Abstract: A microfluidic device includes a channel having converging and diverging portions, and a plurality of magnets arranged next to the channel. The plurality of magnets is arranged to apply a magnetic field across the channel to capture magnetic particles in diverging portions of the channel where a velocity of a liquid in the channel is reduced.

Abstract: A stimulus-responsive carrier, a method for making and a method of using the same are disclosed. The stimulus-responsive carrier comprises a polymeric component comprising poly(N-isopropylacrylamide) (PNIPAM), a copolymer comprising units derived from N-isopropylacrylamide and acrylic acid (PNIPAM-AA), poly N-vinylpyrrolidone, a copolymer of N-isopropylacrylamide and hydroxymethylacrylamide (PNIPAM-HMAAm), a copolymer of N-isopropylacrylamide and allylamine (poly(NIPAAM-co-allylamine)), poly 2-(2-methoxyethoxy) ethyl methacrylate, or any combination thereof; and a second component disposed within the polymeric component, the second component comprising a hydrogel, wherein the second component has a different composition than the polymeric component. The stimulus-responsive carrier is responsive to a stimulus comprising a temperature change, a pH change, application of a magnetic field, or any combination thereof.

Abstract: A wound covering includes a flexible main body, and a sensor element incorporated into the main body. The sensor element includes a mesh formed from a plurality of fibers, and is configured to undergo a change in appearance in response to a change in a parameter associated with wound exudate. The wound covering further includes a supply of therapeutic agent configured to diffuse therapeutic agent from the wound covering into a wound when the wound covering is placed on a wound.

Abstract: Disclosed herein are embodiments of a composition comprising a matrix, a plurality of microparticles and a therapeutic agent. The therapeutic agent may be encapsulated in the microparticles, and/or the microparticles may be dispersed in the matrix. The composition may be a mesh or a sheet, and may further comprise a second therapeutic agent, and optionally a second microparticle and/or a second matrix. In particular embodiments, the matrix is a hydrogel. Methods for making and using the composition are also disclosed, and in certain embodiments, the composition is useful for treating cancer, such as brain cancer.

Abstract: A machine-to-machine (M2M) gateway is configured with a service capability layer (SCL) and includes a storage unit, a network interface and a processor. The storage unit stores rules for allocating resources in a resource tree. The resources include a functions collection resource of function sub-resources, at least one of which represents a function that generates contextual cues from content and a corresponding semantic description. The processor also receives requests to create new function sub-resources in the collection and creates new function sub-resources in the resource tree in response to the requests. The processor receives other requests targeting the new function sub-resources. The processor generates high-level contextual information, using the new function, based on content data and the associated semantic description of the content data received in the other requests, and routes data in the M2M network based on the generated information.

Abstract: A stimulus-responsive carrier, a method for making and a method of using the same are disclosed. The stimulus-responsive carrier comprises a polymeric component comprising poly(N-isopropylacrylamide) (PNIPAM), a copolymer comprising units derived from N-isopropylacrylamide and acrylic acid (PNIPAM-AA), poly N-vinylpyrrolidone, a copolymer of N-isopropylacrylamide and hydroxymethylacrylamide (PNIPAM-HMAAm), a copolymer of N-isopropylacrylamide and allylamine (poly(NIPAAM-co-allylamine)), poly 2-(2-methoxyethoxy) ethyl methacrylate, or any combination thereof; and a second component disposed within the polymeric component, the second component comprising a hydrogel, wherein the second component has a different composition than the polymeric component. The stimulus-responsive carrier is responsive to a stimulus comprising a temperature change, a pH change, application of a magnetic field, or any combination thereof.

Abstract: A machine-to-machine (M2M) gateway is configured with a service capability layer (SCL) and includes a storage unit, a network interface and a processor. The storage unit stores rules for allocating resources in a resource tree. The resources include a functions collection resource of function sub-resources, at least one of which represents a function that generates contextual cues from content and a corresponding semantic description. The processor also receives requests to create new function sub-resources in the collection and creates new function sub-resources in the resource tree in response to the requests. The processor receives other requests targeting the new function sub-resources. The processor generates high-level contextual information, using the new function, based on content data and the associated semantic description of the content data received in the other requests, and routes data in the M2M network based on the generated information.

Abstract: Devices, computer readable media, and methods for supporting services at an application service layer (ASL) are disclosed. The ASL may be a machine-to-machine (M2M) services capability layer (SCL). Content functions may interpret the data to generate a semantic description of the data. Semantic information associated with data may be stored. Context aware functions may process the semantic description of the data to generate lower level contextual cues. Context aware reasoning functions may process the lower level contextual cues to deduce higher level context. An application or a second ASL may use the contextual cues and the situational context to trigger an action. The ASL may create a trigger condition based on a received message. The ASL may invoke a function based on detecting a trigger condition. The ASL may perform a command based on a received command. The ASL may use a objective function and feedback to control a device.

Abstract: The present disclosure pertains to apparatus and methods for positioning the angular orientation and depth positioning of an acetabular component during hip arthroplasty procedures. The apparatus comprises a positioning member and guiding member set according to a preoperatively determined angular orientation derived from a pelvic radiograph or radiographs in accordance with the methods provided.