Abstract: The embodiments herein provide a fuel anti-freeze system comprising a temperature sensor, an Engine Control Unit (ECU), a combustion rail pump and two electrical valves. The temperature sensor reports an atmospheric temperature of a fuel rail to the ECU. The ECU controls the combustion rail pump and the electrical valves to control a depletion of the fuel from the fuel rail to a fuel tank, when the atmosphere temperature in the fuel rail is below a threshold temperature. The system empties the fuel rail when the atmosphere temperature is below the threshold temperature, thereby preventing freezing and stiffing of the fuel in the fuel rail of an internal combustion engine. The first electrical valve transfers the fuel from the fuel rail to the fuel tank, and the second electrical valve transfers the fuel from the fuel rail to the fuel tank.

Abstract: The embodiments herein provide a fuel anti-freeze system comprising a temperature sensor, an Engine Control Unit (ECU), a combustion rail pump and two electrical valves. The temperature sensor reports an atmospheric temperature of a fuel rail to the ECU. The ECU controls the combustion rail pump and the electrical valves to control a depletion of the fuel from the fuel rail to a fuel tank, when the atmosphere temperature in the fuel rail is below a threshold temperature. The system empties the fuel rail when the atmosphere temperature is below the threshold temperature, thereby preventing freezing and stiffing of the fuel in the fuel rail of an internal combustion engine. The first electrical valve transfers the fuel from the fuel rail to the fuel tank, and the second electrical valve transfers the fuel from the fuel rail to the fuel tank.

Abstract: The present invention provides targeted delivery systems to deliver pharmaceuticals to irradiated tissue comprising a biomolecule carrier, a targeting moiety to cellular adhesion molecules and a pharmaceutical. The present invention also provides methods of selectively targeting endothelial tissue for delivery of a pharmaceutical thereto and of treating a pathophysiological state in an individual using the targeted delivery systems disclosed herein. Further provided is a method of optimizing an immunoliposome for specific targeting of a pharmaceutical encapsulated therein to irradiated tissue by selecting a liposome that has a greater rate of adhesion to the irradiated tissue than a rate of uptake by the reticuloendothelial system.