Patents by Inventor Mohammed A. HANIF
Mohammed A. HANIF has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240158502Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.Type: ApplicationFiled: November 1, 2023Publication date: May 16, 2024Inventors: Richard Charles Alfred SAINSON, Stephen John ARKINSTALL, Jamie Iain CAMPBELL, Mohammed Hanif ALI, E-Chiang LEE, Matthew John MCCOURT, Volker GERMASCHEWSKI, Ian KIRBY, Miha KOSMAC, Nahida PARVEEN, Robert ROWLANDS, Gwenoline BORHIS
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Patent number: 11858996Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.Type: GrantFiled: August 9, 2017Date of Patent: January 2, 2024Assignee: KYMAB LIMITEDInventors: Richard Charles Alfred Sainson, Stephen John Arkinstall, Jamie Iain Campbell, Mohammed Hanif Ali, E-Chiang Lee, Matthew John McCourt, Volker Germaschewski, Ian Kirby, Miha Kosmac, Nahida Parveen, Robert Rowlands, Gwenoline Borhis
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Publication number: 20230312720Abstract: Multispecific antibody having a binding site for ICOS and a binding site for a second antigen, e.g., an immune checkpoint molecule such as PD-L1. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours.Type: ApplicationFiled: September 1, 2022Publication date: October 5, 2023Inventors: Jamie CAMPBELL, Nikole SANDY, Cassandra VAN KRINKS, Ian KIRBY, Stephen John ARKINSTALL, Volker GERMASCHEWSKI, Miha KOSMAC, Thomas GALLAGHER, Cecilia DEANTONIO, Stephen Douglas GILLIES, Matthew John MCCOURT, Richard Charles Alfred SAINSON, Mohammed Hanif ALI, E-Chiang LEE
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Publication number: 20230192859Abstract: Multispecific antibody having a binding site for ICOS and a binding site for a second antigen, e.g., an immune checkpoint molecule such as PD-L1. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours.Type: ApplicationFiled: June 20, 2017Publication date: June 22, 2023Inventors: Jamie CAMPBELL, Nikole SANDY, Cassandra VAN KRINKS, Stephen John ARKINSTALL, Volker GERMASCHEWSKI, Ian KIRBY, Miha KOSMAC, Thomas GALLAGHER, Cecilia DEANTONIO, Stephen Douglas GILLIES, Matthew John MCCOURT, Richard Charles Alfred SAINSON, Mohammed Hanif ALI, E-Chiang LEE
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Publication number: 20230192847Abstract: The present invention relates to antibodies specific for one or more antigens, bispecific antibodies containing one or more domains with specificity to the target(s), and to immunocytokines. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.Type: ApplicationFiled: July 15, 2022Publication date: June 22, 2023Inventors: Joana de Abreu CARVALHO, Rachael Jane KIMBER, Jamie Ian CAMPBELL, Nikole SANDY, Cassandra VAN KRINKS, Stephen John ARKINSTALL, Volker GERMASCHEWSKI, Ian KIRBY, Miha KOSMAC, Thomas GALLAGHER, Matthew John MCCOURT, Richard Charles Alfred SAINSON, Mohammed Hanif ALI, E-Chiang LEE, Stephen Douglas GILLIES
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Publication number: 20220403029Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.Type: ApplicationFiled: April 22, 2022Publication date: December 22, 2022Inventors: Richard Charles Alfred SAINSON, Stephen John ARKINSTALL, Jamie Iain CAMPBELL, Mohammed Hanif ALI, E-Chiang LEE, Matthew John MCCOURT, Nikole SANDY, Cassandra VAN KRINKS, Volker GERMASCHEWSKI, Ian KIRBY, Miha KOSMAC, Thomas GALLAGHER, Cecilia DEANTONIO, Stephen Douglas GILLIES
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Publication number: 20220380467Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.Type: ApplicationFiled: April 22, 2022Publication date: December 1, 2022Inventors: Richard Charles Alfred SAINSON, Stephen John ARKINSTALL, Jamie Iain CAMPBELL, Mohammed Hanif ALI, E-Chiang LEE, Matthew John MCCOURT, Nikole SANDY, Cassandra VAN KRINKS, Volker GERMASCHEWSKI, Ian KIRBY, Miha KOSMAC, Thomas GALLAGHER, Cecilia DEANTONIO, Stephen Douglas GILLIES
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Patent number: 11440960Abstract: The present invention relates to antibodies specific for one or more antigens, bispecific antibodies containing one or more domains with specificity to the target(s), and to immunocytokines. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.Type: GrantFiled: June 20, 2018Date of Patent: September 13, 2022Assignee: KYMAB LIMITEDInventors: Joana de Abreu Carvalho, Rachael Jane Kimber, Jamie Ian Campbell, Nikole Sandy, Cassandra Van Krinks, Stephen John Arkinstall, Volker Germaschewski, Ian Kirby, Miha Kosmac, Thomas Gallagher, Matthew John McCourt, Richard Charles Alfred Sainson, Mohammed Hanif Ali, E-Chiang Lee, Stephen Douglas Gillies
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Publication number: 20200190191Abstract: Multispecific antibody having a binding site for ICOS and a binding site for a second antigen, e.g., an immune checkpoint molecule such as PD-L1. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours.Type: ApplicationFiled: December 19, 2017Publication date: June 18, 2020Inventors: Jamie Iain CAMPBELL, Nikole SANDY, Cassandra VAN KRINKS, Stephen John ARKINSTALL, Volker GERMASCHEWSKI, Ian KIRBY, Miha KOSMAC, Thomas GALLAGHER, Cecilia DEANTONIO, Stephen Douglas GILLIES, Matthew John MCCOURT, Richard Charles Alfred SAINSON, Mohammed Hanif ALI, E-Chiang LEE
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Publication number: 20200131267Abstract: The present invention relates to antibodies specific for one or more antigens, bispecific antibodies containing one or more domains with specificity to the target(s), and to immunocytokines. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.Type: ApplicationFiled: June 20, 2018Publication date: April 30, 2020Inventors: Joana de Abreu CARVALHO, Rachael Jane KIMBER, Jamie Ian CAMPBELL, Nikole SANDY, Cassandra VAN KRINKS, Stephen John ARKINSTALL, Volker GERMASCHEWSKI, Ian KIRBY, Miha KOSMAC, Thomas GALLAGHER, Matthew John MCCOURT, Richard Charles Alfred SAINSON, Mohammed Hanif ALI, E-Chiang LEE, Stephen Douglas GILLIES
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Patent number: 10472982Abstract: A variable geometry turbine assembly comprising an inlet passageway, extending radially inwards towards a turbine wheel, defined between a surface of a movable wall member and a facing wall and an actuation mechanism arranged to move the movable wall member axially and comprising a cam member provided with at least one formation and a carrier member axially coupled to at least one co-operating formation, wherein one of the at least one formation and the at least one co-operating formation is a radially extending formation, the at least one formation or the at least one co-operating formation extending in both the circumferential direction and the axial direction such that as the cam member is rotated relative to the carrier member, the at least one formation and the at least one co-operating formation engage such the movable wall member is moved in the axial direction.Type: GrantFiled: May 7, 2015Date of Patent: November 12, 2019Assignee: Cummins Ltd.Inventors: Mohammed Hanif Khan, David Camus, Frederick Carter, David Andrew Luck, Owen Wallbank, Robert L. Holroyd
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Publication number: 20190330345Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.Type: ApplicationFiled: August 9, 2017Publication date: October 31, 2019Inventors: Richard Charles Alfred SAINSON, Stephen John ARKINSTALL, Jamie Iain CAMPBELL, Mohammed Hanif ALI, E-Chiang LEE, Matthew John MCCOURT, Nikole SANDY, Cassandra VAN KRINKS, Volker GERMASCHEWSKI, Ian KIRBY, Miha KOSMAC, Thomas GALLAGHER, Cecilia DEANTONIO, Stephen Douglas GILLIES
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Publication number: 20190202917Abstract: Multispecific antibody having a binding site for ICOS and a binding site for a second antigen, e.g., an immune checkpoint molecule such as PD-L1. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours.Type: ApplicationFiled: June 20, 2017Publication date: July 4, 2019Inventors: Jamie CAMPBELL, Nikole SANDY, Cassandra VAN KRINKS, Stephen John ARKINSTALL, Volker GERMASCHEWSKI, Ian KIRBY, Miha KOSMAC, Thomas GALLAGHER, Cecilia DEANTONIO, Stephen Douglas GILLIES, Matthew John MCCOURT, Richard Charles Alfred SAINSON, Mohammed Hanif ALI, E-Chiang LEE
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Patent number: 9957323Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.Type: GrantFiled: September 7, 2017Date of Patent: May 1, 2018Assignee: Kymab LimitedInventors: Richard Charles Alfred Sainson, Stephen John Arkinstall, Jamie Iain Campbell, Mohammed Hanif Ali, E-Chiang Lee, Matthew John McCourt, Nikole Sandy, Cassandra Van Krinks, Volker Germaschewski, Ian Kirby, Miha Kosmac, Thomas Gallagher, Cecilia Deantonio, Stephen D. Gillies
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Publication number: 20180066058Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.Type: ApplicationFiled: September 7, 2017Publication date: March 8, 2018Inventors: Richard Charles Alfred SAINSON, Stephen John ARKINSTALL, Jamie Iain CAMPBELL, Mohammed Hanif ALI, E-Chiang LEE, Matthew John MCCOURT, Nikole SANDY, Cassandra VAN KRINKS, Volker GERMASCHEWSKI, Ian KIRBY, Miha KOSMAC, Thomas GALLAGHER, Cecilia DEANTONIO, Stephen D. GILLIES
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Publication number: 20170067359Abstract: A variable geometry turbine assembly comprising an inlet passageway, extending radially inwards towards a turbine wheel, defined between a surface of a movable wall member and a facing wall and an actuation mechanism arranged to move the movable wall member axially and comprising a cam member provided with at least one formation and a carrier member axially coupled to at least one co-operating formation, wherein one of the at least one formation and the at least one co-operating formation is a radially extending formation, the at least one formation or the at least one co-operating formation extending in both the circumferential direction and the axial direction such that as the cam member is rotated relative to the carrier member, the at least one formation and the at least one co-operating formation engage such the movable wall member is moved in the axial direction.Type: ApplicationFiled: May 7, 2015Publication date: March 9, 2017Inventors: Mohammed Hanif Khan, David Camus, Frederick Carter, David Andrew Luck, Owen Wallbank, Robert L. Holroyd
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Patent number: 8353158Abstract: A turbocharger bearing housing defines a bore in which the turbocharger shaft is mounted for rotation in journal bearings. Lubricating oil is delivered to the journal bearings and a residue is retained in reservoirs in which the journal bearings are located. Two fluid retaining members are disposed around the shaft, each forming a wall of the reservoir and being sealed to the bearing housing. The lubricating fluid reservoir is provided between the fluid retaining members to a depth that at least partially immerses the journal bearings even when the oil supply is interrupted. This ensures that there is sufficient oil to lubricate the bearings at engine start-up, thereby reducing the risk of wear.Type: GrantFiled: February 1, 2010Date of Patent: January 15, 2013Assignee: Cummins Turbo Technologies LimitedInventors: Matthew J Purdey, Mohammed Hanif Khan
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Publication number: 20120132300Abstract: A fail-safe fluid, particularly, water distribution apparatus for use within residential, commercial and industrial buildings comprising (i) a conduit through which fluid is distributed; (ii) a fluid flow time-sensitive sensor cooperative with the conduit to operably detect fluid flow within the conduit over desired periods of time; and (iii) a fluid control valve to control the flow of the fluid within the conduit cooperative with the sensor.Type: ApplicationFiled: November 26, 2010Publication date: May 31, 2012Inventor: Mohammed A. HANIF
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Publication number: 20100132358Abstract: A turbocharger bearing housing defines a bore in which the turbocharger shaft is mounted for rotation in journal bearings. Lubricating oil is delivered to the journal bearings and a residue is retained in reservoirs in which the journal bearings are located. Two fluid retaining members are disposed around the shaft, each forming a wall of the reservoir and being sealed to the bearing housing. The lubricating fluid reservoir is provided between the fluid retaining members to a depth that at least partially immerses the journal bearings even when the oil supply is interrupted. This ensures that there is sufficient oil to lubricate the bearings at engine start-up, thereby reducing the risk of wear.Type: ApplicationFiled: February 1, 2010Publication date: June 3, 2010Inventors: Matthew J. Purdey, Mohammed Hanif Khan