Patents by Inventor Mohamed Naguib Attala

Mohamed Naguib Attala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Melatonin analogue prodrugs
    Patent number: 7381740
    Abstract: Disclosed are compounds that can serve as melatonin analogue prodrugs and that are soluble in aqueous solvents. Melatonin or melatonin analogues having modifications to the indole moiety are coupled to a tertiary amine to form a quaternary amine such that there is a saturated two-carbon linkage between the carbonyl of the melatonin structure and the amine nitrogen. This structure is stable in acidic environments, but is unstable at basic or neutral pH. Therefore, these melatonin analogue prodrugs are stable in a vial at acidic pH, but will breakdown upon injection into the body to liberate the melatonin analogue and the tertiary amine, which is nontoxic. The melatonin analogue being not modified on the indole moiety exerts similar pharmacological properties as melatonin: antioxidation, sedation and anesthesia.
    Type: Grant
    Filed: October 26, 2004
    Date of Patent: June 3, 2008
    Assignee: University of Iowa Research Foundation
    Inventors: Max T. Baker, Mohamed Naguib Attala
  • Composition of melatonin for induction of general anesthesia
    Publication number: 20040002536
    Abstract: Melatonin (N-acetyl-5-methoxytryptamine), or its biologically active analogues, are used to induce anesthesia.
    Type: Application
    Filed: April 22, 2003
    Publication date: January 1, 2004
    Applicant: University of Iowa Research Foundation
    Inventor: Mohamed Naguib Attala
  • Use of melatonin analogues for induction of general anesthesia
    Patent number: 6638966
    Abstract: Melatonin (N-acetyl-5-methoxytryptamine), or its biologically active analogues, are used to induce anesthesia.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: October 28, 2003
    Assignee: University of Iowa Research Foundation
    Inventors: Max T. Baker, Mohamed Naguib Attala
  • Use of melatonin for induction of general anesthesia
    Patent number: 6552064
    Abstract: Melatonin (N-acetyl-5-methoxytryptamine), or its biologically active analogues, are used to induce anesthesia.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: April 22, 2003
    Assignee: University of Iowa Research Foundation
    Inventor: Mohamed Naguib Attala
  • Use of melatonin analogues for induction of general anesthesia
    Publication number: 20020120002
    Abstract: Melatonin (N-acetyl-5-methoxytryptamine), or its biologically active analogues, are used to induce anesthesia.
    Type: Application
    Filed: February 19, 2002
    Publication date: August 29, 2002
    Applicant: University of Iowa Research Foundation
    Inventors: Max T. Baker, Mohamed Naguib Attala
  • Use of melatonin for induction of general anesthesia
    Publication number: 20020035141
    Abstract: Melatonin (N-acetyl-5-methoxytryptamine), or its biologically active analogues, are used to induce anesthesia.
    Type: Application
    Filed: August 10, 2001
    Publication date: March 21, 2002
    Inventor: Mohamed Naguib Attala