Abstract: The present invention provides a system and methods for filtering fluid using filter papers, stationary paper, cloth sheets or any other porous material. In one embodiment, the present invention uses the lateral flow direction along the porous sheets, instead of conventional vertical flow direction, for the removal of bacteria and particle contamination in the range from nanometers to millimeters. The pore sizes in the filter media along the lateral direction are modulated by controlling the compression of the porous sheets, instead of conventionally designing filters with different pore sizes. The lateral flow fluid filter system is scalable simply by increasing the feed area, feed length, and the number of porous sheets. The invention presents a universal fluid filtration system for wide range of applications such as water purification, food processing, chemical industry, oil and gas industry, and biological applications.

Abstract: Disclosed is a multipurpose scanning microscopy probe comprising a probe holder, a cantilever connected to the probe holder, and a probe tip connected to the cantilever, wherein the probe tip is a three-dimensional geometry, and wherein the probe tip is a 3D printed part. In some embodiments the probe is made from SU8 epoxy-based resin. In some embodiments the probe is made from a combination of SU8 and nanomaterial such as carbon nanotubes. In some embodiments the probe includes cavities and voids. In some embodies the probe includes fluidic features and elements. Scanning microscopy probe methods are also disclosed.

Abstract: A system and method for cryopreservation of cells or spheroids of cells including obtaining a suspension of the isolated mammalian cells in a medium; applying the suspension to a fibrous substrate comprising a network of interconnected cellulosic fibers defining a plurality of pores therein and allowing the suspension to absorb into the fibrous substrate such that the isolated mammalian cells penetrate and settle to an interior of the fibrous substrate; and cooling the fibrous substrate to or below a temperature of ?80° C.

Abstract: The present invention provides microfluidic porous substrate-based devices for multiplexed biosensing. The devices are suitable for detecting viruses and bacteria, such as by way of detecting pathogenic genes and antibodies. The devices support reverse transcriptase loop-mediated isothermal amplification for rapid results within minutes. The devices also support vertical-lateral-vertical direction flow assays, such as in the form of a multi-layered adhesive bandage.

Abstract: A non-contact cell manipulation system comprises a supporting member, a micro-positioner, a probe holder having a proximal end and a distal end, the proximal end connected to the micro-positioner, a probe adapter removably connected to the distal end of the probe holder and a non-contact multiphysics probe fluidly and electrically connected to the probe adapter, wherein the probe includes at least one electrode, at least one aperture, and wherein the probe is configured to utilize electropermealization and electroheating in combination with hydrodynamic flow confinement to perform non-contact cell manipulation. A non-contact multiphysics probe and non-contact cell manipulation method are also disclosed.

Abstract: Disclosed is a multipurpose scanning microscopy probe comprising a probe holder, a cantilever connected to the probe holder, and a probe tip connected to the cantilever, wherein the probe tip is a three-dimensional geometry, and wherein the probe tip is a 3D printed part. In some embodiments the probe is made from SU8 epoxy-based resin. In some embodiments the probe is made from a combination of SU8 and nanomaterial such as carbon nanotubes. In some embodiments the probe includes cavities and voids. In some embodies the probe includes fluidic features and elements. Scanning microscopy probe methods are also disclosed.

Abstract: The present invention provides a system and methods for filtering fluid using filter papers, stationary paper, cloth sheets or any other porous material. In one embodiment, the present invention uses the lateral flow direction along the porous sheets, instead of conventional vertical flow direction, for the removal of bacteria and particle contamination in the range from nanometers to millimeters. The pore sizes in the filter media along the lateral direction are modulated by controlling the compression of the porous sheets, instead of conventionally designing filters with different pore sizes. The lateral flow fluid filter system is scalable simply by increasing the feed area, feed length, and the number of porous sheets. The invention presents a universal fluid filtration system for wide range of applications such as water purification, food processing, chemical industry, oil and gas industry, and biological applications.

Abstract: A system and method for cryopreservation of cells or spheroids of cells including obtaining a suspension of the isolated mammalian cells in a medium; applying the suspension to a fibrous substrate comprising a network of interconnected cellulosic fibers defining a plurality of pores therein and allowing the suspension to absorb into the fibrous substrate such that the isolated mammalian cells penetrate and settle to an interior of the fibrous substrate; and cooling the fibrous substrate to or below a temperature of ?80° C.