Patents by Inventor Mohammad BOHLOOLY-YEGANEH

Mohammad BOHLOOLY-YEGANEH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene modification assays
    Patent number: 11254928
    Abstract: Provided herein, in some embodiments, are nucleic acid-based tools that may be used for high-throughput functional genomics studies as well as for the generation of knockout (gene inactivation or deletion) or knockin (gene activation or insertion) cell lines. Tools of the present disclosure include an “activatable reporter cassette,” a guide RNA construct and a nuclease that can be used together, for example, to modify and isolate targeted cells of interest.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: February 22, 2022
    Assignee: ASTRAZENECA AB
    Inventors: Marcello Maresca, Amir Taheri-Ghahfarokhi, Mohammad Bohlooly-Yeganeh, Lorenz M. Mayr
  • INDUCIBLE MODIFICATION OF A CELL GENOME
    Publication number: 20210230630
    Abstract: The present disclosure is directed, in some embodiments, to compositions and methods for inducible modification of a cell genome.
    Type: Application
    Filed: February 3, 2021
    Publication date: July 29, 2021
    Inventors: Marcello MARESCA, Mohammad BOHLOOLY-YEGANEH, Himjyot JAISWAL, Lorenz M. MAYR, Xiufeng XU
  • COMPOSITIONS AND METHODS FOR IMPROVING THE EFFICACY OF CAS9-BASED KNOCK-IN STRATEGIES
    Publication number: 20210180059
    Abstract: The present disclosure provides a non-naturally occurring CRISPR-Cas system comprising: a Cas9 effector protein capable of generating cohesive ends (stiCas9), and a guide polynucleotide that forms a complex with the stiCas9 and comprising a guide sequence, wherein the guide sequence hybridizes with a target sequence in a eukaryotic cell but does not hybridize to a sequence in a bacterial cell, and wherein the complex does not occur in nature. The present disclosure also provides a method of introducing a sequence of interest into a chromosome of a cell. Finally, the present disclosure provides for a method of modifying one or more nucleotides using seamless mutagenesis.
    Type: Application
    Filed: November 16, 2018
    Publication date: June 17, 2021
    Inventors: MARCELLO MARESCA, AMIR TAHERI-GHAHFAROKHI, FREDERIK KARLSSON, MOHAMMAD BOHLOOLY-YEGANEH, LORENZ MARTIN MAYR
  • Inducible modification of a cell genome
    Patent number: 10947559
    Abstract: The present disclosure is directed, in some embodiments, to compositions and methods for inducible modification of a cell genome.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: March 16, 2021
    Assignee: ASTRAZENECA AB
    Inventors: Marcello Maresca, Mohammad Bohlooly-Yeganeh, Himjyot Jaiswal, Lorenz M. Mayr, Xiufeng Xu
  • GENE MODIFICATION ASSAYS
    Publication number: 20190024074
    Abstract: Provided herein, in some embodiments, are nucleic acid-based tools that may be used for high-throughput functional genomics studies as well as for the generation of knockout (gene inactivation or deletion) or knockin (gene activation or insertion) cell lines. Tools of the present disclosure include an “activatable reporter cassette,” a guide RNA construct and a nuclease that can be used together, for example, to modify and isolate targeted cells of interest.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 24, 2019
    Inventors: Marcello MARESCA, Amir TAHERI-GHAHFAROKHI, Mohammad BOHLOOLY-YEGANEH, Lorenz M. MAYR
  • INDUCIBLE MODIFICATION OF A CELL GENOME
    Publication number: 20180305714
    Abstract: The present disclosure is directed, in some embodiments, to compositions and methods for inducible modification of a cell genome.
    Type: Application
    Filed: October 14, 2016
    Publication date: October 25, 2018
    Inventors: Marcello MARESCA, Mohammad BOHLOOLY-YEGANEH, Himjyot JAISWAL, Lorenz M. MAYR, Xiufeng XU