Patents by Inventor Mohammed Elias

Mohammed Elias has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant botulinum neurotoxin serotype A polypeptide and uses thereof
    Patent number: 8445650
    Abstract: Modified polypeptides based on the botulinum neurotoxin A heavy chain containing the double mutation Trp-Tyr->Leu-Ser in the ganglioside binding motif Ser-X-Trp-Tyr do not bind polysialogangliosides and nerve endings. The polypeptides are useful in the preparation of nontoxic vaccines against the effects of C. botulinum infection. The modified polypeptides are also useful as vehicles for the transepithelial delivery of diagnostic and therapeutic entities, through formation of conjugates between the polypeptides and the diagnostic or therapeutic entities.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: May 21, 2013
    Assignee: Thomas Jefferson University
    Inventors: Lance L. Simpson, Mohammed Elias
  • MUTANT BOTULINUM NEUROTOXIN SEROTYPE A POLYPEPTIDE AND USES THEREOF
    Publication number: 20100247560
    Abstract: Modified polypeptides based on the botulinum neurotoxin A heavy chain containing the double mutation Trp-Tyr->Leu-Ser in the ganglioside binding motif Ser-X-Trp-Tyr do not bind polysialogangliosides and nerve endings. The polypeptides are useful in the preparation of nontoxic vaccines against the effects of C. botulinum infection. The modified polypeptides are also useful as vehicles for the transepithelial delivery of diagnostic and therapeutic entities, through formation of conjugates between the polypeptides and the diagnostic or therapeutic entities.
    Type: Application
    Filed: September 25, 2008
    Publication date: September 30, 2010
    Applicant: THOMAS JEFFERSON UNIVERSITY
    Inventors: Lance L. Simpson, Mohammed Elias