Abstract: Aspects of the present disclosure relate to methods and compositions useful for in vivo and/or in vitro profiling of environmental triggers (e.g., enzyme activity, pH or temperature). In some embodiments, the disclosure provides methods of in vivo enzymatic processing of exogenous molecules followed by detection of nanocatalysts as representative of the presence of active enzymes (e.g., proteases) associated with a disease, for example, cancer or infection. In some embodiments, the disclosure provides compositions and methods for production of in vivo sensors comprising nanocatalysts.

Abstract: The present invention relates to compositions, assay devices, kits and methods for detecting the presence, amount and/or activity of an analyte in a sample. In particular, the present invention relates to the detection of enzymes. The present invention also relates to methods of diagnosing diseases associated with dysregulation of enzymes, screening for modulators of enzymatic activity, candidate antimicrobial peptides and toxins.

Abstract: The present invention relates to a layered fibrous construct for use as a scaffold for repairing or replacing cartilage or cartilage-like tissue, and a process for the production thereof.

Abstract: The present invention relates to a layered fibrous construct for use as a scaffold for repairing or replacing cartilage or cartilage-like tissue, and a process for the production thereof.

Abstract: The present invention relates to compositions, assay devices, kits and methods for detecting the presence, amount and/or activity of an analyte in a sample. In particular, the present invention relates to the detection of enzymes. The present invention also relates to methods of diagnosing diseases associated with dysregulation of enzymes, screening for modulators of enzymatic activity, candidate antimicrobial peptides and toxins.

Abstract: The present invention relates to a novel carbohydrate lactone, functionalized aliphatic polyesters and copolymers formed therefrom, and processes for the preparation thereof from renewable resources.

Abstract: The present invention relates to a glass composition formulated to provide the controlled release of certain transition metal ions to regulate the cellular hypoxia pathway and the use of these hypoxia-pathway regulating glasses in medicine and in biomedical research, including in the repair, restoration or regeneration of diseased or damaged tissue.

Abstract: The present invention relates to a novel carbohydrate lactone, functionalized aliphatic polyesters and copolymers formed therefrom, and processes for the preparation thereof from renewable resources.

Abstract: The present invention relates to bioactive glass coatings. In particular, the present invention relates to bioactive glass coatings for Ti6Al4V alloys and chrome cobalt alloys, wherein the thermal expansion coefficient of the glass coating is matched to that of the alloy. Such coatings have a particular application in the field of medical prosthetics. The bioactive glass comprises (in mol %) 35-53 SiO2; 2-11 Na20; at least 2% of each of CaO, MgO and K20; 0-15 ZnO; 0-2 B202 and 0-9 P205.

Abstract: The present invention relates to glass compositions for use in formation of polycarboxylate cements and polycarboxylate cements comprising these glasses, wherein the glasses comprise SiO2 and MgO, with a molar percentage of SiO2 not exceeding 60% and a molar percentage of MgO being greater than 20%.

Abstract: The present invention relates to a bioactive glass comprising strontium and silicon dioxide, processes for the production of the bioactive glass and the use of the bioactive glass in medicine.