Abstract: A micro-droplet plate including at least one fixed element which is a rigid flat support which has an upper face and a lower face, having, on said upper face, wells connected together by microchannels, said wells being delimited by a hydrophobic rim and crossed by a hole, where said wells and said microchannels define at least one microfluidic circuit; and moving elements, received in said wells through said holes, which are cylinders having an upper base and a lower base. The moving elements move, even independently of each other, along their vertical axis, and the upper base of said moving elements includes a hydrophilic surface with relief items.

Abstract: It is an object of the present invention a method to introduce compounds inside red blood cells comprising: —providing red blood cells from a subject; —providing one or more compounds to be encapsulated in said red blood cells; —providing a loading device comprising a microporous matrix; —feeding said loading device with a suspension comprising said red blood cells and said one or more compounds; —collecting the red blood cells exiting from said loading device, which are encapsulated red blood cells; characterized in that: —said red blood cells and said one or more compound are in suspension at a pH of between 6.8 and 7.8, preferably of between 7.35 and 7.

Abstract: The present invention relates to a method and microfluidic device for introducing compounds into red blood cells.