Patents by Inventor Monica Florio

Monica Florio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterodimeric immunoglobulins
    Patent number: 11466078
    Abstract: The present application is directed to heterodimeric antibodies and methods of use.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: October 11, 2022
    Assignee: Amgen Inc.
    Inventors: Gunasekaran Kannan, Monica Florio, Zhi Liu, Wei Yan
  • Heterodimeric Immunoglobulins
    Publication number: 20190153086
    Abstract: The present application is directed to heterodimeric antibodies and methods of use.
    Type: Application
    Filed: February 5, 2019
    Publication date: May 23, 2019
    Inventors: Gunasekaran Kannan, Monica Florio, Zhi Liu, Wei Yan
  • Heterodimeric immunoglobulins
    Patent number: 10233237
    Abstract: The present application is directed to heterodimeric antibodies and methods of use.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: March 19, 2019
    Assignee: AMGEN INC.
    Inventors: Gunasekaran Kannan, Monica Florio, Zhi Liu, Wei Yan
  • Heterodimeric immunoglobulins
    Patent number: 9822173
    Abstract: The present application is directed to heterodimeric antibodies and methods of use.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: November 21, 2017
    Assignee: AMGEN INC.
    Inventors: Gunasekaran Kannan, Monica Florio, Zhi Liu, Wei Yan
  • Method of improving cell proliferation of pancreatic progenitor cells in a pancreatic cell culture
    Patent number: 9745554
    Abstract: The invention relates to the discovery that the proliferation and survival of pancreatic progenitor cells can be enhanced by contacting the cells with, (1) a caspase inhibitor sufficient to reduce apoptosis in the pancreatic endocrine cells; and, (2) a growth factor in an amount sufficient to increase the level of activated Akt in the pancreatic endocrine cells.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: August 29, 2017
    Assignee: ReNeuron, Inc.
    Inventors: Monica Florio, Aleksandar Francki, Wen-Ghih Tsang
  • Inhibitory polypeptides specific to WNT inhibitors
    Patent number: 9708375
    Abstract: The present application is directed to avimers and peptides and various combinations thereof in addition to methods of making and using them.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: July 18, 2017
    Assignee: Amgen Inc.
    Inventors: Ryan B. Case, Benjamin M. Alba, Alice Bakker, Irwin Chen, Amy N. Duguay, Monica Florio, Peng Li, Mark Leo Michaels, Mei-Mei Tsai
  • HETERODIMERIC IMMUNOGLOBULINS
    Publication number: 20160046705
    Abstract: The present application is directed to heterodimeric antibodies and methods of use.
    Type: Application
    Filed: November 21, 2013
    Publication date: February 18, 2016
    Inventors: Gunasekaran KANNAN, Monica FLORIO, Zhi LIU, Wei YAN
  • Inhibitory Polypeptides Specific to WNT Inhibitors
    Publication number: 20160024158
    Abstract: The present application is directed to avimers and peptides and various combinations thereof in addition to methods of making and using them.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Inventors: Ryan B. CASE, Benjamin M. ALBA, Alice BAKKER, Irwin CHEN, Amy N. DUGUAY, Monica FLORIO, Peng LI, Mark Leo MICHAELS, Mei-mei TSAI
  • Bispecific binding agents
    Patent number: 9133272
    Abstract: The invention relates to bispecific anti-sclerostin/anti-DKK1 binding agents and combinations of anti-sclerostin and anti-DKK1 binding agents, and related methods of treatment.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: September 15, 2015
    Assignee: AMGEN INC.
    Inventors: Monica Florio, Taruna Arora, Christopher J. R. Paszty, William G. Richards
  • HETERODIMERIC IMMUNOGLOBULINS
    Publication number: 20140154254
    Abstract: The present application is directed to heterodimeric antibodies and methods of use.
    Type: Application
    Filed: November 21, 2013
    Publication date: June 5, 2014
    Applicant: AMGEN INC.
    Inventors: Gunasekaran Kannan, Monica Florio, Zhi Liu, Wei Yan
  • BISPECIFIC BINDING AGENTS
    Publication number: 20130164293
    Abstract: The invention relates to bispecific anti-sclerostin/anti-DKK1 binding agents and combinations of anti-sclerostin and anti-DKK1 binding agents, and related methods of treatment.
    Type: Application
    Filed: February 29, 2012
    Publication date: June 27, 2013
    Inventors: Monica Florio, Taruna Arora, Christopher J. R. Paszty, William G. Richards
  • METHOD OF IMPROVING CELL PROLIFERATION OF PANCREATIC PROGENITOR CELLS IN A PANCREATIC CELL CULTURE
    Publication number: 20100311166
    Abstract: The invention relates to the discovery that the proliferation and survival of pancreatic progenitor cells can be enhanced by contacting the cells with, (1) a caspase inhibitor sufficient to reduce apoptosis in the pancreatic endocrine cells; and, (2) a growth factor in an amount sufficient to increase the level of activated Akt in the pancreatic endocrine cells.
    Type: Application
    Filed: January 18, 2007
    Publication date: December 9, 2010
    Applicant: ReNeuron, Inc.
    Inventors: Monica Florio, Aleksandar Francki, Wen-Ghih Tsang
  • Apoptotic peptides
    Patent number: 6127178
    Abstract: Apoptosis-promoting recombinant Id polypeptides comprise an Id N-terminus domainpeptides comprise an Id N-terminus domain peptide comprising an effective portion of the N-terminal domain of a natural Id protein. The polypeptides may be produced recombinantly from transformed host cells from the subject recombinant Id polypeptide encoding nucleic acids. The invention provides methods of making and using the subject compositions and mimic thereof to modulate cellular physiology, and especially promote apoptosis and in the biopharmaceutical industry.
    Type: Grant
    Filed: March 20, 1998
    Date of Patent: October 3, 2000
    Assignee: The Regents of the University of California
    Inventors: Mark A. Israel, Monica Florio
  • 17-hydroxyiminomethyl-5-.beta., 14 .beta.-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same
    Patent number: 5444055
    Abstract: 17-hydroxyiminomethyl-14.beta.-hydroxy-5.beta.
    Type: Grant
    Filed: August 16, 1993
    Date of Patent: August 22, 1995
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Alberto Cerri, Luigi Bernardi, Giuseppe Bianchi, Monica Florio, Elena Folpini, Piero Melloni