brucei rhodesiense and Plasmodium falciparum, in a subject in need thereof by administering to the subject an effective amount of a dicationic imidazopyridine compound or a dicationic tetrahydro-imidazopyridine compound. Processes for synthesizing dicationic imidazopyridines and dicationic tetrahydro-imidazopyridines and the novel dicationic imidazopyridine and dicationic tetrahydro-imidazopyridine compounds themselves.

Abstract: A compound of Formula (I): wherein: X is selected from the group consisting of O, S, and NR17, where R17 is hydrogen or lower alkyl; A and Y are CH, N, NR17, O, or S; C1 and C2 are each C or N, wherein C1 and C2 are the same or different; D1 and D2 are each C or N, wherein D1 and D2 are the same or different; B and Z are CH, N, or NR17, provided that B, Z, or both B and Z are not present when A, Y, or both A and Y are O, S, or NR17; R13, R14, R1 and R8 can be present or absent, and when present are selected from the group consisting of H, lower alkyl, halogen, alkoxyl, aryloxyl, aralkoxy and hydroxyl; R15 and Rare selected from the group consisting of H, lower alkyl, halogen, alkoxyl, aryloxyl, aralkoxy and hydroxyl; R3 and R6 are each independently selected from the group consisting of H, hydroxy, lower alkyl, cycloalkyl, aryl, aralkyl, alkoxyl, hydroxycycloalkyl, alkoxycycloalkyl, hydroxyalkyl, aminoalkyl, acyloxy, acetoxy, and alkylaminoalkyl; and R2, R4, R5 and R7 are each independently selected fr

Abstract: A compound of Formula (I): 1

Abstract: A peeling device supports a fresh commodity in a first position in a nonspecific orientation. The commodity is impelled using a thruster toward a scoring structure for scoring the peel to a predetermined depth into two sectors. Peel grippers hold the peel between the scores and release the peeled commodity, such that the peel is retained on the gripping means. The thruster is positioned and adapted to force the commodity along a path to engage the cutting and peel-gripping elements, the thruster bottom surface changeable from a first, generally concave orientation for conforming to a shape of the commodity to a second, generally convex orientation for releasing the commodity from the peel.

Abstract: A peeling device supports a fresh commodity in a first position in a nonspecific orientation. The commodity is impelled using a thruster toward a scoring structure for scoring the peel to a predetermined depth into two sectors. Peel grippers hold the peel between the scores and release the peeled commodity, such that the peel is retained on the gripping means. The thruster is positioned and adapted to force the commodity along a path to engage the cutting and peel-gripping elements, the thruster bottom surface changeable from a first, generally concave orientation for conforming to a shape of the commodity to a second, generally convex orientation for releasing the commodity from the peel.

Abstract: The system for peeling a fresh commodity includes barbs for piercing the peel in a plurality of spaced-apart locations. A vacuum infuser is used to infuse the pierced commodity with an aqueous solution to loosen the peel. A peeling device supports a fresh commodity in a first position. The commodity is impelled toward a structure having cutting elements for scoring the peel to a predetermined depth. Preferably the scores are made along generally circumferential lines having substantially common endpoints. Peel grippers hold the peel between the scores and release the peeled commodity, such that the peel is retained on the gripping means. A thruster is positioned and adapted to force the commodity along a path to engage the cutting and peel-gripping elements.