Abstract: The present invention relates to use of an antibacterial agent in the manufacture of a medicament for the treatment of osteoarthritis, more particularly for the treatment of a bacterial infection which is responsible for osteoarthritis. Also described are methods for the diagnosis of osteoarthritis through the detection of certain bacteria in an affected joint of a patient with osteoarthritis.

Abstract: The present invention provides a method of screening a library of peptides of formula M-G/M/V—(X)n wherein n is an integer from 3 to 18, M is methionine, G is glycine, V is valine and each X, which may be the same or different, is any genetically encoded amino acid, which method comprises: a) transforming a host cell population with a library of nucleic acid constructs which can express free peptides of formula M-G/M/V—(X)n; b) culturing the transformed host cells under conditions suitable for intra-cellular expression of the peptides of formula M-G/M/V—(X)n; and c) analysing the host cell population to determine the effect of the peptides of formula M-G/M/V—(X)n on a reporter system.

Abstract: The present invention provides a peptide having 2 to 10 amino acids or a derivative thereof which is able to restore wild type function of human p53, for use in therapy; and a method of screening a library of molecules for the ability of members of that library to restore or modify the function of a target protein in an intracellular environment, which method comprises introducing the library into host cells which have a reporter system which allows the identification of those cells in which the function of the target protein has been restored or modified.