Patents by Inventor Mohd Firouz Mohd Mustapa

Mohd Firouz Mohd Mustapa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Materials and complexes for the delivery of biologically-active materials to cells
    Patent number: 9399016
    Abstract: The invention provides a peptide derivative of formula A-B-C wherein A is a polycationic nucleic acid-binding component; B is a spacer element peptide that is susceptible to cleavage within a cell; and C is a cell surface receptor binding component. The invention also provides a lipid derivative of general formula (I): (PEG)q-Linker-Spacer-Cationic headgroup-carbon skeleton-(hydrophobic chain)o wherein: the Linker is a group susceptible to cleavage within a cell; the Spacer is a group linking the Linker to the Cationic headgroup; q denotes the number of PEG chains and q=1, 2 or 3; o denotes the number of hydrophobic chains and o=1, 2 or 3; the carbon skeleton is a group linking the hydrophobic chains to the cationic headgroup. The peptide and lipid derivatives find use in non-viral gene delivery systems.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: July 26, 2016
    Assignee: UCL BUSINESS PLC
    Inventors: Stephen Lewis Hart, Stephanie Grosse, Alethea Bernice Tabor, John Bosco Wong, Martin Elbs, Helen Claire Hailes, Mohd Firouz Mohd Mustapa
  • Materials and Complexes for the Delivery of Biologically-Active Materials to Cells
    Publication number: 20100184831
    Abstract: The invention provides a peptide derivative of formula A-B-C wherein A is a polycationic nucleic acid-binding component; B is a spacer element peptide that is susceptible to cleavage within a cell; and C is a cell surface receptor binding component. The invention also provides a lipid derivative of general formula (I): (PEG)q-Linker-Spacer-Cationic headgroup-carbon skeleton-(hydrophobic chain)o wherein: the Linker is a group susceptible to cleavage within a cell; the Spacer is a group linking the Linker to the Cationic headgroup; q denotes the number of PEG chains and q=1, 2 or 3; o denotes the number of hydrophobic chains and o=1, 2 or 3; the carbon skeleton is a group linking the hydrophobic chains to the cationic headgroup. The peptide and lipid derivatives find use in non-viral gene delivery systems.
    Type: Application
    Filed: May 30, 2007
    Publication date: July 22, 2010
    Inventors: Stephen Lewis Hart, Stephanie Grosse, Alethea Bernice Tabor, John Bosco Wong, Martin Elbs, Helen Claire Hailes, Mohd Firouz Mohd Mustapa