Patents by Inventor Molly Mcadow

Molly Mcadow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS RELATED TO ANTIBODIES THAT NEUTRALIZE COAGULASE ACTIVITY DURING STAPHYLOCOCCUS AUREUS DISEASE
    Publication number: 20220227819
    Abstract: Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Coagulase (Coa). Further aspects relate to immunogenic compositions comprising at least one Staphylococcal coagulase R Domain, wherein the R Domain is 80% identical in sequence to a R Domain.
    Type: Application
    Filed: December 21, 2021
    Publication date: July 21, 2022
    Applicants: The University of Chicago, Janssen Pharmaceuticals, Inc.
    Inventors: Dominique Missiakas, Olaf Schneewind, Carla Emolo, Lena Thomer, Molly McAdow, Jeroen Geurtsen, Mark De Been
  • Compositions and methods related to antibodies that neutralize coagulase activity during disease
    Patent number: 11214600
    Abstract: Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Coagulase (Coa). Further aspects relate to immunogenic compositions comprising at least one Staphylococcal coagulase R Domain, wherein the R Domain is 80% identical in sequence to a R Domain.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: January 4, 2022
    Assignees: The University of Chicago, Janssen Pharmaceuticals, Inc.
    Inventors: Dominique Missiakas, Olaf Schneewind, Carla Emolo, Lena Thomer, Molly McAdow, Jeroen Geurtsen, Mark De Been
  • STAPHYLOCOCCAL COAGULASE ANTIGENS AND METHODS OF THEIR USE
    Publication number: 20210093706
    Abstract: The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve coagulase Domains 1-2 and variants thereof.
    Type: Application
    Filed: December 7, 2020
    Publication date: April 1, 2021
    Applicant: The University of Chicago
    Inventors: Molly McAdow, Andrea Dedent, Alice Cheng, Carla Emolo, Dominique Missiakas, Olaf Schneewind
  • Staphylococcal coagulase antigens and methods of their use
    Patent number: 10857220
    Abstract: The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve coagulase Domains 1-2 and variants thereof.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: December 8, 2020
    Assignee: The University of Chicago
    Inventors: Molly McAdow, Andrea Dedent, Alice Cheng, Carla Emolo, Dominique Missiakas, Olaf Schneewind
  • COMPOSITIONS AND METHODS RELATED TO ANTIBODIES THAT NEUTRALIZE COAGULASE ACTIVITY DURING STAPHYLOCOCCUS AUREUS DISEASE
    Publication number: 20190112342
    Abstract: Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Coagulase (Coa). Further aspects relate to immunogenic compositions comprising at least one Staphylococcal coagulase R Domain, wherein the R Domain is 80% identical in sequence to a R Domain.
    Type: Application
    Filed: February 10, 2017
    Publication date: April 18, 2019
    Inventors: Dominique Missiakas, Olaf Schneewind, Carla Emolo, Lena Thomer, Molly McAdow, Jeroen Geurtsen, Mark De Been
  • STAPHYLOCOCCAL COAGULASE ANTIGENS AND METHODS OF THEIR USE
    Publication number: 20180243394
    Abstract: The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve coagulase Domains 1-2 and variants thereof.
    Type: Application
    Filed: April 25, 2018
    Publication date: August 30, 2018
    Inventors: Molly McAdow, Andrea Dedent, Alice Cheng, Carla Emolo, Dominique Missiakas, Olaf Schneewind
  • Staphylococcal coagulase antigens and methods of their use
    Patent number: 9968668
    Abstract: The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve coagulase Domains 1-2 and variants thereof.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 15, 2018
    Assignee: The University of Chicago
    Inventors: Molly McAdow, Andrea Dedent, Alice Cheng, Carla Emolo, Dominique Missiakas, Olaf Schneewind
  • COMPOSITIONS AND METHODS RELATED TO ANTIBODIES THAT NEUTRALIZE COAGULASE ACTIVITY DURING STAPHYLOCOCCUS AUREUS DISEASE
    Publication number: 20170306004
    Abstract: Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Coagulase (Coa).
    Type: Application
    Filed: June 20, 2017
    Publication date: October 26, 2017
    Inventors: Molly McAdow, Carla Emolo, Dominique Missiakas, Olaf Schneewind
  • Compositions and methods related to antibodies that neutralize coagulase activity during disease
    Patent number: 9701738
    Abstract: Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria, in certain embodiments, the methods and compositions involve an antibody that binds Coagulase (Coa).
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 11, 2017
    Assignee: The University of Chicago
    Inventors: Molly McAdow, Carla Emolo, Dominique Missiakas, Olaf Schneewind
  • COMPOSITIONS AND METHODS RELATED TO ANTIBODIES THAT NEUTRALIZE COAGULASE ACTIVITY DURING STAPHYLOCOCCUS AUREUS DISEASE
    Publication number: 20150368322
    Abstract: Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria, in certain embodiments, the methods and compositions involve an antibody that binds Coagulase (Coa).
    Type: Application
    Filed: March 15, 2013
    Publication date: December 24, 2015
    Inventors: Molly McAdow, Carla Emolo, Dominique Missiakas, Olaf Schneewind
  • COMPOSITIONS AND METHODS RELATED TO ANTIBODIES THAT NEUTRALIZE COAGULASE ACTIVITY DURING STAPHYLOCOCCUS AUREUS DISEASE
    Publication number: 20150273040
    Abstract: The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve coagulase Domains 1-2 and variants thereof.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 1, 2015
    Inventors: Molly McAdow, Andrea Dedent, Alice Cheng, Carla Emolo, Dominique Missiakas, Olaf Schneewind
  • METHODS AND COMPOSITIONS FOR INHIBITING STAPHYLOCOCCUS AGGLUTINATION IN BLOOD
    Publication number: 20140271649
    Abstract: Certain embodiments are directed to methods of inhibiting Staphylococcal infection comprising administering effective amounts of a ClfA inhibitor and a thrombin inhibitor to a patient.
    Type: Application
    Filed: July 13, 2012
    Publication date: September 18, 2014
    Applicant: The University of Chicago
    Inventors: Olaf Schneewind, Dominique Missiakas, Molly Mcadow, Hwan Keun Kim