Patents by Inventor Mohammad AFSAR

Mohammad AFSAR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMAC MIMETICS FOR TREATMENT OF CANCER, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITION THEREOF
    Publication number: 20240083846
    Abstract: The present invention relates to novel SMAC mimetic peptidomimetics useful for the treatment of proliferative diseases including cancer in mammals The novel SMAC mimetics are prepared by incorporating (2S,5R)-5-(5-methylfuran-2-yl)pyrrolidine-2-carboxylic acid, a novel unnatural amino acid that imparts exclusively trans amide bond geometry favourable for target protein binding. Here, the novel SMAC mimetic molecule(s) not only show its efficacy in varied cancer types but also demonstrate in vitro and in vivo efficacy against therapy resistant cancer as a single agent. The novel SMAC mimetics disclosed in the present invention binds to BIR-2 and BIR-3 domains of the XIAP and exhibit high anti-proliferative activity against variety of mammalian cancer cell lines that include but not limited to chemotherapy and TRAIL resistant cell lines.
    Type: Application
    Filed: December 17, 2021
    Publication date: March 14, 2024
    Inventors: Wahajul HAQ, Rafat ALI, Akhilesh SINGH, Mushtaq Ahmad NENGROO, Roshan KATEKAR, Gajendra SINGH, Jayanti VAISHNAV, Mohammad AFSAR, Manohar SINGH, Srikanta Kumar RATH, Dipankar KOLEY, Durga Prasad MISHRA, Ravishankar RAMACHANDRAN, Ravi Sankar AMPAPATHI, Jiaur Rahaman GAYEN, Dipak DATTA
  • Polymer material for highly efficient organic thin-film solar cell, and organic thin-film solar cell using same
    Patent number: 9296864
    Abstract: The present invention relates to a novel polymeric material for a highly efficient organic thin-film solar cell with high hole mobility and power conversion efficiency. In the polymeric material, a compound containing an electron donating group represented by Formula 1 or 2 and a compound containing an electron accepting group represented by one of Formulae 3 to 8 are repeatedly introduced in an alternating manner.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: March 29, 2016
    Assignees: Pusan National University Industry-University Cooperation Foundation, UNIST ACADEMY-INDUSTRY RESEARCH CORPORATION
    Inventors: Han Young Woo, Jin Young Kim, Won Ho Lee, Thanh Luan Nguyen, Mohammad Afsar Uddin, Hyo Sung Choi, Seo Jin Ko
  • NOVEL POLYMER MATERIAL FOR HIGHTLY EFFICIENT ORGANIC THIN-FILM SOLAR CELL, AND ORGANIC THIN-FILM SOLAR CELL USING SAME
    Publication number: 20150361223
    Abstract: The present invention relates to a novel polymeric material for a highly efficient organic thin-film solar cell with high hole mobility and power conversion efficiency. In the polymeric material, a compound containing an electron donating group represented by Formula 1 or 2 and a compound containing an electron accepting group represented by one of Formulae 3 to 8 are repeatedly introduced in an alternating manner.
    Type: Application
    Filed: February 3, 2014
    Publication date: December 17, 2015
    Inventors: Han Young WOO, Jin Young KIM, Won Ho LEE, Thanh Luan NGUYEN, Mohammad Afsar UDDIN, Hyo Sung CHOI, Seo Jin KO