Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K? signaling with the compounds and compositions of the disclosure.

Abstract: A method of manufacturing an optical fiber sensing device includes steps of moving an optical fiber having a core linearly along a first direction, during the moving, directly writing a number of nanograting structures into the core using a laser beam generated by an ultrafast laser system, wherein the number of nanograting structures form a number of scattering points; and forming an energy transducing element on an outer surface of the optical fiber, wherein the number of scattering points is/are structured and configured to scatter light out of fiber core and into the transducing element to provide local power for the optical fiber sensing device. A system for performing the method is also provided.

Abstract: Example implementations described herein are directed to project management systems and milestone management. In example implementations, for input of a project having project data and employee data, such implementations involve executing feature extraction on the project data and the employee data to generate features; executing a self-profiling algorithm configured with unsupervised machine learning on the generated features to derive clusters and anomalies of the project; executing a performance monitoring process on the generated features to determine a probability of a transition to a milestone associated with a key performance indicator; and executing a supervised machine learning model on the generated features, the derived clusters, the derived anomalies, the probability of the transition to the milestone associated with a key performance indicator to generate a predicted performance of the project.