Patents by Inventor Moli Liu

Moli Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and biocompatible compositions to achieve sustained drug release in the eye
    Patent number: 10328033
    Abstract: A nanostructured biocompatible wafer for drug delivery to a tissue. The wafer contains a tissue-reactive mucoadhesive polymer and a mesh formed of a plurality of polymer fibers. Also provided is a method for treating an ocular surface disease, disorder, or infection using the nanostructured biocompatible wafer. Additionally, an injectable sustained-release formulation for treating an ocular disorder is disclosed. The formulation includes a drug contained within a plurality of microparticles formed of a biodegradable polymer and are coated with a tissue-reactive compound. Further provided is a method for treating an ocular disorder by injecting the microparticulate sustained release formulation.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: June 25, 2019
    Assignee: Integral BioSystems LLC
    Inventors: Shikha P. Barman, Moli Liu, Koushik Barman, Kevin L. Ward, Brendan Hackett
  • METHODS AND BIOCOMPATIBLE COMPOSITIONS TO ACHIEVE SUSTAINED DRUG RELEASE IN THE EYE
    Publication number: 20180280313
    Abstract: A nanostructured biocompatible wafer for drug delivery to a tissue. The wafer contains a tissue-reactive mucoadhesive polymer and a mesh formed of a plurality of polymer fibers. Also provided is a method for treating an ocular surface disease, disorder, or infection using the nanostructured biocompatible wafer. Additionally, an injectable sustained-release formulation for treating an ocular disorder is disclosed. The formulation includes a drug contained within a plurality of microparticles formed of a biodegradable polymer and are coated with a tissue-reactive compound. Further provided is a method for treating an ocular disorder by injecting the microparticulate sustained release formulation.
    Type: Application
    Filed: April 3, 2018
    Publication date: October 4, 2018
    Inventors: Shikha P. Barman, Moli Liu, Koushik Barman, Kevin L. Ward, Brendan Hackett
  • Methods and biocompatible compositions to achieve sustained drug release in the eye
    Patent number: 9931306
    Abstract: A nanostructured biocompatible wafer for placement in the conjunctival cul-de-sac. The wafer contains a tissue-reactive mucoadhesive polymer and a mesh formed of a plurality of hydrophobic polymer fibers. Also provided is a method for treating glaucoma, an ocular surface disorder, or an ocular surface infection using the nanostructured biocompatible wafer. Additionally, an injectable sustained-release formulation for treating an ocular disorder is disclosed. The formulation includes a drug contained within a plurality of microparticles formed of a biodegradable polymer and are coated with a tissue-reactive compound. Further provided is a method for treating an ocular disorder by injecting the microparticulate sustained release formulation.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: April 3, 2018
    Assignee: Integral Biosystems LLC
    Inventors: Shikha P. Barman, Moli Liu, Koushik Barman, Kevin L. Ward, Brendan Hackett
  • METHODS AND BIOCOMPATIBLE COMPOSITIONS TO ACHIEVE SUSTAINED DRUG RELEASE IN THE EYE
    Publication number: 20170296483
    Abstract: A nanostructured biocompatible wafer for placement in the conjunctival cul-de-sac. The wafer contains a tissue-reactive mucoadhesive polymer and a mesh formed of a plurality of hydrophobic polymer fibers. Also provided is a method for treating glaucoma, an ocular surface disorder, or an ocular surface infection using the nanostructured biocompatible wafer. Additionally, an injectable sustained-release formulation for treating an ocular disorder is disclosed. The formulation includes a drug contained within a plurality of microparticles formed of a biodegradable polymer and are coated with a tissue-reactive compound. Further provided is a method for treating an ocular disorder by injecting the microparticulate sustained release formulation.
    Type: Application
    Filed: September 8, 2015
    Publication date: October 19, 2017
    Inventors: Shikha P. Barman, Moli Liu, Koushik Barman, Kevin L. Ward, Brendan Hackett