Patents by Inventor Mohammed Reza Mirzazadeh

Mohammed Reza Mirzazadeh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
    Patent number: 10689691
    Abstract: The invention provides for systems, methods, compositions, and kits for the complete characterization of targeted nuclease specificity which necessitates techniques that can assess the full possibility space of off-target activity and genomic stability following genome editing. Also provided are the materials and techniques which enable the comprehensive genomic stability accompanying a range of cellular perturbations, including genome editing (ZFN, TALEN, CRISPR, and future technologies) and disease modeling among other applications.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: June 23, 2020
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Winston Yan, David A. Scott, Aaron Smargon, Mohammed Reza Mirzazadeh, Nicola Crosetto
  • UNBIASED IDENTIFICATION OF DOUBLE-STRAND BREAKS AND GENOMIC REARRANGEMENT BY GENOME-WIDE INSERT CAPTURE SEQUENCING
    Publication number: 20180163265
    Abstract: The invention provides for systems, methods, compositions, and kits for the complete characterization of targeted nuclease specificity which necessitates techniques that can assess the full possibility space of off-target activity and genomic stability following genome editing. Also provided are the materials and techniques which enable the comprehensive genomic stability accompanying a range of cellular perturbations, including genome editing (ZFN, TALEN, CRISPR, and future technologies) and disease modeling among other applications.
    Type: Application
    Filed: June 19, 2017
    Publication date: June 14, 2018
    Inventors: Feng Zhang, Winston Yan, David A. Scott, Aaron Smargon, Mohammed Reza Mirzazadeh, Nicola Crosetto