Abstract: A new class of sensing elements made of a protein pore fused to a programmable antibody-mimetic binder. This modular design expands the utility of nanopore sensors to numerous proteins while preserving their architecture, specificity, and sensitivity. The sensing elements were validated with protein analytes that drastically vary in size, charge, and structural complexity. These analytes produce unique electrical signatures that depend on their identity and quantity and the binder-analyte assembly at the nanopore tip.

Abstract: The present invention relates to novel SMAC mimetic peptidomimetics useful for the treatment of proliferative diseases including cancer in mammals The novel SMAC mimetics are prepared by incorporating (2S,5R)-5-(5-methylfuran-2-yl)pyrrolidine-2-carboxylic acid, a novel unnatural amino acid that imparts exclusively trans amide bond geometry favourable for target protein binding. Here, the novel SMAC mimetic molecule(s) not only show its efficacy in varied cancer types but also demonstrate in vitro and in vivo efficacy against therapy resistant cancer as a single agent. The novel SMAC mimetics disclosed in the present invention binds to BIR-2 and BIR-3 domains of the XIAP and exhibit high anti-proliferative activity against variety of mammalian cancer cell lines that include but not limited to chemotherapy and TRAIL resistant cell lines.

Abstract: This disclosure provides systems, methods, and apparatus for a package delivery infrastructure. A server receives a request for a delivery transaction from a requesting device. The server, based on the request, determines a pick-up and drop-off location. The server determines an identity of a selected delivery entity based on request data and current locations of several delivery entities. The server transmits a delivery message to the selected delivery entity, the delivery message including at least one of a pick-up location, a drop-off location, and identity information of a user associated with the requesting device. The server transmits a confirmation message to the requesting device including identity information of the selected delivery entity.

Abstract: Examples described herein may include migration of data associated with a service to a container. An example method includes creating of a user virtual machine associated with a service and an associated virtual disk storing data associated with running the service, and creating a volume group and an associated storage container at a node of a computing system. The example method further includes storing a cloned version of the virtual disk into the storage container, and, in response to discovery of the cloned version of the virtual disk in the storage container, mounting the cloned version of the virtual disk on the volume group to provide access to clients running the service.

Abstract: The endodontic obturator for bioactive material delivery includes a shaft having opposed tip and shank ends, and a fluted portion located adjacent the tip end and having at least one flute spiraling along an axial length thereof. As a non-limiting example, the shaft may be formed from a nickel-titanium alloy coated with polytetrafluoroethylene. The forward portion is tapered toward the tip end, and the tip end is flat, with a fan-like cross-section, defining a plurality of radial lands. As a non-limiting example, three radial lands, each with a neutral rake angle, may be defined on the tip end.

Abstract: Examples described herein may include migration of data associated with a service to a container. An example method includes creating of a user virtual machine associated with a service and an associated virtual disk storing data associated with running the service, and creating a volume group and an associated storage container at a node of a computing system. The example method further includes storing a cloned version of the virtual disk into the storage container, and, in response to discovery of the cloned version of the virtual disk in the storage container, mounting the cloned version of the virtual disk on the volume group to provide access to clients running the service.

Abstract: A photonic sensor system includes: a photodetector; a signal processor coupled to the photodetector; and a sensor structure configured to provide fluid-response selectivity, spatially distribute light, and to receive light from a light source and convey light to the photodetector. The sensor structure includes a plurality of fluid sensitive interferometric nanostructure layers manufactured on a substrate; wherein the plurality of fluid sensitive interferometric nanostructure layers includes alternating high and low porosity layers.

Abstract: A sensor system for detection of an analyte in an industrial fluid in the presence of interferences which includes: a multivariable inductor-capacitor-resistor resonant transducer with multiple operationally independent outputs; a sensing material composition configured to provide different response patterns to an analyte in the fluid in the presence of interferences; and a signal processor that quantifies the analyte. Also, a sensor system for detection of an analyte that includes: a transducer with multiple operationally independent outputs; a sensing material compositions configured to provide different response patterns to an analyte in the industrial fluid in the presence of interferences; and a signal processor configured to quantify the analyte in the industrial fluid in the presence of interferences. An embodiment of the sensor system detects methane.

Abstract: A fluid sensor that includes fluid sensitive interferometric nanostructure layers configured into an open-air resonant structure. Another fluid sensor also includes a polarization sensitive photodetector configured to detect optical contributions of different components of a fluid to the structure. A photonic sensor system includes: a photodetector; a signal processor coupled to the photodetector; and a sensor structure configured to provide fluid-response selectivity, spatially distribute light, and to receive light from a light source and convey light to the photodetector. A method of selective measurement of components in fluid in a process area includes: exposing a sensing structure to the fluid; interrogating the sensing structure with light from outside the process area; measuring a change in optical properties of the sensing structure; correlating the measured change to a stored value; and providing quantitative values of levels of the components in the fluid.

Abstract: In accordance with embodiments, there are provided mechanisms and methods for SNMP based mobile device management. These mechanisms and methods for SNMP based mobile device management can enable embodiments to provide a unified and platform-independent MDM solution having the automated identification and handling of various network and/or mobile device conditions. The ability of embodiments to provide MDM in a platform-independent and automated manner can enable the delivery of reliable, error-free services to mobile device users.

Abstract: In accordance with embodiments, there are provided mechanisms and methods for SNMP based mobile device management. These mechanisms and methods for SNMP based mobile device management can enable embodiments to provide a unified and platform-independent MDM solution having the automated identification and handling of various network and/or mobile device conditions. The ability of embodiments to provide MDM in a platform-independent and automated manner can enable the delivery of reliable, error-free services to mobile device users.

Abstract: The present invention relates to a functional food composition, comprising: a thickening agent in an amount from 0.1 to 50% by weight, preferably 1 to 20% by weight; a raising and/or a bulk enhancing agent in an amount from 0.1 to 10% by weight, preferably 0.5 to 3% by weight; at least one edible oil in an amount from 0.1 to 20% by weight, preferably 2 to 10% by weight; at least one additive selected from the group consisting of flavor, surfactant, sweetener, preservative and coloring agent; and water in an amount from 20 to 90% by weight and the use of said functional food composition.

Abstract: The present specification discloses a processing architecture that has multiple levels of parallelism and is highly configurable, yet optimized for media processing. At the highest level, the architecture is structured to enable each processor, which is dedicated to a specific media processing function, to operate substantially in parallel. In addition to processor-level parallelism, each processing unit can operate on multiple words in parallel, rather than just a single word per clock cycle. Moreover, at the instruction level, the control data memory, data memory, and function specific dath paths can be controlled all within the same clock cycle.

Abstract: The present invention is a system on chip architecture having scalable, distributed processing and memory capabilities through a plurality of processing layers. In a preferred embodiment, a distributed processing layer processor comprises a plurality of processing layers, a processing layer controller, and a central direct memory access controller. The processing layer controller manages the scheduling of tasks and distribution of processing tasks to each processing layer. Within each processing layer, a plurality of pipelined processing units (PUs), specially designed for conducting a defined set of processing tasks, are in communication with a plurality of program memories and data memories. One application of the present invention is in a media gateway that is designed to enable the communication of media across circuit switched and packet switched networks.

Abstract: The present invention provides for an improved video compression and encoding that optimizes and enhances the overall speed and efficiency of processing video data. In one embodiment, the video codec transmits the output of an entropy decoder to a lossless compressor and memory before going through inverse discrete cosine transformation and motion compensation blocks.

Abstract: The photostability of organic material is enhanced by the incorporation of a plurality of particles which may for example have a diameter of 0.03 microns to 2.5 microns. The organic material may be a light absorbing material and may be photoluminescent or electroluminescent. Compositions in accordance with the invention incorporating an electroluminescent material of enhanced photostability may be used in an Organic Light Emitting Diode (OLED).

Abstract: A method and an apparatus for automatically measuring the thickness and the roughness of elongated articles, such as wooden boards. The device comprises a housing having an opening therethrough to receive at least a portion of a board to be measured. At least one contact probe is provided in the housing and is biased against at least one surface of the board to sense irregularities in the flatness of the surface along a measured length thereof. A measuring circuit is connected to the contact probe to provide a measurement signal representative of the sensed irregularities and variations in thickness. A distance measuring device is also provided in the housing to measure the distance of displacement of the board past the contact probe. An output display means indicates selected ones of the measurements obtained. A computing means accumulates measured values of the means, minimum and maximum thickness, for a group of boards and permits the extraction of such statistical information.

Abstract: The disclosure herein describes a trocar particularly intended for use in laparoscopic tubal cauterization and formed of: a puncturing sharp-pointed instrument, a cannula with a flange at one end thereof, a flexible insulating ring which is received in the flange recess bore, and a collar secured in the flange bore. The collar retains the ring in the flange while allowing it to flex as the puncturing instrument is introduced in the cannula or disassociated therefrom. The puncturing instrument, cannula and collar are made of inexpensive bio-compatible plastic materials while the ring is made of rubber; consequently, the trocar is disposable after use.