Abstract: The use of brain signals in controlling wheelchairs is a promising solution for many disabled individuals, specifically those who are suffering from motor neuron disease affecting the proper functioning of their motor units. Almost two decades since the first work, the applicability of EEG-driven wheelchairs is still limited to laboratory environments. In this work, a systematic review study has been conducted to identify the state-of-the-art and the different models adopted in the literature. Furthermore, a strong emphasis is devoted to introducing the challenges impeding a broad use of the technology as well as the latest research trends in each of those areas.