Abstract: The disclosure provides for a variable stiffness catheter. The catheter may include an inner layer forming an inner lumen, a middle layer surrounding the inner layer, and an outer layer surrounding the middle layer. The middle layer may form a lumen and may include a plurality of strings within the lumen. The catheter may also include a wrapping weaved through the plurality of strings of the middle layer. Applying a vacuum, actuating by applying negative pressure, or evacuating fluid from the lumen of the middle layer alters a frictional force between the inner layer and the outer layer or between elements of the middle layer and thereby changes the catheter's flexural rigidity over a defined region.

Abstract: Devices, systems, and methods of facilitating airway management with reduced risk of release of droplets and aerosolized pathogens from the lungs of a patient are disclosed, including a bronchoscope adapter for an endotracheal tube, an endotracheal tube with integral bronchoscope adapter, an endotracheal intubation mask system, a laryngeal mask airway-specific mask system, and a quick-seal laryngeal mask airway-specific mask system.

Abstract: Among the various aspects of the present disclosure is the provision of an electrophoresis and electroporation device, system, and methods of use thereof. Devices to administer drugs with electrophoresis and electroporation are described. Systems to administer drugs with an electrophoresis and electroporation device by applying voltages with a power source and controller are also described. Also disclosed are methods of administering a therapeutic agent with an electrophoresis and electroporation device or system.

Abstract: Among the various aspects of the present disclosure is the provision of an aerosol containment mask and methods of use thereof. An aerosol containment mask is described that minimizes aerosol release during insertion or removal of an airway management device or gastric tube. Methods of insertion and removal of an airway management device or gastric tube are also described wherein the aerosol containment mask is employed.

Abstract: An anastomosis device for joining a first and second end of a vascular vessel is disclosed that includes a polymer cylinder ending in opposed first and second vascular-retaining ends configured for insertion into the first and second ends of the vascular vessel respectively. Each vascular-retaining end includes a plurality of bristles protruding outward. The device also includes at least one moiety covalently coupled to the surface of the device. The at least one moiety is selected from at least one anti-coagulant, at least one cell-specific binding peptide, and any combination thereof.

Abstract: The disclosure provides for an adjustable catheter system with isovolumetric suction and restoration of fluid for the removal of a thrombus and a method of use thereof. The catheter system includes an inner catheter and an outer sheath surrounding at least a portion of the inner catheter. The inner catheter may include at least three lumina extending from the proximal end to the distal end of the inner catheter, at least one infusion fenestration along the infusion segment, and a distal encapsulation balloon at the distal end. The outer sheath may include at least three lumina extending from the proximal end to the distal end of the outer sheath and a proximal encapsulation balloon at the distal end. The catheter system may further include an agitator for mechanical morcellation of the thrombus.

Abstract: An arteriovenous graft and methods of reducing the risk of graft thrombosis and extending patency of the arteriovenous graft are provided herein. The arteriovenous graft is operable for attaching to a vein at a venous anastomosis. In some aspects, the arteriovenous graft includes a plurality of grooves at a venous anastomosis end of the arteriovenous graft and the venous anastomoses may be arranged such that the arteriovenous graft and the vein meet at an angle of 30° or less.

Abstract: The disclosure provides for a device and method for treating aortoiliac occlusion disease with the placement of a fenestrated stent system at the aortic bifurcation. The fenestrated stent system includes a tapered fenestrated stent with a fenestration and a common iliac stent that is placed within the fenestration of the fenestrated stent.

Abstract: The disclosure provides for an adjustable catheter system with isovolumetric suction and restoration of fluid for the removal of a thrombus and a method of use thereof. The catheter system includes an inner catheter and an outer sheath surrounding at least a portion of the inner catheter. The inner catheter may include at least three lumina extending from the proximal end to the distal end of the inner catheter, at least one infusion fenestration along the infusion segment, and a distal encapsulation balloon at the distal end. The outer sheath may include at least three lumina extending from the proximal end to the distal end of the outer sheath and a proximal encapsulation balloon at the distal end. The catheter system may further include an agitator for mechanical morcellation of the thrombus.

Abstract: Devices, systems, and methods of facilitating airway management with reduced risk of release of droplets and aerosolized pathogens from the lungs of a patient are disclosed, including a bronchoscope adapter for an endotracheal tube, an endotracheal tube with integral bronchoscope adapter, an endotracheal intubation mask system, a laryngeal mask airway-specific mask system, and a quick-seal laryngeal mask airway-specific mask system.

Abstract: Among the various aspects of the present disclosure is the provision of a method of detection, treatment, and monitoring of cardiovascular disease or a foot wound by detection of a novel biomarker, Fatty Acid Synthase (FAS). Briefly, therefore, the present disclosure is directed to methods that allow for improved, noninvasive, and reliable diagnosis of these conditions, particularly in subjects suffering from Type 2 Diabetes (T2D).

Abstract: The disclosure provides for an adjustable catheter system with isovolumetric suction and restoration of fluid for the removal of a thrombus and a method of use thereof. The catheter system includes an inner catheter and an outer sheath surrounding at least a portion of the inner catheter. The inner catheter may include at least three lumina extending from the proximal end to the distal end of the inner catheter, at least one infusion fenestration along the infusion segment, and a distal encapsulation balloon at the distal end. The outer sheath may include at least three lumina extending from the proximal end to the distal end of the outer sheath and a proximal encapsulation balloon at the distal end. The catheter system may further include an agitator for mechanical morcellation of the thrombus.

Abstract: Among the various aspects of the present disclosure is the provision of a method of detection, treatment, and monitoring of cardiovascular disease or a foot wound by detection of a novel biomarker, Fatty Acid Synthase (FAS). Briefly, therefore, the present disclosure is directed to methods that allow for improved, noninvasive, and reliable diagnosis of these conditions, particularly in subjects suffering from Type 2 Diabetes (T2D).

Abstract: An arteriovenous graft and methods of reducing the risk of graft thrombosis and extending patency of the arteriovenous graft are provided herein. The arteriovenous graft is operable for attaching to a vein at a venous anastomosis. In some aspects, the arteriovenous graft includes a plurality of grooves at a venous anastomosis end of the arteriovenous graft and the venous anastomoses may be arranged such that the arteriovenous graft and the vein meet at an angle of 30° or less.

Abstract: The disclosure provides for a device and method for treating aortoiliac occlusion disease with the placement of a fenestrated stent system at the aortic bifurcation. The fenestrated stent system includes a tapered fenestrated stent with a fenestration and a common iliac stent that is placed within the fenestration of the fenestrated stent.

Abstract: Among the various aspects of the present disclosure is the provision of a method of detection, treatment, and monitoring of cardiovascular disease or a foot wound by detection of a novel biomarker, Fatty Acid Synthase (FAS).