Patents by Inventor Mohammad Haj Dezfulian

Mohammad Haj Dezfulian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for identifying epitopes
    Patent number: 11834653
    Abstract: Described herein, in one aspect, are antigen presenting cells (APCs) comprising an exogenous nucleic acid encoding one or more candidate antigens, wherein the one or more candidate antigens are expressed and presented with MHC class I or MC class II molecules; a molecular reporter of Granzyme B (GzB) activity; and c) an exogenous inhibitor of caspase-activated deoxyribonuclease (CAD)-mediated DNA degradation, a CAD knockout, or a caspase knockout (e.g., caspase 3 knockout). Described herein, in another aspect, is a system for detection of recognized antigen presentation by an antigen presenting cell to a cytotoxic lymphocyte or NK cell.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: December 5, 2023
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Stephen Elledge, Tomasz Kula, Mohammad Haj Dezfulian
  • METHODS AND COMPOSITIONS FOR IDENTIFYING EPITOPES
    Publication number: 20200102553
    Abstract: Described herein, in one aspect, are antigen presenting cells (APCs) comprising an exogenous nucleic acid encoding one or more candidate antigens, wherein the one or more candidate antigens are expressed and presented with MHC class I or MC class II molecules; a molecular reporter of Granzyme B (GzB) activity; and c) an exogenous inhibitor of caspase-activated deoxyribonuclease (CAD)-mediated DNA degradation, a CAD knockout, or a caspase knockout (e.g., caspase 3 knockout). Described herein, in another aspect, is a system for detection of recognized antigen presentation by an antigen presenting cell to a cytotoxic lymphocyte or NK cell.
    Type: Application
    Filed: June 8, 2018
    Publication date: April 2, 2020
    Inventors: Stephen Elledge, Tomasz Kula, Mohammad Haj Dezfulian