Publication number: 20260166047
Abstract: Disclosed herein are compounds useful for the inhibition of STAT6. The compounds have a general Formula (I) or (II) or pharmaceutically acceptable salts thereof, wherein the variables of Formula (I) and (II) are as defined herein. Also provided herein are pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, diseases/disorders related to the activity of STAT6, such as an allergic disease or an inflammatory disease, including but not limited to atopic dermatitis or bronchial asthma. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I) and (II).
Type:
Application
Filed:
December 16, 2025
Publication date:
June 18, 2026
Applicant:
AMGEN INC.
Inventors:
Liping H. PETTUS, Ana Sydelle BULGER, John Charles STELLWAGEN, Fabien EMMETIERE, Thomas FLAGSTAD, Emil GLIBSTRUP, Jeffrey JACKSON, Qingyian LIU, Quentin TERCENIO, Primali Vasundera NAVARATNE, Adriano BAUER, Slavko RAST, Andrew SMALIGO, Yujia TAO, Zhichen WU, Ningxin XU, John Gordon ALLEN, Dora TOLEDO WARSHAVIAK, Mona SHARAFI, Jason YU, Garrick Paul SMITH, Loris MORETTI, Visnja POLJAK, Adili ALAFATE, Matthew John COOK, Imelda Hot, David Huang, Jose Miguel MEDINA, Milauni Mehta UNDURTY, Cesar Nicolas PRIETO KULLMER, Hui-Ling WANG, Jingjing XIE, Nuria A. TAMAYO, Alexander James Pickrell, Minghao Wang, Wenhan Zhang