Abstract: Among the various aspects of the present disclosure is the provision of a method of treating or preventing kidney disease in a subject in need thereof. Another aspect of the present disclosure provides for a method of reducing a number of kidney cells having excess centrosomes or centrosome amplification (CA) or inhibiting centrosome clustering in a subject having or suspected of having a kidney disease associated with CA or increased centrosome clustering. In some embodiments, the method comprises administering to the subject a centrosome clustering inhibiting agent.