Abstract: A method for treating Crohn's Disease in a subject in need thereof is provided. The method includes administering rectally to the subject a therapeutically effective amount of a composition comprising roflumilast. The composition may be administered repetitively over a period of days and may contain or be co-administered with one or more agents different from roflumilast that are directed against bowel disease. A suppository dosage form comprising roflumilast and a pharmaceutically acceptable carrier are also provided.

Abstract: Methods and systems for quantifying and minimizing wellbore breakouts are disclosed. The methods include obtaining a mechanical earth model (MEM), determining a critical collapse pressure (CCP) using an inclination angle and the MEM, and determining an initial mud weight based on the CCP. The methods also include generating a breakout analysis using the initial mud weight, the MEM and a numerical modeling algorithm, updating the inclination angle of the planned wellbore, updating the CCP based on the updated inclination angle and the MEM, and updating the breakout analysis using the initial mud weight, the updated CCP, the MEM, and the numerical modeling algorithm. The methods further include selecting the updated CCP based, on the updated inclination angle that meets the stopping condition, calculating a final mud weight for the planned wellbore based on the updated CCP, and conditioning a drilling mud to the final mud weight, using a mud system.

Abstract: A composition includes a polymer having a structure as shown in Formula (I): where x is from 20 to 70, y is from 20 to 30, z is from 1.0 to 10, and p is from 1.0 to 10. A method of making the polymer is also provided. The polymer composition may be used as a wellbore fluid. Also provided is a method of treating a hydrocarbon bearing formation. The method includes introducing the polymer-containing wellbore fluid into a high permeability zone of a hydrocarbon bearing formation such that it blocks at least a portion of the high permeability zone of the hydrocarbon bearing formation, stimulating the hydrocarbon bearing formation thereby creating pathways for hydrocarbon production, and recovering hydrocarbons.

Abstract: The disclosure relates to systems and methods in which aliphatic epoxy resin crosslinked polymers are used in primary cementing applications. The aliphatic epoxy resin crosslinked polymers contain a derivative of a first epoxy resin, a derivative of a second epoxy resin and a polyamine. The first epoxy resin contains bisphenol A and an aliphatic monoglycidyl ether. The second epoxy resin contains a C12-C14 alkyl glycidyl ether.

Abstract: The system can include a multi-lumen chamber can removably connected to and in fluid communication with a proximal end of a mixing lumen and include a first lumen aligned with a second lumen. The first lumen can be configured to include a first constituent in a first cavity. A first plunger can be internally positioned within the first lumen to control flow of the first constituent from the first cavity into the mixing lumen. The first cavity can terminate in a first port in fluid communication with the proximal end of the mixing lumen. The second lumen can be configured to include a second constituent. A second plunger can be internally positioned within the second lumen. The second lumen can terminate in a second port adjacent the first port and in fluid communication with the proximal end of the mixing lumen.

Abstract: A system is disclosed for producing a mixture to deliver to a treatment site. The system can include a first chamber with an inner cavity including a first constituent and an outer cavity concentric with the first cavity and including a second constituent. A partition can be openable and separate the first and second cavities. A second chamber can include a third constituent and be concentric with the first chamber. Moving the first chamber and/or the second chamber relative to the other can cause the partition to open so that the first constituent and the second constituent mix with each other to form a first mixture. Applying a force to the system can cause the first mixture and the third constituent to egress through distal portions of the first and second chambers and mix together to form the mixture for delivery to the treatment site.

Abstract: A system for producing a mixture to deliver to a treatment site. A multi-lumen chamber can be connected to a proximal end of a mixing lumen and include a first lumen aligned and adjacent a second lumen. The first lumen can be configured to include a first constituent in a proximal portion of the first lumen and a second constituent in a distal portion of the first lumen. A first plunger can be internally positioned within the first lumen to distally move the first constituent into the distal portion to mix with the second constituent in a first state to form a first mixture. The first lumen can terminate in a first port. The second lumen is configured to include a third constituent. A second plunger is internally positioned within the second lumen to distally move the third constituent and the first mixture.

Abstract: A system includes a connector with a central lumen. A multi-lumen chamber is removably connected to and in fluid communication with a proximal end of the central lumen. The multi-lumen chamber includes a first lumen aligned and adjacent a second lumen. The first lumen includes a first fluid in a proximal portion of the first lumen and a hydrophilic polymer in a distal portion of the first lumen, a first plunger rod within the first lumen to control flow of the first fluid into the distal portion to mix with the hydrophilic polymer in a first state to form a first mixture, and a first port. The second lumen includes a second fluid, a second plunger rod within the second lumen to distally move the second fluid and the first mixture in a second state, and a second port.

Abstract: A system is disclosed for producing a mixture to deliver to a treatment site. The system includes a mixing lumen attachable to a proximal end of a delivery system. A multi-lumen chamber can be removably connected to a proximal end of the mixing lumen and include a first lumen aligned with a second lumen. The first lumen can be configured to comprise a first constituent in a first state. The first lumen can include a first plunger to move the first constituent from the first lumen to the mixing lumen. The first lumen can terminate in a first port. The second lumen can be configured to include a second constituent. The second lumen can include a second plunger to distally move the second constituent and terminate in a second port. A vial adaptor can be included with a vial having a third constituent.

Abstract: A system is disclosed for producing a mixture to deliver to a treatment site. The system can include a connector with a connector vent so that air in the connector is expellable therethrough. A multi-lumen chamber can be connected to a proximal end of the connector and include a first lumen aligned and adjacent a second lumen. The first lumen can be configured to include a first constituent in a proximal portion of the first lumen, a second constituent in a distal portion of the first lumen, and a first plunger internally positioned within the first lumen to distally move the first constituent into the distal portion to mix with the second constituent in a first state to form a first mixture. The second lumen is configured to include a third constituent and a second plunger rod internally positioned within the second to distally move the third constituent.

Abstract: A system is disclosed for producing a mixture to deliver to a treatment site. The system can include a mixing lumen attachable to a proximal end of a delivery system. A multi-lumen chamber can be connected to a proximal end of the mixing lumen and include a first lumen aligned and adjacent a second lumen. The first lumen can receive a first constituent in a first state. The first lumen can include a first plunger to move the first constituent from the first lumen to the mixing lumen. The second lumen can include a second constituent and a second plunger to distally move the second constituent and the first constituent in a second state. Distally moving the second plunger causes the first constituent and the second constituent to be mixed together within the mixing lumen to form the mixture.

Abstract: A system for treating tissue includes a cap mounted over a distal end of an endoscope, a clip mountable over the cap and including first and second jaws movably connected to one another between an insertion configuration, in which the first and second jaws extend over the cap to receive a target tissue therebetween, a review configuration, in which at least a portion of the clip extends into a field of view of the optical system of an endoscope, and a deployed configuration in which the clip is moved distally off of the cap so that the first and second jaws are drawn toward one another. A control element is configured so that movement proximally through the cap via a first distance moves the clip from the insertion configuration to the review configuration and a second distance moves the clip from the review configuration to the deployed configuration.

Abstract: According to a general aspect, an insertion device includes an elongate member defining a lumen, a handle member movably coupled to the elongate member, a plunger member, at least a portion of the plunger member being disposed within the lumen defined by the elongate member, and an actuation member operatively coupled to the plunger member, the plunger member being configured to move from a first position within the lumen to a second location within the lumen in response to the actuation member being actuated.

Abstract: The disclosed computer-implemented method for mitigating stalkerware by rendering it useless is performed, at least in part, by a computing device comprising at least one processor. The method includes detecting, by the at least one processor in accordance with a security configuration of the computing device, a stalkerware application running in a foreground of the computing device. The method also includes overlaying, by the at least one processor in accordance with the security configuration, the stalkerware application with a window in response to the detecting. The method further includes performing a security action by intercepting one or more user inputs to the stalkerware application via the window, thereby preventing user configuration of the stalkerware application. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The disclosed computer-implemented method for detecting unauthorized use of an application may include (1) receiving, by the computing device, fingerprint data associated with a fingerprint, where the fingerprint data is received from the touchscreen, when a user interface of the application is displayed on the touchscreen, and in an absence of displaying a request for fingerprint data on the touchscreen, (2) comparing the received fingerprint data to a whitelist of authorized fingerprint data to determine a presence of a match, where the authorized fingerprint data indicates at least one fingerprint of at least one user that is authorized to access the application and (3) performing, when the received fingerprint data does not match the whitelist of authorized fingerprint data, a security action. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Methods and systems are provided for preventing the installation of malicious applications using system-level messages. One example method generally includes intercepting a request sent via an operating system of the computing device; determining the request is to access an application in a remote application repository; obtaining information associated with the application from the request; transmitting, over a network, the information to a security server; and receiving, over the network, a security recommendation for the application from the security server.

Abstract: According to a general aspect, an insertion device includes an elongate member defining a lumen, a handle member movably coupled to the elongate member, a plunger member, at least a portion of the plunger member being disposed within the lumen defined by the elongate member, and an actuation member operatively coupled to the plunger member, the plunger member being configured to move from a first position within the lumen to a second location within the lumen in response to the actuation member being actuated.

Abstract: Methods, systems and devices are provided to enable voice activity following a call interruption or when a call experiences or will experience interruption or diminished quality such that call experience is affected to be relayed to the communication device of the other party to the call. When an indication that an active voice call with another communication device is or will experience interruption or diminished quality such that call experience is affected, audio received from a microphone of the communication device may be recorded. A message may be generated from recorded audio and the generated message may be transmitted to the other communication device. Generation and/or transmission of the message may be performed in response to user inputs.

Abstract: Systems and methods for secured computer based assessment are described. In one embodiment, the method comprises capturing of proctoring data at a candidate assessment device from a candidate at predefined time intervals during an examination. The proctoring data includes biometric data, still image, and surround sound associated with the at least one candidate. The proctoring data captured at the candidate assessment device is then transmitted to a central assessment server connected to the candidate assessment device. At the central assessment server, the proctoring data is compared with registration data, of the candidate, stored in the central assessment server. Based on the comparison, malpractice by the candidate during the examination is determined when the proctoring data deviates from the registration data.

Abstract: A computer-implemented method for efficiently backing up data may include (1) identifying a volume scheduled for a backup by a computing system, (2) determining that resource usage of the computing system will fall below a predetermined threshold for a period of time, (3) identifying at least one unit of data in the volume of data to copy to a backup image for the backup during the period of time, (4) in response to determining that the resource usage of the computing system will fall below the predetermined threshold for the period of time, copying the unit of data to the backup image during the period of time, (5) taking the snapshot of the volume, and (6) copying at least one additional unit of data from the snapshot to the backup image to make the backup image consistent with the snapshot. Various other methods, systems, and computer-readable media are also disclosed.