Patents by Inventor Mohsen Sharifzadeh
Mohsen Sharifzadeh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230086512Abstract: The present disclosure relates to optical methods and devices based on pulsate behavior of blood and optical absorption spectroscopy to measure the level of water and/or other substances or compounds, such as an alcohol or lipid, in the blood and the tissues surrounding blood vessels and arteries.Type: ApplicationFiled: November 30, 2022Publication date: March 23, 2023Inventor: Mohsen Sharifzadeh
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Patent number: 11547331Abstract: The present disclosure relates to optical methods and devices based on pulsate behavior of blood and optical absorption spectroscopy to measure the level of water and/or other substances or compounds, such as an alcohol or lipid, in the blood and the tissues surrounding blood vessels and arteries.Type: GrantFiled: August 10, 2016Date of Patent: January 10, 2023Inventor: Mohsen Sharifzadeh
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Publication number: 20220000358Abstract: The present disclosure provides improved techniques for imaging and/or measuring a subject's eye. Various aspects of the present disclosure relate to a portable imaging and/or measuring apparatus comprising one or more imaging and/or measuring devices. Some aspects of the present disclosure relate to an imaging and/or measuring device comprising an adjustable flexure having one or more lenses therein. Some aspects of the present disclosure relate to an imaging and/or measuring device comprising an adjustable flexure configured to provide variable diopter compensation. Some aspects of the present disclosure relate to a method comprising imaging and/or measuring a person's eye using an adjustable flexure within an imaging and/or measuring device, the adjustable flexure having one or more lenses therein. Some aspects of the present disclosure relate to a method comprising providing variable diopter compensation for imaging and/or measuring a person's eye using an adjustable flexure.Type: ApplicationFiled: July 1, 2021Publication date: January 6, 2022Inventors: Jacob Coumans, Tyler S. Ralston, Mark M. Meyers, Maurizio Arienzo, Paul E. Glenn, Jonathan M. Rothberg, Mohsen Sharifzadeh
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Patent number: 9968250Abstract: A method, system, and computer program product are disclosed for diagnosing a condition of an eye such as macular degeneration and/or cataracts. The system may include an optical system, which may project light at an eye and record lipofuscin fluorescence from a retina of the eye to form an image of the retina. A computing device may process the image to apply one or more image acceptance criteria and/or one or more image clarity criteria. If the image fails to meet the one or more image acceptance criteria, the image may be re-taken. Based on the level of conformance of the image to the one or more image clarity criteria, the system may indicate that the macular pigment level cannot be provided with confidence, indicate that the eye likely has one or more cataracts, and/or calculate and provide the macular pigment content based on a correction factor, if needed.Type: GrantFiled: November 7, 2014Date of Patent: May 15, 2018Assignee: Image Technologies CorporationInventors: Mohsen Sharifzadeh, Werner Gellermann
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Patent number: 9814417Abstract: Methods and apparatus are disclosed which facilitate the rapid, noninvasive and quantitative measurement of the concentration of flavonoid compounds, as well as their isomers and metabolites, in biological tissue such as human skin. Low-intensity, visible-light illumination of intact tissue provides for high spatial resolution, and allows for precise quantification of the flavonoid levels in the tissue. The preferred embodiments make use of a previously unknown, low-oscillator strength, optical absorption transition of flavonoids. This makes it possible to optically excite flavonoids in living human tissue outside the absorption range of other, potentially confounding skin chromophores.Type: GrantFiled: January 13, 2009Date of Patent: November 14, 2017Assignee: Longevity Link CorporationInventors: Mohsen Sharifzadeh, Igor V. Ermakov, Werner Gellermann
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Publication number: 20150238074Abstract: A method, system, and computer program product are disclosed for diagnosing a condition of an eye such as macular degeneration and/or cataracts. The system may include an optical system, which may project light at an eye and record lipofuscin fluorescence from a retina of the eye to form an image of the retina. A computing device may process the image to apply one or more image acceptance criteria and/or one or more image clarity criteria. If the image fails to meet the one or more image acceptance criteria, the image may be re-taken. Based on the level of conformance of the image to the one or more image clarity criteria, the system may indicate that the macular pigment level cannot be provided with confidence, indicate that the eye likely has one or more cataracts, and/or calculate and provide the macular pigment content based on a correction factor, if needed.Type: ApplicationFiled: March 11, 2014Publication date: August 27, 2015Applicant: Image Technologies CorporationInventors: Mohsen Sharifzadeh, Werner Gellermann, Masayuki Yoshino, Tokio Ueno, Masahiko Kobayashi
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Publication number: 20150238075Abstract: A method, system, and computer program product are disclosed for diagnosing a condition of an eye such as macular degeneration and/or cataracts. The system may include an optical system, which may project light at an eye and record lipofuscin fluorescence from a retina of the eye to form an image of the retina. A computing device may process the image to apply one or more image acceptance criteria and/or one or more image clarity criteria. If the image fails to meet the one or more image acceptance criteria, the image may be re-taken. Based on the level of conformance of the image to the one or more image clarity criteria, the system may indicate that the macular pigment level cannot be provided with confidence, indicate that the eye likely has one or more cataracts, and/or calculate and provide the macular pigment content based on a correction factor, if needed.Type: ApplicationFiled: November 7, 2014Publication date: August 27, 2015Inventors: Mohsen Sharifzadeh, Werner Gellermann
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Publication number: 20140058224Abstract: A method for measuring and quantifying biological compounds is described. A first side of a sample is illuminated with a light source. Light transmitted from a second side of the sample is detected. The second side of the sample is opposite the first side of the sample. A result is obtained based on the detected light.Type: ApplicationFiled: August 21, 2012Publication date: February 27, 2014Applicant: Opticks, Inc.Inventors: Werner Gellermann, Mohsen Sharifzadeh
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Patent number: 8326405Abstract: Macular pigments are measured by spectrally selective lipofuscin detection. Light from a light source that emits light at a selected range of wavelengths that overlap the absorption band of macular carotenoids is directed onto macular tissue of an eye for which macular pigment levels are to be measured. Emitted light is then collected from the macular tissue. The collected light is filtered so that the collected light includes lipofuscin emission from the macular tissue at an excitation wavelength that lies outside the macular pigment absorption range and outside the excitation range of interfering fluorophores. The collected light is quantified at each of a plurality of locations in the macular tissue and the macular pigment levels in the macular tissue are determined from the differing lipofuscin emission intensities in the macula and peripheral retina.Type: GrantFiled: December 9, 2011Date of Patent: December 4, 2012Assignee: The University of Utah Research FoundationInventors: Werner Gellermann, Mohsen Sharifzadeh
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Publication number: 20120081668Abstract: Macular pigments are measured by spectrally selective lipofuscin detection. Light from a light source that emits light at a selected range of wavelengths that overlap the absorption band of macular carotenoids is directed onto macular tissue of an eye for which macular pigment levels are to be measured. Emitted light is then collected from the macular tissue. The collected light is filtered so that the collected light includes lipofuscin emission from the macular tissue at an excitation wavelength that lies outside the macular pigment absorption range and outside the excitation range of interfering fluorophores. The collected light is quantified at each of a plurality of locations in the macular tissue and the macular pigment levels in the macular tissue are determined from the differing lipofuscin emission intensities in the macula and peripheral retina.Type: ApplicationFiled: December 9, 2011Publication date: April 5, 2012Applicant: The University of Utah Research FoundationInventors: Werner Gellerman, Mohsen Sharifzadeh
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Patent number: 7914147Abstract: A method for optical detection of lipofuscin concentrations in the retina is described. A subject's eye is exposed to a light source. Light emitted from the subject's eye is detected. Levels of lipofuscin are determined from the emitted light. A system for optical detection of lipofuscin in the retina is described. The system includes a light source to generate light. The system includes an optical detector in optical communication with the light source. The optical detector is configured to detect light emitted from a subject's eye. A computing device in electronic communication with the optical detector is included in the system to determine levels of lipofuscin from the emitted light.Type: GrantFiled: March 26, 2008Date of Patent: March 29, 2011Assignee: Image Technologies CorporationInventors: Mohsen Sharifzadeh, Werner Gellermann
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Publication number: 20100179435Abstract: Methods and apparatus are disclosed which facilitate the rapid, noninvasive and quantitative measurement of the concentration of flavonoid compounds, as well as their isomers and metabolites, in biological tissue such as human skin. Low-intensity, visible-light illumination of intact tissue provides for high spatial resolution, and allows for precise quantification of the flavonoid levels in the tissue. The preferred embodiments malce use of a previously unknown, low-oscillator strength, optical absorption transition of flavonoids. This malces it possible to optically excite flavonoids in living human tissue outside the absorption range of other, potentially confounding skin chromophores.Type: ApplicationFiled: January 13, 2009Publication date: July 15, 2010Inventors: Mohsen Sharifzadeh, Igor V. Ermakov, Werner Gellermann
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Publication number: 20100049057Abstract: Macular pigments are measured by spectrally selective lipofuscin detection. Light from a light source that emits light at a selected range of wavelengths that overlap the absorption band of macular carotenoids is directed onto macular tissue of an eye for which macular pigment levels are to be measured. Emitted light is then collected from the macular tissue. The collected light is filtered so that the collected light includes lipofuscin emission from the macular tissue at an excitation wavelength that lies outside the macular pigment absorption range and outside the excitation range of interfering fluorophores. The collected light is quantified at each of a plurality of locations in the macular tissue and the macular pigment levels in the macular tissue are determined from the differing lipofuscin emission intensities in the macula and peripheral retina.Type: ApplicationFiled: April 15, 2009Publication date: February 25, 2010Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: Werner Gellerman, Mohsen Sharifzadeh
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Publication number: 20090244484Abstract: A method for optical detection of lipofuscin concentrations in the retina is described. A subject's eye is exposed to a light source. Light emitted from the subject's eye is detected. Levels of lipofuscin are determined from the emitted light. A system for optical detection of lipofuscin in the retina is described. The system includes a light source to generate light. The system includes an optical detector in optical communication with the light source. The optical detector is configured to detect light emitted from a subject's eye. A computing device in electronic communication with the optical detector is included in the system to determine levels of lipofuscin from the emitted light.Type: ApplicationFiled: March 26, 2008Publication date: October 1, 2009Applicant: Gluta Scan, Inc.Inventors: Mohsen Sharifzadeh, Werner Gellermann
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Publication number: 20060134004Abstract: Methods and apparatus are provided for the noninvasive detection and measurement of macular pigments such as carotenoids in macular tissue. In one technique, lipoftiscin autofluorescence spectroscopy is utilized for macular pigment measurements. In autofluorescence spectroscopy, the emission of lipoftiscin is excited at two wavelengths: one wavelength that overlaps both the macular pigment and lipofuscin absorption and another wavelength that lies outside the macular pigment absorption range but that still excites the lipofuscin emission. The macular pigment absorption is then derived from the different lipoftiscin emission intensities in the macula and peripheral retina. In another technique, both autofluorescence spectroscopy, as described above, and resonance Raman spectroscopy are used to identify and quantify the presence of carotenoids in macular tissue. In using resonance Raman spectroscopy, laser light is directed onto the eye tissue and the scattered light is then spectrally filtered and detected.Type: ApplicationFiled: December 21, 2004Publication date: June 22, 2006Inventors: Werner Gellermann, Mohsen Sharifzadeh, Igor Ermakov, Paul Bernstein