Patents by Inventor Mohammad Afshar
Mohammad Afshar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220205039Abstract: The application concerns means for determining the stage of hepatic tissue damage, in particular the hepatic fibrosis score of subjects infected with one or more hepatitis viruses. In particular, the means of the invention involve measuring the levels of expression of selected genes, said selected genes being: SPP1, and at least one gene from among A2M and VIM, and at least one gene from among IL8, CXCL10 and ENG, and optionally, at least one gene from among the list of the following sixteen genes: IL6ST, p14ARF, MMP9, ANGPT2, CXCL11, MMP2, MMP7, S100A4, TIMP1, CHI3L1, COL1A1, CXCL1, CXCL6, IHH, IRF9 and MMP1.Type: ApplicationFiled: December 28, 2021Publication date: June 30, 2022Inventors: BÉNÉDICTE WATELET, TARIK ASSELAH, IVAN BIECHE, ISABELLE CATHERINE BATXELLI, NATHALIE JULLIAN, MICHEL VIDAUD, PATRICK MARCELLIN, DANIEL LAUNE, MOHAMMAD AFSHAR, EVE LAURE MATHIEU
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Publication number: 20200056235Abstract: The application concerns means for determining the stage of hepatic tissue damage, in particular the hepatic fibrosis score of subjects infected with one or more hepatitis viruses. In particular, the means of the invention involve measuring the levels of expression of selected genes, said selected genes being: SPP1, and at least one gene from among A2M and VIM, and at least one gene from among IL8, CXCL10 and ENG, and optionally, at least one gene from among the list of the following sixteen genes: IL6ST, p14ARF, MMP9, ANGPT2, CXCL11, MMP2, MMP7, S100A4, TIMP1, CHI3L1, COL1A1, CXCL1, CXCL6, IHH, IRF9 and MMP1.Type: ApplicationFiled: August 28, 2019Publication date: February 20, 2020Inventors: BÉNÉDICTE WATELET, TARIK ASSELAH, IVAN BIECHE, ISABELLE CATHERINE BATXELLI, NATHALIE JULLIAN, MICHEL VIDAUD, PATRICK MARCELLIN, DANIEL LAUNE, MOHAMMAD AFSHAR, EVE LAURE MATHIEU
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Patent number: 10435744Abstract: The application concerns means for determining the stage of hepatic tissue damage, in particular the hepatic fibrosis score of subjects infected with one or more hepatitis viruses. In particular, the means of the invention involve measuring the levels of expression of selected genes, said selected genes being: SPP1, and at least one gene from among A2M and VIM, and at least one gene from among IL8, CXCL10 and ENG, and optionally, at least one gene from among the list of the following sixteen genes: IL6ST, p14ARF, MMP9, ANGPT2, CXCL11, MMP2, MMP7, S100A4, TIMP1, CHI3L1, COL1A1, CXCL1, CXCL6, IHH, IRF9 and MMP1.Type: GrantFiled: April 17, 2017Date of Patent: October 8, 2019Assignees: BIO-RAD EUROPE GMBH, ARIANA PHARMACEUTICALS, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Bénédicte Watelet, Tarik Asselah, Ivan Bieche, Isabelle Catherine Batxelli, Nathalie Jullian, Michel Vidaud, Patrick Marcellin, Daniel Laune, Mohammad Afshar, Eve Laure Mathieu
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Patent number: 9879320Abstract: The application concerns means for predicting whether a subject infected with one or more HCVs has a high probability of responding to an anti-HCV treatment which will comprise the administration of interferon and of ribavirin or whether, in contrast, that subject has a high probability of not responding to that anti-HCV treatment. The means of the invention in particular involve assaying the levels of expression of selected genes, said selected genes being: at least one gene from among MBL2, LGALS3BP and IL8, and at least one gene from among G1P2, CCL21 and CXCL10, and optionally, at least one gene from among AFP, CRP, CXCL11, CXCL6, CXCL9, FGF7, MDK, MMP2, SFN, TGFB2 and VEGFD.Type: GrantFiled: February 9, 2012Date of Patent: January 30, 2018Inventors: Ivan Bieche, Bénédicte Watelet, Tarik Asselah, Isabelle Catherine Batxelli, Eve Laure Mathieu, Nathalie Jullian, Michel Vidaud, Patrick Marcellin, Mohammad Afshar
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Publication number: 20170283871Abstract: The application concerns means for determining the stage of hepatic tissue damage, in particular the hepatic fibrosis score of subjects infected with one or more hepatitis viruses. In particular, the means of the invention involve measuring the levels of expression of selected genes, said selected genes being: SPP1, and at least one gene from among A2M and VIM, and at least one gene from among IL8, CXCL10 and ENG, and optionally, at least one gene from among the list of the following sixteen genes: IL6ST, p14ARF, MMP9, ANGPT2, CXCL11, MMP2, MMP7, S100A4, TIMP1, CHI3L1, COL1A1, CXCL1, CXCL6, IHH, IRF9 and MMP1.Type: ApplicationFiled: April 17, 2017Publication date: October 5, 2017Inventors: BÉNÉDICTE WATELET, TARIK ASSELAH, IVAN BIECHE, ISABELLE CATHERINE BATXELLI, NATHALIE JULLIAN, MICHEL VIDAUD, PATRICK MARCELLIN, DANIEL LAUNE, MOHAMMAD AFSHAR, EVE LAURE MATHIEU
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Patent number: 9624541Abstract: The application concerns means for determining the stage of hepatic tissue damage, in particular the hepatic fibrosis score of subjects infected with one or more hepatitis viruses. In particular, the means of the invention involve measuring the levels of expression of selected genes, said selected genes being: SPP1, and at least one gene from among A2M and VIM, and at least one gene from among IL8, CXCL10 and ENG, and optionally, at least one gene from among the list of the following sixteen genes: IL6ST, p14ARF, MMP9, ANGPT2, CXCL11, MMP2, MMP7, S100A4, TIMP1, CHI3L1, COL1A1, CXCL1, CXCL6, IHH, IRF9 and MMP1.Type: GrantFiled: February 9, 2012Date of Patent: April 18, 2017Assignees: BIO-RAD INNOVATIONS, ARIANA PHARMACEUTICALS, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Bénédicte Watelet, Tarik Asselah, Ivan Bieche, Isabelle Catherine Batxelli, Nathalie Jullian, Michel Vidaud, Patrick Marcellin, Daniel Laune, Mohammad Afshar, Eve Laure Mathieu
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Publication number: 20130323720Abstract: The application concerns means for determining the stage of hepatic tissue damage, in particular the hepatic fibrosis score of subjects infected with one or more hepatitis viruses. In particular, the means of the invention involve measuring the levels of expression of selected genes, said selected genes being: SPP1, and at least one gene from among A2M and VIM, and at least one gene from among IL8, CXCL10 and ENG, and optionally, at least one gene from among the list of the following sixteen genes: IL6ST, p14ARF, MMP9, ANGPT2, CXCL11, MMP2, MMP7, S100A4, TIMP1, CHI3L1, COL1A1, CXCL1, CXCL6, IHH, IRF9 and MMP1.Type: ApplicationFiled: February 9, 2012Publication date: December 5, 2013Applicant: BIO RAD INNOVATIONSInventors: Bénédicte Watelet, Tarik Asselah, Ivan Bieche, Isabelle Catherine Batxelli, Nathalie Jullian, Michel Vidaud, Patrick Marcellin, Daniel Laune, Mohammad Afshar, Eve Laure Mathieu
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Publication number: 20130316332Abstract: The application concerns means for predicting whether a subject infected with one or more HCVs has a high probability of responding to an anti-HCV treatment which will comprise the administration of interferon and of ribavirin or whether, in contrast, that subject has a high probability of not responding to that anti-HCV treatment. The means of the invention in particular involve assaying the levels of expression of selected genes, said selected genes being: at least one gene from among MBL2, LGALS3BP and IL8, and at least one gene from among G1P2, CCL21 and CXCL10, and optionally, at least one gene from among AFP, CRP, CXCL11, CXCL6, CXCL9, FGF7, MDK, MMP2, SFN, TGFB2 and VEGFD.Type: ApplicationFiled: February 9, 2012Publication date: November 28, 2013Applicants: BIO-RAD INNOVATIONS, ARIANA PHARMACEUTICALS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALEInventors: Ivan Bieche, Bénédicte Watelet, Tarik Asselah, Isabelle Catherine Batxelli, Eve Laure Mathieu, Nathalie Jullian, Michel Vidaud, Patrick Marcellin, Mohammad Afshar
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Publication number: 20020138204Abstract: A method for defining a binding site in a biological macromolecule based on a two-sphere grid and a method for determining the free energy of a ligand:RNA structure based on pseudo-energy values. These methods can be use in docking and also in high-throughput in silico screening of ligand libraries against an RNA structure of interest.Type: ApplicationFiled: October 24, 2001Publication date: September 26, 2002Inventors: Mohammad Afshar, Stephen Morley
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Publication number: 20020045168Abstract: A method for defining a binding site in a biological macromolecule based on a two-sphere grid and a method for determining the free energy of a ligand:RNA structure based on pseudo-energy values. These methods can be use in docking and also in high-throughput in silico screening of ligand libraries against an RNA structure of interest.Type: ApplicationFiled: December 22, 2000Publication date: April 18, 2002Inventors: Mohammad Afshar, Stephen Morley
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Publication number: 20020018988Abstract: A model structure of sub-domain IIId of the hepatitis C virus internal ribosome entry site has been elucidated. The invention provides an in silico method for identifying a compound that interacts with sub-domain IIId, comprising the steps of: (a) providing atomic co-ordinates of said sub-domain IIId in a storage medium on a Computer; and (b) using said computer to apply molecular modelling techniques to said co-ordinates. Suitable methods include de novo compound design, use of a pharmacophore, and automated docking algorithms.Type: ApplicationFiled: April 26, 2001Publication date: February 14, 2002Inventors: Roscoe Klinck, Stephen Walker, Mohammad Afshar, Adam Collier, Fareed Aboul-ela, Eric Westhof
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Patent number: 5251407Abstract: A hand-held grinding device 1, 50, 60 for sharpening the cutting edge 3 of a chisel 4 comprises a housing 5 in which a grinding wheel 6 is mounted and a handle member 7 defining a guide channel 20 for directing the cutting edge 3 to the wheel 6. The grinding wheel 6 is mounted on a shaft 10 with a free end 8 for mounting in the chuck 9 of a power tool 19. The guide channel 20 has a rear end entry 22 and an end exit 21 adjacent to the grinding surface of the wheel 6. The cutting edge 3 of a chisel 4 to be sharpened is urged against the grinding wheel 6 by spring biassing elements 25, 26 extending into the guide channel 20. A forward bridge 30 is provided above the exit 21 and a rearward bridge member 35 is provided above the end entry 22.Type: GrantFiled: February 12, 1992Date of Patent: October 12, 1993Assignee: Mayka Research and DevelopmentInventor: Mohammad Afshar
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Patent number: 4744178Abstract: A hand held grinding device for sharpening drill bits comprises a pair of bearing members which rotatably support a grinding wheel fast on a shaft. Portion of the shaft is engagable with the chuck of a drill. A guide plate with grooves for various size ranges of drill bits is hingedly connected to the bearing members by a plastics hinge. The grooves direct the drill bit to the grinding wheel at an angle of 59.degree.. By pivoting the guide plate relative to the bearing members, the trailing portion of the cutting edge of the drill bit is relieved.Type: GrantFiled: September 25, 1986Date of Patent: May 17, 1988Assignee: Institute for Industrial Research and StandardsInventor: Mohammad Afshar