Abstract: A clinical evaluation system and method are disclosed that facilitate the use of features or parameters extracted from biophysical signals in a model or classifier (e.g., a machine-learned classifier) to estimate metrics associated with the physiological state of a patient, including for the presence or non-presence of elevated left ventricular end-diastolic pressure (elevated LVEDP), as an example indicator of a disease medical condition that could be assessed by using the system and method described herein.