Abstract: The present disclosure provides high concentration injectable particle suspensions of therapeutic biologics that permit administration without the need for resuspension. In particular, the compositions disclosed herein are highly concentrated low volume injectable particle suspensions that do not require manual premixing or resuspension prior to administration.

Abstract: The present disclosure relates to methods that enable the continuous formation of droplets and dehydration of droplets to provide pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled continuous droplet formation and dehydration that produce circular particles having low internal void spaces comprising bioactive therapeutic biologies.