Abstract: Pesticides useful in the treatment of plant disease are provided. A pesticide includes: a nanocellulose scaffold with a cellulose nanocrystal (CNC) that is modified to include a diamine or quaternary amine; and a metal nanoparticle conjugated to the nanocellulose scaffold via the diamine or quaternary amine. Conjugation of the metal nanoparticle to the nanocellulose scaffold can facilitate improved surface adhesion of the metal nanoparticle on a plant surface, thus rendering the metal nanoparticle less amenable to removal from the plant by environmental factors. The enhanced surface adhesion can extend the duration of the antibacterial, antifungal, and/or antiviral action of the metal nanoparticle and reduce the number and/or frequency of pesticide applications required for plant treatment. The pesticide can include a plurality of modified CNCs and metal nanoparticles conjugated to the modified CNCs. Methods for treating plant disease and methods for synthesizing a pesticide are also provided.

Abstract: A particle that includes a core and one or more layers. The core includes a fertilizer element. The one or more layers may include a polycation polymer and/or a polyanion polymer. Compositions include a plurality of particles and methods of using the particles and compositions containing the same.

Abstract: The invention relates to acetoacetylated lignin resin compositions comprising the reaction product of lignin and an acetoacetate ester. The invention also relates to (meth)acrylated lignin resin compositions comprising the reaction product of lignin and a (meth)acrylic compound. The invention also relates to methods of making the acetoacetylated and (meth)acrylated lignin resin compositions. The invention also relates to curable coating compositions comprising the acetoacetylated and (meth)acrylated lignin resin compositions. The invention also relates to methods of making the curable coating compositions of the invention. The invention also relates to methods of applying curable coating compositions of the invention to substrates. The invention also relates to articles of manufacture comprising a curable coating composition of the invention and a method of making such article.

Abstract: The presently disclosed invention relates to products and methods of treating cancer in a patient comprising administering to the patient a pharmaceutically therapeutic dose of a chemotherapeutic, or any pharmaceutically acceptable salt, solvate, or prodrug thereof, conjugated to a nanocarrier. According to a further embodiment, the chemotherapeutic has a primary (1°) amine (—NH2) group in within a pharmaceutical structure of the chemotherapeutic structure. According to a further embodiment, the chemotherapeutic is one of a platinum-based pharmaceutical and an Anthracycline family pharmaceutical. According to a further embodiment, the chemotherapeutic is one of gemcitabine, methotrexate, cisplatin, oxaliplatin, doxorubicin, daunorubicine, idarubicine, and epirubicine. According to a further embodiment, the chemotherapeutic is either attached to the nanocarrier by means that includes covalent bonds or is attached by means that does not included covalent bonds.

Abstract: Disclosed are nanoparticles comprising a polymer carrier formed from a poly(ethylene glycol) and a poly(carbonate) copolymer which encapsulates a cargo entity such as an ERK inhibitor and/or chemotherapeutic agent. Therapeutic uses of the nanoparticles are also described, including methods of treating a cancer such as pancreatic cancer.

Abstract: The invention relates to acetoacetylated lignin resin compositions comprising the reaction product of lignin and an acetoacetate ester. The invention also relates to (meth)acrylated lignin resin compositions comprising the reaction product of lignin and a (meth)acrylic compound. The invention also relates to methods of making the acetoacetylated and (meth)acrylated lignin resin compositions. The invention also relates to curable coating compositions comprising the acetoacetylated and (meth)acrylated lignin resin compositions. The invention also relates to methods of making the curable coating compositions of the invention. The invention also relates to methods of applying curable coating compositions of the invention to substrates. The invention also relates to articles of manufacture comprising a curable coating composition of the invention and a method of making such article.