Abstract: An occlusion device (210) is provided for occluding a left atrial appendage (LAA), including a compliant balloon (230) defining a fluid-tight balloon chamber (232), and an actuating shaft (234), which is disposed at least partially within the balloon chamber (232) for setting a distance between distal and proximal end portions (236, 238) of the balloon (230). A proximal LAA-orifice cover (70) includes a frame (72) and a covering (74) fixed to the frame (72). An orifice-support stent (290) is fixed to and extends distally from the proximal LAA-orifice cover (70), and is generally cylindrical when in a radially-expanded state. Other embodiments are also described.

Abstract: An occlusion device (210) is provided for occluding a left atrial appendage (LAA), including a compliant balloon (230) defining a fluid-tight balloon chamber (232), and an actuating shaft (234), which is disposed at least partially within the balloon chamber (232) for setting a distance between distal and proximal end portions (236, 238) of the balloon (230). A proximal LAA-orifice cover (70) includes a frame (72) and a covering (74) fixed to the frame (72). An orifice-support stent (290) is fixed to and extends distally from the proximal LAA-orifice cover (70), and is generally cylindrical when in a radially-expanded state. Other embodiments are also described.

Abstract: A coaptation-assist device (20, 120A, 120B, 120C, 320A, 320B, 420, 720) is provided for treating a native atrioventricular valve, including a loop-shaped ventricular anchor (30, 130, 330, 430, 730) which includes an anchor-loop wire loop (50, 150, 350, 450, 750), which defines at least a portion of a border of the loop-shaped ventricular anchor, and is configured to be positioned in a ventricle, extending between a ventricular apical area and a subannular surface of a target native leaflet, and to remain anchored in position against surrounding anatomy, including the subannular surface, a ventricular wall, and the ventricular apical area. A neo-leaflet (32, 132A, 132B, 132C, 332A, 332B, 332A, 332B, 432, 732) is supported by the loop-shaped ventricular anchor and is configured to at least partially replace function of the target native leaflet by providing a surface of coaptation (34, 434, 734) for one or more opposing native leaflets that oppose the target native leaflet. Other embodiments are also described.