Abstract: Described herein are donor vectors and systems for use in in vivo dual recombinase-mediated cassette exchange. Also described are animal models for consistent, rigorous, and facile investigation of transgene expression. Further described are methods of screening for therapeutic drugs using these animal models, and methods of treatment.

Abstract: The present invention describes methods for treating idiopathic short stature. Described herein are also methods of increasing a subject’s height. The methods involve administering an effective amount of a pan FGFR inhibitor or a selective FGFR inhibitor to the subject. An example of an FGRF inhibitor used in the methods described herein is erdafitinib.

Abstract: Described herein are donor vectors and systems for use in in vivo dual recombinase-mediated cassette exchange. Also described are animal models for consistent, rigorous, and facile investigation of transgene expression. Further described are methods of screening for therapeutic drugs using these animal models, and methods of treatment.

Abstract: Described herein are donor vectors and systems for use in dual recombinase-mediated cassette exchange. Also described herein are animal models and human cells for consistent, rigorous, and facile investigation of transgene expression. Further described herein are methods of screening for therapeutic drugs using these animal models, and methods of treatment.

Abstract: Systems and methods for monitoring pulsatile flows are disclosed. One method includes obtaining a plurality of magnetic resonance imaging (MRI) scans of a biological structure, acquired consecutively in time, each of the MRI scans acquired using a modified True FISP sequence. The method also includes assembling the plurality of scans into a video file of the biological structure and identifying pulsatile features within the video file.

Abstract: Described herein are composition and methods related to targeting the Nf1-Ras-Ets axis, that when perturbed, is identified as playing a role in initiation and maintenance in glioma. A postnatal, mosaic, autochthonous, glioma model that captures the first hours and days of gliomagenesis in more resolution than conventional genetically engineered mouse models of cancer demonstrates that disruption of the Nf1-Ras pathway in the ventricular zone at multiple signaling nodes uniformly results in rapid neural stem cell depletion, progenitor hyperproliferation, and gliogenic lineage restriction. By abolishing Ets subfamily activity, which is upregulated downstream of Ras, there is block of glioma initiation, thereby providing new therapeutic avenues for targeting glioma.

Abstract: Described herein are donor vectors and systems for use in in vivo dual recombinase-mediated cassette exchange. Also described are animal models for consistent, rigorous, and facile investigation of transgene expression.

Abstract: A system supporting perioperative workflow includes a backend system with at least one database; at least one application configured with the database(s); and at least one user interface (UI) mechanism supporting a plurality of role-specific graphical user interfaces (GUIs) to the backend system. The backend system maintains an authoritative version of perioperative workflow information for each of a plurality of patients. One or more devices are configured with at least some of the role-specific GUIs, and operably connected to and interact with the backend system via the UI mechanism(s). Each device is configured to: receive and display perioperative workflow information from the backend system in a role-specific GUI on the device; and to send perioperative workflow information to the backend system via the role-specific GUI on the device.

Abstract: Described herein are composition and methods related to targeting the Nf1-Ras-Ets axis, that when perturbed, is identified as playing a role in initiation and maintenance in glioma. A postnatal, mosaic, autochthonous, glioma model that captures the first hours and days of gliomagenesis in more resolution than conventional genetically engineered mouse models of cancer demonstrates that disruption of the Nf1-Ras pathway in the ventricular zone at multiple signaling nodes uniformly results in rapid neural stem cell depletion, progenitor hyperproliferation, and gliogenic lineage restriction. By abolishing Ets subfamily activity, which is upregulated downstream of Ras, there is block of glioma initiation, thereby providing new therapeutic avenues for targeting glioma.

Abstract: The present invention is a novel implantable medical device comprised of a tubular double lumen, radially compressible, axially flexible and expandable, bio-absorbable “bladder”-type stent.