Abstract: The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-5 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-5, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma.

Abstract: The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.

Abstract: A multi-protocol storage appliance serves file and block protocol access to information stored on storage devices in an integrated manner for both network attached storage (NAS) and storage area network (SAN) deployments. A storage operating system of the appliance implements a file system that cooperates with novel virtualization modules to provide a virtualization system that “virtualizes” the storage space provided by the devices. Notably, the file system provides volume management capabilities for use in block-based access to the information stored on the devices. The virtualization system allows the file system to logically organize the information as named file, directory and virtual disk (vdisk) storage objects to thereby provide an integrated NAS and SAN appliance approach to storage by enabling file-based access to the files and directories, while further enabling block-based access to the vdisks.

Abstract: A storage virtualization selection technique “automates” a virtualization selection process to create virtual disk (vdisk) storage objects over a volume of a file system implemented by a storage operating system of a multi-protocol storage appliance. The file system provides a virtualization system that aggregates physical storage of a set of disks or portions (e.g., extents) of disks into a pool of blocks that can be dynamically allocated to form a vdisk. The file system also provides reliability guarantees for the vdisks in accordance with its underlying architecture. That is, the file system organizes its storage within volumes created among the managed disks. The vdisk is thereafter created as a storage object within a volume and, thus, inherits the underlying reliability configuration associated with that volume.

Abstract: The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.