Abstract: The present invention provides a method of treating a disease or disorder characterized by electro-mitochondrial desynchronization in a subject in need thereof, comprising confirming the disease or disorder is characterized by electro-mitochondrial desynchronization in the subject and administering an agent that modulates mitochondrial calcium concentration and/or increases mitochondrial calcium channel activity in a tissue of the disease or disorder in the subject. Multichambered cardiac organoids comprising cardiomyocytes and endothelial cells and at least two chambers beating in synchrony are provided. Further provided are methods of using the multichambered cardiac organoid, methods of producing a cardiac organoid. Systems for making measurements within cellular aggregates or tissues and the use of same for testing therapeutic agents is also provided.

Abstract: The technology disclosed herein concerns a process and system for producing a multi- sectional food product having an external shape and a plurality of internal sections.

Abstract: The present disclosure provides endoscopic retrograde cholangiopancreatography (ERCP) catheter systems having multiple ports and sensors configured to determine the location of the catheter's and/or guidewire's distal end as well as optional one or more magnetic bending aids, configured to aim a guidewire to the desired duct location. Further provided is a guidewire having a magnetic end and optional sensing elements. Also provided are methods of using the catheters and/or guidewires in ERCP procedures.