Patents by Inventor Monica E. Kleinman

Monica E. Kleinman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination therapies for treatment of laminopathies, cellular aging, and atherosclerosis
    Patent number: 11857541
    Abstract: Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin and increase progerin clearance.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: January 2, 2024
    Inventors: Leslie B. Gordon, Mark W. Kieran, Monica E. Kleinman
  • COMBINATION THERAPIES FOR TREATMENT OF LAMINOPATHIES, CELLULAR AGING, AND ATHEROSCLEROSIS
    Publication number: 20200330443
    Abstract: Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin and increase progerin clearance.
    Type: Application
    Filed: June 30, 2020
    Publication date: October 22, 2020
    Inventors: Leslie B. Gordon, Mark W. Kieran, Monica E. Kleinman
  • COMBINATION THERAPIES FOR TREATMENT OF LAMINOPATHIES, CELLULAR AGING, AND ATHEROSCLEROSIS
    Publication number: 20190046508
    Abstract: Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin and increase progerin clearance.
    Type: Application
    Filed: October 15, 2018
    Publication date: February 14, 2019
    Inventors: Leslie B. Gordon, Mark W. Kieran, Monica E. Kleinman
  • Combination therapies for treatment of laminopathies, cellular aging, and atherosclerosis
    Patent number: 10098871
    Abstract: Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin and increase progerin clearance.
    Type: Grant
    Filed: July 4, 2016
    Date of Patent: October 16, 2018
    Inventors: Leslie B. Gordon, Mark W. Kieran, Monica E. Kleinman
  • COMBINATION THERAPIES FOR TREATMENT OF LAMINOPATHIES, CELLULAR AGING, AND ATHEROSCLEROSIS
    Publication number: 20160310473
    Abstract: Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin and increase progerin clearance.
    Type: Application
    Filed: July 4, 2016
    Publication date: October 27, 2016
    Inventors: Leslie B. Gordon, Mark W. Kieran, Monica E. Kleinman
  • Combination therapies for treatment of laminopathies, cellular aging, and atherosclerosis
    Patent number: 9381203
    Abstract: Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin, and inhibit farnesyl biosynthesis, lamin A prenylation, and increase progerin clearance.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: July 5, 2016
    Inventors: Leslie B. Gordon, Mark W. Kieran, Monica E. Kleinman
  • COMBINATION THERAPIES FOR TREATMENT OF LAMINOPATHIES, CELLULAR AGING, AND ATHEROSCLEROSIS
    Publication number: 20140274964
    Abstract: Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin, and inhibit farnesyl biosynthesis, lamin A prenylation, and increase progerin clearance.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Inventors: Leslie B. Gordon, Mark W. Kieran, Monica E. Kleinman