Patents by Inventor Monica Jonsson
Monica Jonsson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8017152Abstract: Process for producing parenterally administrable cores. The cores are intermediates suitable for manufacturing sustained release preparations. Microcapsules incorporating a core and a shell and pharmaceutical compositions incorporating such cores and microcapsules are also provided.Type: GrantFiled: May 24, 2006Date of Patent: September 13, 2011Assignee: Stratosphere Pharma ABInventors: Nils Ove Gustafsson, Monica Jonsson, Timo Laakso
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Publication number: 20070142325Abstract: Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, subjecting the starch to a molecular weight reduction by acid hydrolysis, and optionally removing residual water-soluble proteins. Purified starch and microparticles based on such starch.Type: ApplicationFiled: February 2, 2007Publication date: June 21, 2007Inventors: Nils Gustavsson, Monica Jonsson, Per Berden, Timo Laakso, Mats Reslow
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Publication number: 20070122484Abstract: A process for producing microparticles containing biologically active substance, in which process an aqueous solution of the said substance is prepared, this solution is mixed with an aqueous solution of PEG such that the substance is concentrated and/or solidified, the substance is optionally washed, the substance is mixed with an aqueous starch solution, the composition obtained is mixed, after the admixture of the starch solution, with a polymer solution, thereby forming an emulsion of starch droplets in the polymer solution, the starch droplets are solidified into microparticles, the microparticles are dried and a release-controlling shell is optionally applied to these. Novel microparticles which are obtainable by means of this process.Type: ApplicationFiled: December 22, 2006Publication date: May 31, 2007Inventors: Monica Jonsson, Timo Laakso, Mats Reslow
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Publication number: 20060269606Abstract: Process for producing parenterally administrable cores. The cores are intermediates suitable for manufacturing sustained release preparations. Microcapsules incorporating a core and a shell and pharmaceutical compositions incorporating such cores and microcapsules are also provided.Type: ApplicationFiled: May 24, 2006Publication date: November 30, 2006Inventors: Nils Gustafsson, Monica Jonsson, Timo Laakso
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Patent number: 7119195Abstract: Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, dissolving the starch in aqueous medium, molecular weight reduction by shearing, and optionally removal of residual water-soluble proteins, preferably by anion exchange chromatography. Purified starch and microparticles based on such starch.Type: GrantFiled: July 28, 2003Date of Patent: October 10, 2006Assignee: Jagotec AGInventors: Nils Ove Gustavsson, Monica Jönsson, Per Berdén, Timo Laakso
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Patent number: 7105181Abstract: A process for producing parenterally administrable microparticles, in which an at least 20% by weight aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are made to gel, and the gelled starch particles are dried. A release-controlling shell is optionally also applied to the particles. Microparticles which essentially consist of said starch, have an amino acid content of less than 50 ?g and have no covalent chemical cross-linking.Type: GrantFiled: November 10, 2003Date of Patent: September 12, 2006Assignee: Jagotec, AGInventors: Nils Ove Gustavsson, Monica Jönsson, Timo Laakso, Mats Reslow
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Patent number: 7033609Abstract: A parenterally administrable, biodegradable microparticle preparation containing a biologically active substance which, during the first 24 hours after injection, exhibits a release of the active substance that is less than 25% of the total release, determined from a concentration-time curve in the form of the ratio between the area under the curve during the said first 24 hours and the total area under the curve in questionType: GrantFiled: January 10, 2002Date of Patent: April 25, 2006Assignee: Jagotec AGInventors: Nils Ove Gustavsson, Monica Jönsson, Timo Laakso, Mats Reslow, Sören Björn, Jörn Drustrup
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Patent number: 6936278Abstract: A process for producing microparticles, in which an aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are made to gel, the gelled starch particles are dried, and a release-controlling shell is optionally applied to the particles, wherein at least one buffer substance having the ability of keeping the pH of the produced microparticles above 3 if exposing the microparticles to an aqueous evironment is added at any stage during the process. Microparticles which essentially consist of said starch, have an amino acid content of less than 50 ?g and have no covalent chemical cross-linking and which have the aktivity of keeping the pH above 3 if exposed to a aqueous environment.Type: GrantFiled: June 6, 2002Date of Patent: August 30, 2005Assignee: Jagotec AGInventors: Mats Reslow, Monica Jönsson, Karin Larsson, Timo Laakso
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Publication number: 20040115281Abstract: A process for producing parenterally administrable microparticles, in which an at least 20% by weight aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are made to gel, and the gelled starch particles are dried. A release-controlling shell is optionally also applied to the particles.Type: ApplicationFiled: November 10, 2003Publication date: June 17, 2004Inventors: Nils Ove Gustavsson, Monica Jonsson, Timo Laakso, Mats Reslow
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Patent number: 6706288Abstract: A process for producing parenterally administrable microparticles, in which an at least 20% by weight aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are made to gel, and the gelled starch particles are dried. A release-controlling shell is optionally also applied to the particles. Microparticles which essentially consist of said starch, have an amino acid content of less than 50 &mgr;g and have no covalent chemical cross-linking.Type: GrantFiled: October 5, 2001Date of Patent: March 16, 2004Assignee: Jagotec AGInventors: Nils Ove Gustavsson, Monica Jönsson, Timo Laakso, Mats Reslow
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Patent number: 6692770Abstract: A process for producing parenterally administrable microparticles, in which an at least 20% by weight aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are med to gel, and the gelled starch particles are dried. A release-controlling shell is optionally also applied to the particles. Microparticles which essentially consist of said starch, have an amino acid content of less than 50 &mgr;g and have no covalent chemical cross-linking.Type: GrantFiled: June 16, 2003Date of Patent: February 17, 2004Assignee: Jagotec AGInventors: Nils Ove Gustavsson, Monica Jönsson, Timo Laakso, Mats Reslow
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Patent number: 6689389Abstract: Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, dissolving the starch in aqueous medium, molecular weight reduction by shearing, and optionally removal of residual water-soluble proteins, preferably by anion exchange chromatography. Purified starch and microparticles based on such starch.Type: GrantFiled: October 5, 2001Date of Patent: February 10, 2004Assignee: Jagotec AGInventors: Nils Ove Gustavsson, Monica Jönsson, Per Berdén, Timo Laakso, Mats Reslow
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Publication number: 20040019014Abstract: Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, dissolving the starch in aqueous medium, molecular weight reduction by shearing, and optionally removal of residual water-soluble proteins, preferably by anion exchange chromatography.Type: ApplicationFiled: July 28, 2003Publication date: January 29, 2004Applicant: JAGOTEC AG.Inventors: Nils Ove Gustavsson, Monica Jonsson, Per Berden, Timo Laakso
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Publication number: 20030211167Abstract: A process for producing parenterally administrable microparticles, in which an at least 20% by weight aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are made to gel, and the gelled starch particles are dried. A release-controlling shell is optionally also applied to the particles.Type: ApplicationFiled: June 16, 2003Publication date: November 13, 2003Applicant: Jagotec AGInventors: Nils Ove Gustavsson, Monica Jonsson, Timo Laakso, Mats Reslow
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Publication number: 20030206961Abstract: Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, subjecting the starch to a molecular weight reduction by acid hydrolysis, and optionally removing residual water-soluble proteins.Type: ApplicationFiled: June 16, 2003Publication date: November 6, 2003Applicant: Jagotec AGInventors: Nils Ove Gustavsson, Monica Jonsson, Per Berdeh, Timo Laakso, Mats Reslow
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Publication number: 20030180371Abstract: A process for producing microparticles, in which an aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are made to gel, the gelled starch particles are dried, and a release-controlling shell is optionally applied to the particles, wherein at least one buffer substance having the ability of keeping the pH of the produced microparticles above 3 if exposing the microparticles to an aqueous evironment is added at any stage during the process.Type: ApplicationFiled: June 6, 2002Publication date: September 25, 2003Inventors: Mats Reslow, Monica Jonsson, Karin Larsson, Timo Laakso
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Patent number: 6616949Abstract: A process for producing microparticles containing biologically active substance, in which process an aqueous solution of the said substance is prepared, this solution is mixed with an aqueous solution of PEG such that the substance is concentrated and/or solidified, the substance is optionally washed, the substance is mixed with an organic polymer solution, the composition obtained is mixed, after the admixture of said polymer solution, with an aqueous polymer solution, thereby forming an emulsion of droplets of first mentioned polymer as the internal phase, said droplets are solidified into microparticles, the microparticles are dried and a release-controlling shell is optionally applied to these.Type: GrantFiled: October 5, 2001Date of Patent: September 9, 2003Assignee: Jagotec AGInventors: Monica Jönsson, Timo Laakso, Mats Reslow
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Patent number: 6616948Abstract: Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, subjecting the starch to a molecular weight reduction by acid hydrolysis, and optionally removing residual water-soluble proteins. Purified starch and microparticles based on such starch.Type: GrantFiled: October 5, 2001Date of Patent: September 9, 2003Assignee: Jagotec AGInventors: Nils Ove Gustavsson, Monica Jönsson, Per Berdén, Timo Laakso, Mats Reslow
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Publication number: 20020102311Abstract: A parenterally administrable, biodegradable microparticle preparation containing a biologically active substance which, during the first 24 hours after injection, exhibits a release of the active substance that is less than 25% of the total release, determined from a concentration-time curve in the form of the ratio between the area under the curve during the said first 24 hours and the total area under the curve in questionType: ApplicationFiled: January 10, 2002Publication date: August 1, 2002Inventors: Nils Ove Gustavsson, Monica Jonsson, Timo Laakso, Mats Reslow, Soren Bjorn, Jorn Drustrup
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Publication number: 20020098203Abstract: A vaccine composition which comprises an immnunologically active substance embedded in microparticles essentially consisting of starch having an amylopectin content exceeding 85% by weight, of which at least 80% by weight has an average molecular weight within the range of 10-10000 kDa, and without any covalent chemical cross-linking between the starch molecules.Type: ApplicationFiled: January 10, 2002Publication date: July 25, 2002Inventors: Nils Ove Gustavsson, Monica Jonsson, Timo Laakso, Mats Reslow, Karin Larsson