Abstract: An apparatus for analyzing a payload being transported in a load carrying container of a vehicle is disclosed. The apparatus includes a camera disposed to successively capture images of vehicles traversing a field of view of the camera. The apparatus also includes at least one processor in communication with the camera, the at least one processor being operably configured to select at least one image from the successively captured images in response to a likelihood of a vehicle and load carrying container being within the field of view in the at least one image, and image data associated with the least one image meeting a suitability criterion for further processing. The further processing includes causing the at least one processor to process the selected image to identify a payload region of interest within the image and to generate a payload analysis within the identified payload region of interest based the image data associated with the least one image.

Abstract: A computer processor implemented method and system for monitoring a condition associated with operating heavy equipment is disclosed. The method involves receiving a plurality of images at an interface of an embedded processor disposed on the heavy equipment, the images providing a view of at least an operating implement of the heavy equipment. The method also involves processing each of the plurality of images using a first neural network implemented on the embedded processor, the first neural network having been previously trained to identify regions of interest within the image. Each region of interest has an associated designation as at least one of a critical region suitable for extraction of critical operating condition information required for operation of the heavy equipment, and a non-critical region suitable for extraction of non-critical operating condition information associated with the operation of the heavy equipment.

Abstract: Spectral imaging systems are used to gather spectral image data on earthen material moving within an earthen material processing system, such as a mineral processing system or cement plant. Machine learning models such as 3D convolutional neural networks may be utilized to process the spectral image data to determine or classify one or more characteristics of the earthen material, such as ore grade, mineral alteration(s), moisture content, lithology and/or mineralogy. Such earthen material characteristics, or classifications thereof, may then be utilized to automatically control one or more operational characteristics of the earthen material processing system, such as rotational speed of milling equipment or flow rates of water or chemicals added to milling equipment or mineral concentration systems.

Abstract: The invention relates to a transdermal therapeutic system for the controlled release of water-soluble pharmaceutical active ingredients from an aqueous phase, comprising an occlusive back layer, a central device facing the skin for releasing the agent, an adhesive layer concentrically surrounding the dispensing device and a removable protective film. Said device is made from a stationary solid phase and a liquid phase containing the active ingredient in aqueous solution, the solid phase being formed from a solid with a fleecy or spongy structure.

Abstract: An apparatus for analyzing a payload being transported in a load carrying container of a vehicle is disclosed. The apparatus includes a camera disposed to successively capture images of vehicles traversing a field of view of the camera. The apparatus also includes at least one processor in communication with the camera, the at least one processor being operably configured to select at least one image from the successively captured images in response to a likelihood of a vehicle and load carrying container being within the field of view in the at least one image, and image data associated with the least one image meeting a suitability criterion for further processing. The further processing includes causing the at least one processor to process the selected image to identify a payload region of interest within the image and to generate a payload analysis within the identified payload region of interest based the image data associated with the least one image.

Abstract: The invention relates to a transdermal therapeutic system (TTS) for delivering pharmaceutical active ingredients. The TTS includes a cover layer and at least one active-ingredient-containing carrier material. At least one retaining element is located between the active-ingredient-containing carrier material and the cover layer, with the retaining element fixing the active-ingredient-containing carrier material onto the cover layer. The invention further relates to a method for fastening an active-ingredient-containing carrier material to a cover layer of a TTS in the presence of hook-and-loop strip segments and the use of a hook-and-loop strip in transdermal or iontophoretic administration of pharmaceutical or therapeutic active ingredients to patients.

Abstract: The invention relates to film-like forms of administration for the transmucosal delivery of antidiabetic peptides via the oral mucosa and to processes for the production thereof. Antidiabetic peptides refers to peptides which are an active compound for the treatment of diabetes mellitus, and includes insulins, insulin analogs, incretins and incretin mimetics.

Abstract: A computer processor implemented method and system for monitoring a condition associated with operating heavy equipment is disclosed. The method involves receiving a plurality of images at an interface of an embedded processor disposed on the heavy equipment, the images providing a view of at least an operating implement of the heavy equipment. The method also involves processing each of the plurality of images using a first neural network implemented on the embedded processor, the first neural network having been previously trained to identify regions of interest within the image. Each region of interest has an associated designation as at least one of a critical region suitable for extraction of critical operating condition information required for operation of the heavy equipment, and a non-critical region suitable for extraction of non-critical operating condition information associated with the operation of the heavy equipment.

Abstract: The invention relates to a composition for transdermal delivery, particularly iontophoretic transdermal delivery, of at least one cationic active agent or a salt thereof. The composition includes at least one cationic active agent or a salt thereof, at least one polyamine or/and polyamine salt, water or an aqueous solvent mixture, and optionally one or more additives. The invention further relates to the use of such composition as a component of a transdermal patch or of an iontophoretic transdermal patch, as well as to the use of such composition in a method for transdermally and/or iontophoretically administering cationic active agents. The invention further includes methods for determining the in vitro skin permeation properties of an active-agent-containing iontophoretic composition.

Abstract: A composition for transdermal delivery, particularly iontophoretic transdermal delivery, having at least one cationic active agent or a salt thereof. The composition comprises at least one cationic active agent or a salt thereof, at least one polyamine and/or polyamine salt, water or an aqueous solvent mixture, and optionally one or more additives. Use of the composition as a component of a transdermal patch or of an iontophoretic transdermal patch is also provided, as well as the use of the composition in a method for transdermally or iontophoretically administering cationic active agents. A method for determining the in vitro skin permeation properties of an active agent-containing iontophoretic composition is also provided.

Abstract: A method and apparatus for processing an image of fragmented material to identify fragmented material portions within the image is disclosed. The method involves receiving pixel data associated with an input plurality of pixels representing the image of the fragmented material. The method also involves processing the pixel data using a convolutional neural network, the convolutional neural network having a plurality of layers and producing a pixel classification output indicating whether pixels in the input plurality of pixels are located at one of an edge of a fragmented material portion, inwardly from the edge, and at interstices between fragmented material portions. The convolutional neural network includes at least one convolution layer configured to produce a convolution of the input plurality of pixels, the convolutional neural network having been previously trained using a plurality of training images including previously identified fragmented material portions.

Abstract: The invention relates to a composition for transdermal delivery, particularly iontophoretic transdermal delivery, of at least one cationic active agent or a salt thereof. The composition includes at least one cationic active agent or a salt thereof, at least one polyamine or/and polyamine salt, water or an aqueous solvent mixture, and optionally one or more additives. The invention further relates to the use of such composition as a component of a transdermal patch or of an iontophoretic transdermal patch, as well as to the use of such composition in a method for transdermally and/or iontophoretically administering cationic active agents. The invention further includes methods for determining the in vitro skin permeation properties of an active-agent-containing iontophoretic composition.

Abstract: The present invention relates to a transdermal therapeutic system, preferably a transdermal patch, having an active ingredient-containing matrix formed substantially of a water-insoluble base material, such as rubber and synthetic polymers, into which is incorporated water-soluble and/or water-swellable inclusion bodies, e.g. inclusion bodies formed from polyvinyl alcohol or polyethylene glycol, that further include micronized or nanoscale active ingredient particles.

Abstract: The invention relates to a transdermal therapeutic system (TTS) for delivering pharmaceutical active ingredients. The TTS includes a cover layer and at least one active-ingredient-containing carrier material. At least one retaining element is located between the active-ingredient-containing carrier material and the cover layer, with the retaining element fixing the active-ingredient-containing carrier material onto the cover layer. The invention further relates to a method for fastening an active-ingredient-containing carrier material to a cover layer of a TTS in the presence of hook-and-loop strip segments and the use of a hook-and-loop strip in transdermal or iontophoretic administration of pharmaceutical or therapeutic active ingredients to patients.

Abstract: The invention relates to a transdermal therapeutic system (TTS) for delivering pharmaceutical active ingredients. The TTS includes a cover layer and at least one active-ingredient-containing carrier material. At least one retaining element is located between the active-ingredient-containing carrier material and the cover layer, with the retaining element fixing the active-ingredient-containing carrier material onto the cover layer. The invention further relates to a method for fastening an active-ingredient-containing carrier material to a cover layer of a TTS in the presence of hook-and-loop strip segments and the use of a hook-and-loop strip in transdermal or iontophoretic administration of pharmaceutical or therapeutic active ingredients to patients.

Abstract: The present invention relates to a transdermal therapeutic system, preferably a transdermal patch, having an active ingredient-containing matrix formed substantially of a water-insoluble base material, such as rubber and synthetic polymers, into which is incorporated water-soluble and/or water-swellable inclusion bodies, e.g. inclusion bodies formed from polyvinyl alcohol or polyethylene glycol, that further include micronized or nanoscale active ingredient particles.

Abstract: A method and apparatus for locating and/or determining the condition of a wear part in an image of an operating implement associated with heavy equipment is disclosed. The method involves capturing at least one image of the operating implement during operation of the heavy equipment, the image including a plurality of pixels each having an intensity value. The method also involves selecting successive pixel subsets within the plurality of pixels, and processing each pixel subset to determine whether pixel intensity values in the pixel subset meet a matching criterion indicating a likelihood that the pixel subset corresponds to the wear part. The matching criterion is based on processing a labeled set of training images during a training exercise prior to capturing the at least one image of the operating implement.

Abstract: The invention relates to a transdermal therapeutic system, preferably a transdermal patch, having an active ingredient-containing matrix formed substantially of a water-insoluble base material, such as rubber and synthetic polymers, into which is incorporated water-soluble and/or water-swellable inclusion bodies, e.g. inclusion bodies formed from polyvinyl alcohol or polyethylene glycol, that further include micronized or nanoscale active ingredient particles.

Abstract: The invention relates to film-like forms of administration for the transmucosal delivery of antidiabetic peptides via the oral mucosa and to processes for the production thereof Antidiabetic peptides refers to peptides which are an active compound for the treatment of diabetes mellitus, and includes insulins, insulin analogs, incretins and incretin mimetics.

Abstract: A method and apparatus for processing an image of fragmented material to identify fragmented material portions within the image is disclosed. The method involves receiving pixel data associated with an input plurality of pixels representing the image of the fragmented material. The method also involves processing the pixel data using a convolutional neural network, the convolutional neural network having a plurality of layers and producing a pixel classification output indicating whether pixels in the input plurality of pixels are located at one of an edge of a fragmented material portion, inwardly from the edge, and at interstices between fragmented material portions. The convolutional neural network includes at least one convolution layer configured to produce a convolution of the input plurality of pixels, the convolutional neural network having been previously trained using a plurality of training images including previously identified fragmented material portions.