Abstract: A method and system are provided for operating an automatically guided container transport vehicle that can be automatically guided during forward driving and during rearward driving. The transport vehicle includes a towing vehicle and a trailer with a loading surface for at least one container. The transport vehicle has a vehicle control system for controlling a steering system and a travel drive of the transport vehicle in such a way that the transport vehicle follows a nominal route. The nominal route is automatically pre-defined taking into account a trajectory of the transport vehicle.

Abstract: Compounds, compositions and methods for modulating the expression of human GST-? using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2?-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.

Abstract: An arrangement of a gantry lifting device for handling containers, in particular ISO containers, having a sensor device for the navigation of the gantry lifting device and having a clearance profile which is formed such that the gantry lifting device can move across a container, and of a row of spaced-apart marking elements such that the gantry lifting device can be moved along the row of marking elements by means of raster navigation, where the row of marking elements can be read by the sensor device of the gantry lifting device. The sensor device, in an operating position, is arranged outside the clearance profile on the gantry lifting device so as, in the operating position, to read the row of marking elements for the navigation of the gantry lifting device, where the row of marking elements is arranged next to the clearance profile of the gantry lifting device.

Abstract: The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.

Abstract: Here described is a composition comprising a compound of formula I: wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleoyl group; R3 and R4 are independently selected from a group consisting of C1 to C6 alkyl, and C2 to C6 alkanol; X is selected from a group consisting of —CH2—, —S—, and —O— or absent; Y is selected from —(CH2)n, —S(CH2)n, —O(CH2)n—, thiophene, —SO2(CH2)n—, and ester; n=1-4; a=1-4; b=1-4; c=1-4; and Z? is a counterion.

Abstract: This invention provides compounds, compositions and methods for modulating the expression of human GST-? using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2?-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.

Abstract: Here described is a composition comprising a compound of formula I: wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleoyl group; R3 and R4 are independently selected from a group consisting of C1 to C6 alkyl, and C2 to C6 alkanol; X is selected from a group consisting of —CH2—, —S—, and —O— or absent; Y is selected from —(CH2)n, —S(CH2)n, —O(CH2)n—, thiophene, —SO2(CH2)n—, and ester; n=1-4; a=1-4; b=1-4; c=1-4; and Z? is a counterion.

Abstract: A system for determining the position of a transport vehicle that can be moved over a floor, in particular a heavy-load transport vehicle, comprising an antenna which can be attached to a lower face of the transport vehicle and a transponder which can be introduced into the floor at a specific location and which can be charged by means of a transmission field that can be generated by the antenna during a transmission interval and can be evaluated during a subsequent evaluation interval. The system is designed such that the evaluation interval is discontinued and a new transmission interval is started if a signal of the transponder cannot be detected during a detection interval within the evaluation interval.

Abstract: Here described is a composition comprising a compound of formula I: wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleoyl group; R3 and R4 are independently selected from a group consisting of C1 to C6 alkyl, and C2 to C6 alkanol; X is selected from a group consisting of —CH2—, —S—, and —O— or absent; Y is selected from —(CH2)n, —S(CH2)n, —O(CH2)n—, thiophene, —SO2(CH2)n—, and ester; n=1-4; a=1-4; b=1-4; c=1-4; and Z? is a counterion.

Abstract: Here described are compounds consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.

Abstract: A method and system are provided for operating an automatically guided container transport vehicle that can be automatically guided during forward driving and during rearward driving. The transport vehicle includes a towing vehicle and a trailer with a loading surface for at least one container. The transport vehicle has a vehicle control system for controlling a steering system and a travel drive of the transport vehicle in such a way that the transport vehicle follows a nominal route. The nominal route is automatically pre-defined taking into account a trajectory of the transport vehicle.

Abstract: The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.

Abstract: Here described is a method of delivery of a drug to a stellate cell using a composition comprising a compound of formula I: wherein R1 and R2 are independently selected from C10 to C18 alkyl, C12 to C18 alkenyl, and oleoyl; R3 and R4 are independently selected from C1 to C6 alkyl and C2 to C6 alkanol; X is selected from —CH2—, —S—, and —O—, or X is absent; Y is selected from —(CH2)n, —S(CH2)n—, —O(CH2)n—, -thiophene-, —SO2(CH2)n—, and ester; n?1-4; a?1-4; b?1-4; c?1-4; and Z? is a counterion.

Abstract: The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.

Abstract: An arrangement of a gantry lifting device for handling containers, in particular ISO containers, having a sensor device for the navigation of the gantry lifting device and having a clearance profile which is formed such that the gantry lifting device can move across a container, and of a row of spaced-apart marking elements such that the gantry lifting device can be moved along the row of marking elements by means of raster navigation, where the row of marking elements can be read by the sensor device of the gantry lifting device. The sensor device, in an operating position, is arranged outside the clearance profile on the gantry lifting device so as, in the operating position, to read the row of marking elements for the navigation of the gantry lifting device, where the row of marking elements is arranged next to the clearance profile of the gantry lifting device.

Abstract: A system for determining the position of a transport vehicle that can be moved over a floor, in particular a heavy-load transport vehicle, comprising an antenna which can be attached to a lower face of the transport vehicle and a transponder which can be introduced into the floor at a specific location and which can be charged by means of a transmission field that can be generated by the antenna during a transmission interval and can be evaluated during a subsequent evaluation interval. The system is designed such that the evaluation interval is discontinued and a new transmission interval is started if a signal of the transponder cannot be detected during a detection interval within the evaluation interval.

Abstract: What is described is a method for treating a fibrotic disease by administering a pharmaceutical composition comprising a drug carrier, which comprises a lipid and a retinoid, and a double-stranded nucleic acid molecule, which comprises an antisense sequence to mRNA encoding human hsp47.

Abstract: What is described is a pharmaceutical composition for treating a fibrotic disease comprising a drug carrier, which comprises a lipid and a retinoid, and a double-stranded nucleic acid molecule, which comprises an antisense sequence to mRNA encoding human hsp47.

Abstract: This invention provides compounds, compositions and methods for modulating the expression of human GST-? using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2?-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.

Abstract: This invention provides compounds, compositions and methods for modulating the expression of human GST-? using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2?-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.