Abstract: Presented is a non-invasive and non-medication treatment system for patients suffering from mental dysfunction or disorder such as anxiety, depression and chronic pain. The system uses near-infrared spectroscopy (NIRS) sensors for detecting or monitoring brain activity of a user/patient, and then subject to detecting a low brain activity area in a patient's brain, facilitates a patient to apply Photobiomodulation Therapy (PBMT) and/or transcranial Direct Current Stimulation (tDCS) to treat the brain dysfunction. The simulation procedure adapted by the patient is either auto chosen by a program product embodied in the patient device having machine learning and artificial intelligence capabilities or manually fed by the patient over the patient device.