Patents by Inventor Mohan Kaadige
Mohan Kaadige has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240034727Abstract: Compounds having activity as inhibitors of ENPP1 are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, tautomer, stereoisomer, or prodrug thereof, wherein L, R1, R2a, R2b, R2c, R2d, R2e and n are as defined herein. This disclosure provides methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds, and methods for treating disorders associated with ENPP1, including uncontrolled cellular proliferation, cancer and virial or bacterial infections in a mammal.Type: ApplicationFiled: December 1, 2021Publication date: February 1, 2024Inventors: Srinivas Rao Kasibhatla, Sunil Sharma, Mohan Kaadige, Alexis Weston, Trason Thode
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Publication number: 20230348475Abstract: Compounds having activity as anti-cancer agents are provided. The compounds have the following structure (I) or a pharmaceutically acceptable salt, stereoisomer or tautomer, thereof, wherein X, Y, R1, R2, R3R4, R5 and L are as defined herein. This disclosure provides methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds, and methods for treating a CDK7-dependent disease (e.g., cancer).Type: ApplicationFiled: September 17, 2021Publication date: November 2, 2023Inventors: Srinivas Rao KASIBHATLA, Sunil SHARMA, Mohan KAADIGE, Alexis WESTON, Srikanta DANA, Trason THODE
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Publication number: 20220296552Abstract: Disclosed herein are compositions and methods for acutely raising nitric oxide levels in a subject. In one example, the composition can include, an effective amount of a NOS dependent source of nitric oxide; an effective amount of a NOS independent source of nitric oxide; and an effective amount of a myeloperoxidase inhibitor; wherein the composition acutely raises nitric oxide levels in a subject above a level provided by the available sources of nitric oxide in the subject prior to administration of the composition. Further presented is a method of treating a subject for a condition or disorder that is response to nitric oxide therapy, including: acutely raising nitric oxide levels in a subject by simultaneously increasing biosynthesis of nitric oxide, increasing nitrate/nitrite levels, and inhibiting meyloperoxidase activity.Type: ApplicationFiled: February 7, 2022Publication date: September 22, 2022Applicant: Nature's Sunshine Products, Inc.Inventors: Matthew L. Tripp, Clinton J. Dahlberg, John G. Babish, Mohan Kaadige, Wei Gao
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Patent number: 11331363Abstract: Compositions comprising apple, grape, green tea, and olive extracts are presented herein. This synergistic formulations apple, grape, green tea, and olive extract are in amounts that provide a greater antioxidant activity or protein kinase modulating activity than provided by an equivalent amount of any one extract or a sum of the extracts. Further presented are methods of regulating oxidative stress, disease-associated protein kinase activity, and enhancing the therapeutic effect of a primary therapeutic agent. Also presented are methods of making an activity enhancing composition for regulating oxidative stress, disease-associated protein kinase activity, and enhancing the therapeutic effect of a primary therapeutic agent.Type: GrantFiled: October 8, 2019Date of Patent: May 17, 2022Assignee: Nature's Sunshine Products, Inc.Inventors: Matthew L. Tripp, Clinton J. Dahlberg, John G. Babish, Wei Gao, Mohan Kaadige, Sheryl Krig, Xiaolan Kou, Zhe Khang, Joseph Ou
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Publication number: 20220144841Abstract: Compounds having activity as cancer agents are provided. The compounds have the following structure (I) or a pharmaceutically acceptable salts, stereoisomers, tautomers, thereof, wherein R1, R2, R3 and L are as defined herein. This disclosure provides methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds, and methods for treating a CDK7-dependent disease (e.g., cancer).Type: ApplicationFiled: March 13, 2020Publication date: May 12, 2022Inventors: Hariprasad VANKAYALAPATI, Zhaoliang LI, Trason THODE, Mohan KAADIGE, Alexis WESTON, Sunil SHARMA
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Patent number: 11241406Abstract: Disclosed herein are compositions and methods for acutely raising nitric oxide levels in a subject. In one example, the composition can include, an effective amount of a NOS dependent source of nitric oxide; an effective amount of a NOS independent source of nitric oxide; and an effective amount of a myeloperoxidase inhibitor; wherein the composition acutely raises nitric oxide levels in a subject above a level provided by the available sources of nitric oxide in the subject prior to administration of the composition. Further presented is a method of treating a subject for a condition or disorder that is response to nitric oxide therapy, including: acutely raising nitric oxide levels in a subject by simultaneously increasing biosynthesis of nitric oxide, increasing nitrate/nitrite levels, and inhibiting myeloperoxidase activity.Type: GrantFiled: August 28, 2016Date of Patent: February 8, 2022Assignee: Nature's Sunshine Products, Inc.Inventors: Matthew L. Tripp, Clinton J. Dahlberg, John G. Babish, Mohan Kaadige, Wei Gao
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Methods and compositions to improve weight loss and cardiometabolic health beyond diet and excercise
Patent number: 11122832Abstract: A weight loss system is presented herein. In one embodiment, the weight loss system that accelerates weight loss in a subject eating a caloric restricted diet with a minimum daily protein intake of about 3 oz. and engaging in daily physical activity equivalent to about 5,000 steps per day is presented. The weight loss system can comprise an effective amount of: an antimicrobial component that includes berberine, cinnamon and curcumin; fish oil; a probiotic component that includes Lactobacillus spp., Bifidobacterium spp., and Streptococcus spp.; an antioxidant, phytochemical component that includes apple extract, grape extract, green tea extract, and olive extract; and a vitamin component that includes vitamins A, B, C, D, and E. The weight loss system can stimulate a weight loss of at least 3% more than if not administered to the subject. Further presented herein is a method of facilitating weight loss in a subject and a method of improving the health of a subject participating in a weight loss program.Type: GrantFiled: March 6, 2017Date of Patent: September 21, 2021Assignee: Nature's Sunshine Products, Inc.Inventors: Matthew L. Tripp, Clinton J. Dahlberg, John G. Babish, Joseph Lamb, Joseph J. Ou, Sarah Elison, Wei Gao, Mohan Kaadige, Holly Brabazon -
Publication number: 20200246412Abstract: Compositions comprising apple, grape, green tea, and olive extracts are presented herein. This synergistic formulations apple, grape, green tea, and olive extract are in amounts that provide a greater antioxidant activity or protein kinase modulating activity than provided by an equivalent amount of any one extract or a sum of the extracts. Further presented are methods of regulating oxidative stress, disease-associated protein kinase activity, and enhancing the therapeutic effect of a primary therapeutic agent. Also presented are methods of making an activity enhancing composition for regulating oxidative stress, disease-associated protein kinase activity, and enhancing the therapeutic effect of a primary therapeutic agent.Type: ApplicationFiled: October 8, 2019Publication date: August 6, 2020Applicant: Nature's Sunshine Products, Inc.Inventors: Matthew L. Tripp, Clinton J. Dahlberg, John G. Babish, Wei Gao, Mohan Kaadige, Sheryl Krig, Xiaolan Kou, Zhe Khang, Joseph Ou
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Patent number: 10434131Abstract: Compositions comprising apple, grape, green tea, and olive extracts are presented herein. This synergistic formulations apple, grape, green tea, and olive extract are in amounts that provide a greater antioxidant activity or protein kinase modulating activity than provided by an equivalent amount of any one extract or a sum of the extracts. Further presented are methods of regulating oxidative stress, disease-associated protein kinase activity, and enhancing the therapeutic effect of a primary therapeutic agent. Also presented are methods of making an activity enhancing composition for regulating oxidative stress, disease-associated protein kinase activity, and enhancing the therapeutic effect of a primary therapeutic agent.Type: GrantFiled: March 16, 2016Date of Patent: October 8, 2019Assignee: Nature's Sunshine Products, Inc.Inventors: Matthew L. Tripp, Clinton J. Dahlberg, John G. Babish, Wei Gao, Mohan Kaadige, Sheryl Krig, Xiaolan Kou, Zhe Khang, Joseph Ou
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METHODS AND COMPOSITIONS TO IMPROVE WEIGHT LOSS AND CARDIOMETABOLIC HEALTH BEYOND DIET AND EXCERCISE
Publication number: 20190261669Abstract: A weight loss system is presented herein. In one embodiment, the weight loss system that accelerates weight loss in a subject eating a caloric restricted diet with a minimum daily protein intake of about 3 oz. and engaging in daily physical activity equivalent to about 5,000 steps per day is presented. The weight loss system can comprise an effective amount of: an antimicrobial component that includes berberine, cinnamon and curcumin; fish oil; a probiotic component that includes Lactobacillus spp., Bifidobacterium spp., and Streptococcus spp.; an antioxidant, phytochemical component that includes apple extract, grape extract, green tea extract, and olive extract; and a vitamin component that includes vitamins A, B, C, D, and E. The weight loss system can stimulate a weight loss of at least 3% more than if not administered to the subject. Further presented herein is a method of facilitating weight loss in a subject and a method of improving the health of a subject participating in a weight loss program.Type: ApplicationFiled: March 6, 2017Publication date: August 29, 2019Applicant: Nature's Sunshine Products, Inc.Inventors: Matthew L. Tripp, Clinton J. Dahlberg, John G. Babish, Joseph Lamb, Joseph J. Ou, Sarah Elison, Wei Gao, Mohan Kaadige, Holly Brabazon -
Publication number: 20180263944Abstract: Disclosed herein are compositions and methods for acutely raising nitric oxide levels in a subject. In one example, the composition can include, an effective amount of a NOS dependent source of nitric oxide; an effective amount of a NOS independent source of nitric oxide; and an effective amount of a myeloperoxidase inhibitor; wherein the composition acutely raises nitric oxide levels in a subject above a level provided by the available sources of nitric oxide in the subject prior to administration of the composition. Further presented is a method of treating a subject for a condition or disorder that is response to nitric oxide therapy, including: acutely raising nitric oxide levels in a subject by simultaneously increasing biosynthesis of nitric oxide, increasing nitrate/nitrite levels, and inhibiting meyloperoxidase activity.Type: ApplicationFiled: August 28, 2016Publication date: September 20, 2018Applicant: Nature's Sunshine Products, Inc.Inventors: Matthew L. Tripp, Clinton J. Dahlberg, John G. Babish, Mohan Kaadige, Wei Gao
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Publication number: 20170020948Abstract: Compositions comprising apple, grape, green tea, and olive extracts are presented herein. This synergistic formulations apple, grape, green tea, and olive extract are in amounts that provide a greater antioxidant activity or protein kinase modulating activity than provided by an equivalent amount of any one extract or a sum of the extracts. Further presented are methods of regulating oxidative stress, disease-associated protein kinase activity, and enhancing the therapeutic effect of a primary therapeutic agent. Also presented are methods of making an activity enhancing composition for regulating oxidative stress, disease-associated protein kinase activity, and enhancing the therapeutic effect of a primary therapeutic agent.Type: ApplicationFiled: March 16, 2016Publication date: January 26, 2017Applicant: Nature's Sunshine Products, Inc.Inventors: Matthew L. Tripp, Clinton J. Dahlberg, John G. Babish, Wei Gao, Mohan Kaadige, Sheryl Krig, Xiaolan Kou, Zhe Khang, Joseph Ou