Patents by Inventor Mohammed Milhem

Mohammed Milhem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TUMOR IMMUNOTHERAPY
    Publication number: 20210030783
    Abstract: Provided are compositions and methods for treating cancer using administration of certain volumes of CpG oligonucleotides (CpG ODN) and, optionally, administration of a checkpoint inhibitor such as an anti-PD-1 antibody, an anti-PD-L1 antibody, and/or an anti-CTLA-4 antibody. In preferred embodiments, the CpG ODN are selected based on their propensity to induce high amounts of interferon alpha (IFN-a) and T-cell activation relative to interleukin-10 (IL-10) and B-cell activation. In certain embodiments, the methods further include pretreatment with radiotherapy, to potentiate the combination immunotherapy.
    Type: Application
    Filed: February 12, 2019
    Publication date: February 4, 2021
    Inventors: Arthur Krieg, Aaron Morris, David Mauro, George Weiner, Mohammed Milhem
  • Methods for in vitro expansion of hematopoietic stem cells
    Patent number: 7927785
    Abstract: The invention relates to methods of obtaining compositions for generating multipotent hematopoietic stem progenitor cells comprising expansion of hematopoietic stem cells in the presence of HDACI and IDM. Methods of obtaining compositions enriched in hematopoietic megakaryocyte progenitor cells are also provided. Compositions enriched for stem cells and populations of cells obtained therefrom are also provided by the invention.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: April 19, 2011
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Mohammed Milhem, Nadim Mahmud, Donald Lavelle, Yogen Saunthararajah, Joseph De Simone, Ronald Hoffman
  • Methods for in vitro expansion of hematopoietic stem cells
    Publication number: 20050276793
    Abstract: The invention relates to methods of obtaining compositions for generating multipotent hematopoietic stem progenitor cells comprising expansion of hematopoietic stem cells in the presence of HDACI and IDM. Methods of obtaining compositions enriched in hematopoietic megakaryocyte progenitor cells are also provided. Compositions enriched for stem cells and populations of cells obtained therefrom are also provided by the invention.
    Type: Application
    Filed: May 12, 2005
    Publication date: December 15, 2005
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Mohammed Milhem, Nadim Mahmud, Donald Lavelle, Yogen Saunthararajah, Joseph De Simone, Ronald Hoffman