Patents by Inventor Mohammad Reza Ebrahimkhani

Mohammad Reza Ebrahimkhani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineering a heterogeneous tissue from pluripotent stem cells
    Patent number: 10435710
    Abstract: Aspects of the present disclosure are directed to methods and compositions for the production of heterogeneous tissue from human induced pluripotent stem (hiPS) cells.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: October 8, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Patrick Guye, Ron Weiss, Mohammad Reza Ebrahimkhani
  • MULTILAYER GENETIC SAFETY KILL CIRCUITS BASED ON SINGLE CAS9 PROTEIN AND MULTIPLE ENGINEERED GRNA IN MAMMALIAN CELLS
    Publication number: 20180251789
    Abstract: Aspects of the disclosure relate to synthetic regulatory systems composed of a multifunctional clustered regularly interspaced short palindromic repeat (CRISPR)-associated (Cas) nuclease and at least two distinct guide RNAs (gRNAs). The synthetic regulatory system modulates cleavage and transcription, including repression and activation, in a mammalian cell such as a human cell.
    Type: Application
    Filed: September 1, 2016
    Publication date: September 6, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Samira Kiani, Ron Weiss, Mohammad Reza Ebrahimkhani
  • ENGINEERING A HETEROGENEOUS TISSUE FROM PLURIPOTENT STEM CELLS
    Publication number: 20170306351
    Abstract: Aspects of the present disclosure are directed to methods and compositions for the production of heterogeneous tissue from human induced pluripotent stem (hiPS) cells.
    Type: Application
    Filed: May 9, 2017
    Publication date: October 26, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Patrick Guye, Ron Weiss, Mohammad Reza Ebrahimkhani
  • Engineering a heterogeneous tissue from pluripotent stem cells
    Patent number: 9677085
    Abstract: Aspects of the present disclosure are directed to methods and compositions for the production of heterogeneous tissue from human induced pluripotent stem (hiPS) cells.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: June 13, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Patrick Guye, Ron Weiss, Mohammad Reza Ebrahimkhani
  • GENERATION OF LAYERED TRANSCRIPTIONAL CIRCUITRY USING CRISPR SYSTEMS
    Publication number: 20160326546
    Abstract: Provided herein, in some embodiments, are modular transcriptional architectures and methods for regulated expression of guide RNAs in cells, such as human cells, which are based on Clustered Regularly Interspaced Palindromic Repeats (CRISPR) systems.
    Type: Application
    Filed: May 4, 2016
    Publication date: November 10, 2016
    Applicants: Massachusetts Institute of Technology, Raytheon BBN Technologies, Corp.
    Inventors: Samira Kiani, Ron Weiss, Jacob S. Beal, Mohammad Reza Ebrahimkhani, Zhen Xie, Yinqing Li