Patents by Inventor Mohammad Noshi

Mohammad Noshi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHESIS AND COMPOSITION OF AMINO ACID LINKING GROUPS CONJUGATED TO COMPOUNDS USED FOR THE TARGETED IMAGING OF TUMORS
    Publication number: 20210093737
    Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.
    Type: Application
    Filed: December 7, 2020
    Publication date: April 1, 2021
    Inventors: Sumith A. Kularatne, Sakkarapalayam M. Mahalingam, Philip S. Low, Mohammad Noshi
  • Cholecystokinin 2 receptor targeted NIR imaging and use thereof
    Patent number: 10786580
    Abstract: Compounds are described herein where CCK2R targeting ligands are attached to an imaging agent through a linker. The compounds can be used in the detection, diagnosis, imaging and treatment of cancer.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: September 29, 2020
    Assignee: On Target Laboratories, LLC
    Inventors: Sumith A. Kularatne, Pravin Gagare, Mohammad Noshi
  • CHOLECYSTOKININ 2 RECEPTOR TARGETED NIR IMAGING AND USE THEREOF
    Publication number: 20180071408
    Abstract: Compounds are described herein where CCK2R targeting ligands are attached to an imaging agent through a linker. The compounds can be used in the detection, diagnosis, imaging and treatment of cancer.
    Type: Application
    Filed: September 8, 2017
    Publication date: March 15, 2018
    Inventors: Sumith A. Kularatne, Pravin Gagare, Mohammad Noshi
  • Large-scale diastereoselective syntheses of cycloheptadienylsulfones and stereotetrads
    Publication number: 20170217996
    Abstract: The invention relates to processes for large-scale diastereoselective syntheses of cycloheptadienylsulfone and stereotetrads, key intermediates for the preparation of Aplyronine A.
    Type: Application
    Filed: April 4, 2017
    Publication date: August 3, 2017
    Applicant: Purdue Research Foundation
    Inventors: Philip L. Fuchs, Mohammad Noshi
  • Methods of manufacture of pteroyl-amino acid-fluorescent dyes
    Patent number: 9254341
    Abstract: The present invention discloses a process for preparing a compound having the formula Including Reacting a compound of the formula 1: with a compound of the formula: in the presence of a polar solvent and trifluoroacetic acid to provide a compound of the formula: or a racemic mixture thereof; and further reacting the compound of the formula: or a racemic mixture thereof; with sodium hydroxide and a compound of the formula: wherein R1 and R2 are as defined above.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: February 9, 2016
    Inventors: Sumith A. Kularatne, Pravin Gagare, Mohammad Noshi
  • Methods of Manufacture and Synthesis of Amino Acid Linking Groups Conjugated To Compounds Used For Targeted Imaging of Tumors
    Publication number: 20140275533
    Abstract: Methods of synthesis and compositions of use for compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof.
    Type: Application
    Filed: October 4, 2013
    Publication date: September 18, 2014
    Applicant: On Target Laboratories, LLC
    Inventors: Sumith A. Kularatne, Pravin Gagare, Mohammad Noshi